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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Structure Author = "Tulinsky, A."

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Search Summary

This query matches 81 Structures.

Refinements

Structure Determination Methodology

experimental (81)

Scientific Name of Source Organism

	Homo sapiens (69)
	Hirudo medicinalis (28)
	Bos taurus (10)
	Ancylostoma caninum (2)
	Hirudinaria manillensis (2)
	Pseudomonas putida (2)
	Aspergillus oryzae (1)
	Bothrops asper (1)
	Microcystis aeruginosa (1)
	Ornithodoros moubata (1)

More...

Taxonomy

	Eukaryota (79)
	Eukaryota (eukaryotes) (11)
	Bacteria (4)
	other sequences (1)

Experimental Method

X-RAY DIFFRACTION (81)

Polymer Entity Type

	Protein (81)
	DNA (3)

Refinement Resolution (Å)

	1.5 - 2.0 (12)
	2.0 - 2.5 (49)
	2.5 - 3.0 (11)
	3.0 - 3.5 (7)
	3.5 - 4.0 (2)

Release Date

	1975 - 1979 (1)
	1985 - 1989 (2)
	1990 - 1994 (34)
	1995 - 1999 (30)
	2000 - 2004 (11)
	2005 - 2009 (3)

Enzyme Classification Name

	Hydrolases (78)
	Lyases (3)

Symmetry Type

	Asymmetric (76)
	Cyclic (8)

SCOP Classification

	All beta proteins (58)
	Small proteins (26)
	Alpha and beta proteins (a+b) (1)
	All alpha proteins (1)
	Alpha and beta proteins (a/b) (1)
	Artifacts (1)
	Low resolution protein structures (1)

AllSelected

1 to 25 of 81 Structures

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1A2C \| pdb_00001a2c	Download File View File

Structure of thrombin inhibited by AERUGINOSIN298-A from a BLUE-GREEN ALGA

Rios-Steiner, J.L., Murakami, M., Tulinsky, A.

(1998) J Am Chem Soc 120: 597

Released	1998-07-01
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens Microcystis aeruginosa
Macromolecule	Aeruginosin 298-A (protein) Hirudin variant-2 (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	NA

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1A46 \| pdb_00001a46	Download File View File

THROMBIN COMPLEXED WITH HIRUGEN AND A BETA-STRAND MIMETIC INHIBITOR

St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.12 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00K, NA

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1A4W \| pdb_00001a4w	Download File View File

CRYSTAL STRUCTURES OF THROMBIN WITH THIAZOLE-CONTAINING INHIBITORS: PROBES OF THE S1' BINDING SITE

Matthews, J.H., Krishnan, R., Costanzo, M.J., Maryanoff, B.E., Tulinsky, A.

(1996) Biophys J 71: 2830-2839

Released	1998-04-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	NA, QWE

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1A5G \| pdb_00001a5g	Download File View File

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

St Charles, R., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00L, NA

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1A61 \| pdb_00001a61	Download File View File

THROMBIN COMPLEXED WITH A BETA-MIMETIC THIAZOLE-CONTAINING INHIBITOR

St Charles, R., Matthews, J.H., Zhang, E., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-06-17
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRUGEN (protein)
Unique Ligands	00N, NA

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1ABI \| pdb_00001abi	Download File View File

STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS

Qiu, X., Tulinsky, A.

(1992) Biochemistry 31: 11689-11697

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein) HIRULOG 3 (protein)

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1ABJ \| pdb_00001abj	Download File View File

STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS

Qiu, X., Tulinsky, A.

(1992) Biochemistry 31: 11689-11697

Released	1994-01-31
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	ALPHA-THROMBIN (LARGE SUBUNIT) (protein) ALPHA-THROMBIN (SMALL SUBUNIT) (protein)
Unique Ligands	0G6

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1AY6 \| pdb_00001ay6	Download File View File

THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF

Ganesh, V., Maryanoff, B.E., Tulinsky, A.

