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234,136 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Huai, Q."

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

	Homo sapiens (12)
	Escherichia coli (2)
	Lentzea aerocolonigenes (2)
	Solanum lycopersicum (2)
	Mus musculus (1)
	Tolypocladium inflatum (1)

Taxonomy

	Eukaryota (14)
	Bacteria (4)

Experimental Method

X-RAY DIFFRACTION (18)

Polymer Entity Type

	Protein (18)
	DNA (1)

Refinement Resolution (Å)

	1.5 - 2.0 (3)
	2.0 - 2.5 (10)
	2.5 - 3.0 (5)

Release Date

	2000 - 2004 (10)
	2005 - 2009 (8)

Enzyme Classification Name

	Hydrolases (14)
	Lyases (2)
	Isomerases (1)

Symmetry Type

	Cyclic (9)
	Asymmetric (5)
	Dihedral (6)

SCOP Classification

	All alpha proteins (10)
	Alpha and beta proteins (a/b) (5)
	All beta proteins (2)
	Small proteins (1)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 18 of 18 Structures

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1EV7 \| pdb_00001ev7	Download File View File

CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI

Huai, Q., Colandene, J.D., Chen, Y., Luo, F., Zhao, Y.

(2000) EMBO J 19: 3110-3118

Released	2000-10-19
Method	X-RAY DIFFRACTION 2.38 Å
Organisms	Lentzea aerocolonigenes
Macromolecule	TYPE IIE RESTRICTION ENDONUCLEASE NAEI (protein)

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1IAW \| pdb_00001iaw	Download File View File

CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA

Huai, Q., Colandene, J.D., Topal, M.D., Ke, H.

(2001) Nat Struct Biol 8: 665-669

Released	2001-08-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Lentzea aerocolonigenes
Macromolecule	TYPE II RESTRICTION ENZYME NAEI (protein) 5'-D(TPGPCPCPAPCPGPCPCPGPGPCPGPTPGPGP*C)-3' (nucleic acid)

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1IAX \| pdb_00001iax	Download File View File

CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP

Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H.

(2001) J Biological Chem 276: 38210-38216

Released	2001-04-04
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Solanum lycopersicum
Macromolecule	1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2 (protein)
Unique Ligands	PLP, SO4

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1IAY \| pdb_00001iay	Download File View File

CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG

Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H.

(2001) J Biological Chem 276: 38210-38216

Released	2001-04-04
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Solanum lycopersicum
Macromolecule	1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2 (protein)
Unique Ligands	AVG, PLP

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1M63 \| pdb_00001m63	Download File View File

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.

(2002) Proc Natl Acad Sci U S A 99: 12037

Released	2002-09-25
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Tolypocladium inflatum
Macromolecule	CALCINEURIN B SUBUNIT ISOFORM 1 (protein) CYCLOSPORIN A (protein) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (protein) SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM (protein)
Unique Ligands	CA, FE, ZN

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1OYN \| pdb_00001oyn	Download File View File

Crystal structure of PDE4D2 in complex with (R,S)-rolipram

Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.

(2003) Structure 11: 865-873

Released	2003-07-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific phosphodiesterase PDE4D2 (protein)
Unique Ligands	ROL, ZN

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1PTW \| pdb_00001ptw	Download File View File

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis

Huai, Q., Colicelli, J., Ke, H.

(2003) Biochemistry 42: 13220-13226

Released	2003-11-11
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific phosphodiesterase PDE4D2 (protein)
Unique Ligands	AMP, ZN

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1Q2U \| pdb_00001q2u	Download File View File

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

Huai, Q., Sun, Y., Wang, H., Chin, L.S., Li, L., Robinson, H., Ke, H.

(2003) FEBS Lett 549: 171-175

Released	2003-10-07
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	RNA-binding protein regulatory subunit (protein)

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1Q9M \| pdb_00001q9m	Download File View File

Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.

(2003) Structure 11: 865-873

Released	2003-09-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific phosphodiesterase PDE4D2 (protein)
Unique Ligands	ROL, ZN

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1RKP \| pdb_00001rkp	Download File View File

Crystal structure of PDE5A1-IBMX

Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.

(2004) J Biological Chem 279: 13095-13101

Released	2004-03-30
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	cGMP-specific 3',5'-cyclic phosphodiesterase (protein)
Unique Ligands	IBM, MG, ZN

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1Y4S \| pdb_00001y4s	Download File View File

Conformation rearrangement of heat shock protein 90 upon ADP binding

Huai, Q., Wang, H., Liu, Y., Kim, H., Toft, D., Ke, H.

(2005) Structure 13: 579-590

Released	2005-04-19
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli
Macromolecule	Chaperone protein htpG (protein)
Unique Ligands	ADP, MG

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1Y4U \| pdb_00001y4u	Download File View File

Conformation rearrangement of heat shock protein 90 upon ADP binding

Huai, Q., Wang, H., Liu, Y., Kim, H., Toft, D., Ke, H.

