ZAR

6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE

Created:	2002-08-30
Last modified:	2011-06-04

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2 entries where ZAR is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	29
Chiral Atom Count	0
Bond Count	30
Aromatic Bond Count	13

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Chemical Component Summary
Name	6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE
Systematic Name (OpenEye OEToolkits)	6-[4-(difluoromethoxy)-3-methoxy-phenyl]-2H-pyridazin-3-one
Formula	C₁₂ H₁₀ F₂ N₂ O₃
Molecular Weight	268.216
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C1C=CC(=NN1)c2cc(OC)c(OC(F)F)cc2
SMILES	CACTVS	3.341	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
SMILES	OpenEye OEToolkits	1.5.0	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
Canonical SMILES	CACTVS	3.341	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
Canonical SMILES	OpenEye OEToolkits	1.5.0	COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
InChI	InChI	1.03	InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChIKey	InChI	1.03	HJMQDJPMQIHLPB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB02918
Name	Zardaverine
Groups	experimental
Synonyms	6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone Zardaverine zardaverina
Categories	Anti-Asthmatic Agents Autonomic Agents Bronchodilator Agents Enzyme Inhibitors Peripheral Nervous System Agents Phosphodiesterase Inhibitors Respiratory System Agents
CAS number	101975-10-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRL...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682