URE

UREA

Created:	1999-07-08
Last modified:	2024-09-27

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88 entries where URE is found as a standalone ligand1 entries where URE is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	8
Chiral Atom Count	0
Bond Count	7
Aromatic Bond Count	0

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Chemical Component Summary
Name	UREA
Systematic Name (OpenEye OEToolkits)	urea
Formula	C H₄ N₂ O
Molecular Weight	60.055
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(N)N
SMILES	CACTVS	3.341	NC(N)=O
SMILES	OpenEye OEToolkits	1.5.0	C(=O)(N)N
Canonical SMILES	CACTVS	3.341	NC(N)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(=O)(N)N
InChI	InChI	1.03	InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
InChIKey	InChI	1.03	XSQUKJJJFZCRTK-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB03904
Name	Urea
Groups	investigational approved
Description	A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Synonyms	Urea Carbonyldiamide Urée Harnstoff Carbamide Karbamid
Brand Names	Calmurid Crm Ciclopirox 3% / Itraconazole 5% / Urea 20% Rea Lo 40 Urea 50% Emulsion Velvelan Crm 10% Urederm Cream 10% Latrix Uramaxin Clear 40 Plus HA Urevaz Urea 41% Thomas Formula No 28 YouGreen F Ure-K Not Applicable Urea Gel 40% Kerafoam 42 RE Urea Clear 40 Urea Nail X Viate Dermasorb XM Complete Kit Urea Cream 40 Percent Uramaxin TS Urea 50 Urealac Uremol HC Umecta Mousse Urea Bare 40 Plus SA Keralac Uremol 20% cream Carb-O-Philic Lactic Acid 10% / Urea 40% Umecta Urea Bare 40 HA Keratol 45 Nail Urea 40 CEM-Urea Coppermagic Pain Relief Balm Miracle FootCream Lemon Remeven Clear 50 Nail Gel Dr. Scholl's Cracked Heel Relief Cream Thomas Formula No 47 Noxipak Velvelan Lot 10% Urea 47% Cream Kerafoam Amino-cerv Carbamex 330mgms Flexitol Heel Balm Kerol AD Gordons Urea 40 Pedipak Psoricare Crm 3% Umecta PD Urea X-Viate Dermetazole U40 Hydro 35 Keralac Nailstik Heel Balm Urea Cream 41% MeTopic Aluvea Clear 40 Plus SA Urea Urea 40 Plus HA Gehwol med Lipidro Urea 40% Uremol 10 Crm 10% Cream Bare 40 Miracle FootCream Lavender Ure-39 Keratol 45 cream Uramaxin Pads Uremol 10 Lotion 10% Revitaderm 40 Kerasal Topical Solution Urea 47 Urea Hydrating Topical Urea 41 Percent Podiatrole Re Urea Carmol 40 Gehwol FUSSKRAFT Callus Softener Rea Lo 39 Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% Uramaxin GT Urea 39.5% Gehwol med Callus Keratol 40 Urea 20 Urea 40 Percent W.skin Cica Foot Peeling Bare 40 Plus HA Ti-U-lac Lotion Calmurid HC Crm Thomas Formula No 17 Ti-U-lac HC Lotion Urea 40 Plus SA Bare 20 Urea 39.5% with 2% Salicylic Acid Miin Foot Bare 40 SA Rynoderm Urea 39% Cream Urea Cream 40% Utopic Hydrophil Ont Xurea Urea 40 Nail Gel Uremol Pro-39 Urea
Indication	Urea is used topically for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns and calluses, as well as damaged, devitalized and ingrown nails.[L41484]
Categories	Amides Blood and Blood Forming Organs Blood Substitutes and Perfusion Solutions Carbamide products Dermatologicals Diuretics, Osmotic Emollients and Protectives i.v. Solutions Keratolytic Agents Solutions Producing Osmotic Diuresis
ATC-Code	D02AE01 B05BC02 D02AE51
CAS number	57-13-6

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Dihydrofolate reductase	VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAV...	unknown	activator
Arginase-1	MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDY...	unknown
Carbonic anhydrase 2	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...	unknown
Catenin beta-1	MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKG...	unknown
Sulfoxide reductase catalytic subunit YedY	MKKNQFLKESDVTAESVFFMKRRQVLKALGISAAALSLPHAAHADLLSWF...	unknown
Urea transporter 2	MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEK...	unknown	substrate
Urea transporter 1	MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLK...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL985
PubChem	1176
ChEMBL	CHEMBL985
ChEBI	CHEBI:48376, CHEBI:16199
CCDC/CSD	ACUFUR01, ACUYAY, BARBUR01, ACUYEC, AZUQAP, BARBUR02, BARBUR06, BARBUR03, BARBUR04, BARBUR05, BARBUR, AWISOO, ACUFUR, BAFTEH, BAQZOI, AMIMAK, AMILUD01, AMILUD, AMILEN, BAFSOQ, AWISUU, BAFWIO, AMILEN01, ARAMEO, AQUMIL01, AQUMIL
COD	2016711, 2016712, 1008775, 1008776, 1008786, 1008787, 2019369, 2311086, 1544223, 1544224, 1544225, 1544226, 2022025, 2003112