(2005) Structure 13: 579-590

Released	2005-04-19
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Escherichia coli
Macromolecule	Chaperone protein htpG (protein)

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1ZKN \| pdb_00001zkn	Download File View File

Structure of PDE4D2-IBMX

Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.

(2004) J Biological Chem 279: 13095-13101

Released	2005-05-17
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (protein)
Unique Ligands	IBM, MG, ZN

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2FD6 \| pdb_00002fd6	Download File View File

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

Huang, M., Huai, Q., Li, Y.

(2006) Science 311: 656-659

Released	2006-02-21
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	H chain of Fab of ATN-615 anti-uPAR antibody (protein) L chain of Fab of ATN-615 anti-uPAR antibody (protein) Urokinase plasminogen activator surface receptor (protein) Urokinase-type plasminogen activator (protein)
Unique Ligands	EDO, ETX, NDG, PG4, PGE, SO4
Unique branched monosaccharides	FUC, NAG

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2FM0 \| pdb_00002fm0	Download File View File

Crystal structure of PDE4D in complex with L-869298

Huai, Q., Sun, Y., Wang, H., Macdonald, D., Aspiotis, R., Robinson, H., Huang, Z., Ke, H.

(2006) J Med Chem 49: 1867-1873

Released	2006-03-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (protein)
Unique Ligands	M98, MG, ZN

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2FM5 \| pdb_00002fm5	Download File View File

Crystal structure of PDE4D2 in complex with inhibitor L-869299

Huai, Q., Sun, Y., Wang, H., Macdonald, D., Aspiotis, R., Robinson, H., Huang, Z., Ke, H.

(2006) J Med Chem 49: 1867-1873

Released	2006-03-28
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (protein)
Unique Ligands	M99, MG, ZN

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2H40 \| pdb_00002h40	Download File View File

Crystal structure of the catalytic domain of unliganded PDE5

Wang, H., Liu, Y., Huai, Q., Cai, J., Zoraghi, R., Francis, S.H., Corbin, J.D., Robinson, H., Xin, Z., Lin, G., Ke, H.

(2006) J Biological Chem 281: 21469-21479

Released	2006-06-06
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	cGMP-specific 3',5'-cyclic phosphodiesterase (protein)
Unique Ligands	MG, ZN

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2HD1 \| pdb_00002hd1	Download File View File

Crystal structure of PDE9 in complex with IBMX

Huai, Q., Wang, H., Zhang, W., Colman, R.W., Robinson, H., Ke, H.

(2004) Proc Natl Acad Sci U S A 101: 9624-9629

Released	2006-06-27
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Phosphodiesterase 9A (protein)
Unique Ligands	IBM, MG, ZN

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1EV7 | pdb_00001ev7

CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI

1IAW | pdb_00001iaw

CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA

1IAX | pdb_00001iax

CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP

1IAY | pdb_00001iay

CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG

1M63 | pdb_00001m63

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

1OYN | pdb_00001oyn

Crystal structure of PDE4D2 in complex with (R,S)-rolipram

1PTW | pdb_00001ptw

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis

1Q2U | pdb_00001q2u

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

1Q9M | pdb_00001q9m

Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity

1RKP | pdb_00001rkp

Crystal structure of PDE5A1-IBMX

1Y4S | pdb_00001y4s

Conformation rearrangement of heat shock protein 90 upon ADP binding

1Y4U | pdb_00001y4u

Conformation rearrangement of heat shock protein 90 upon ADP binding

1ZKN | pdb_00001zkn

Structure of PDE4D2-IBMX

2FD6 | pdb_00002fd6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

2FM0 | pdb_00002fm0

Crystal structure of PDE4D in complex with L-869298

2FM5 | pdb_00002fm5

Crystal structure of PDE4D2 in complex with inhibitor L-869299

2H40 | pdb_00002h40

Crystal structure of the catalytic domain of unliganded PDE5

2HD1 | pdb_00002hd1

Crystal structure of PDE9 in complex with IBMX

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1EV7 | pdb_00001ev7

1IAW | pdb_00001iaw

1IAX | pdb_00001iax

1IAY | pdb_00001iay

1M63 | pdb_00001m63

1OYN | pdb_00001oyn

1PTW | pdb_00001ptw

1Q2U | pdb_00001q2u

1Q9M | pdb_00001q9m

1RKP | pdb_00001rkp

1Y4S | pdb_00001y4s

1Y4U | pdb_00001y4u

1ZKN | pdb_00001zkn

2FD6 | pdb_00002fd6

2FM0 | pdb_00002fm0

2FM5 | pdb_00002fm5

2H40 | pdb_00002h40

2HD1 | pdb_00002hd1