(1996) Bioorg Med Chem Lett 6: 2947-2952

Released	1998-03-18
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN HEAVY CHAIN (protein) THROMBIN LIGHT CHAIN (protein)
Unique Ligands	1ZV

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1B5G \| pdb_00001b5g	Download File View File

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

St Charles, R., Tulinsky, A., Kahn, M.

(1999) J Med Chem 42: 1376-1383

Released	1998-05-27
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	ALPHA-THROMBIN (protein) HIRUGEN (protein)
Unique Ligands	0ZE, NA

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1BA8 \| pdb_00001ba8	Download File View File

THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

(1998) Biochemistry 37: 12094-12103

Released	1999-04-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	0IT, NAG

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1BB0 \| pdb_00001bb0	Download File View File

THROMBIN INHIBITORS WITH RIGID TRIPEPTIDYL ALDEHYDES

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

(1998) Biochemistry 37: 12094-12103

Released	1999-04-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	0IV, NA

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1C4U \| pdb_00001c4u	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	PROTEIN (HIRUGEN) (protein) thrombin (protein)
Unique Ligands	IH1, NA

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1C4V \| pdb_00001c4v	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH2, NA

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1C4Y \| pdb_00001c4y	Download File View File

SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-09
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH3

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1CA8 \| pdb_00001ca8	Download File View File

Thrombin inhibitors with rigid tripeptidyl aldehydes

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

(1998) Biochemistry 37: 12094-12103

Released	1999-04-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	0KV, NA

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1CEA \| pdb_00001cea	Download File View File

THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)

Tulinsky, A., Mathews, I.I.

(1996) Biochemistry 35: 2567-2576

Released	1996-04-03
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	PLASMINOGEN (protein)
Unique Ligands	ACA

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1CEB \| pdb_00001ceb	Download File View File

THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)

Tulinsky, A., Mathews, I.I.

(1996) Biochemistry 35: 2567-2576

Released	1996-04-03
Method	X-RAY DIFFRACTION 2.07 Å
Organisms	Homo sapiens
Macromolecule	PLASMINOGEN (protein)
Unique Ligands	AMH

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1CLP \| pdb_00001clp	Download File View File

CRYSTAL STRUCTURE OF A CALCIUM-INDEPENDENT PHOSPHOLIPASELIKE MYOTOXIC PROTEIN FROM BOTHROPS ASPER VENOM

Arni, R.K., Ward, R.J., Gutierrez, J.M., Tulinsky, A.

(1995) Acta Crystallogr D Biol Crystallogr 51: 311-317

Released	1994-11-30
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Bothrops asper
Macromolecule	MYOTOXIN II (protein)

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1D0D \| pdb_00001d0d	Download File View File

CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR

St.Charles, R., Padmanabhan, K., Arni, R.V., Padmanabhan, K.P., Tulinsky, A.

(2000) Protein Sci 9: 265-272

Released	2000-09-09
Method	X-RAY DIFFRACTION 1.62 Å
Organisms	Bos taurus Ornithodoros moubata
Macromolecule	ANTICOAGULANT PROTEIN (protein) PANCREATIC TRYPSIN INHIBITOR (protein)
Unique Ligands	SO4

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1D6W \| pdb_00001d6w	Download File View File

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

Mochalkin, I., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	DECAPEPTIDE INHIBITOR (protein) THROMBIN (protein)
Unique Ligands	00R, NA

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1D9I \| pdb_00001d9i	Download File View File

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

Krishnan, R., Mochalkin, I., Arni, R., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	00P, NA

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1DIT \| pdb_00001dit	Download File View File

COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN

Tulinsky, A., Krishnan, R.

(1996) Protein Sci 5: 422-433

Released	1996-06-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	ALPHA-THROMBIN (protein) PEPTIDE INHIBITOR CVS995 (protein)

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1DM4 \| pdb_00001dm4	Download File View File

SER195ALA MUTANT OF HUMAN THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A (7-16)

Krishnan, R., Sadler, E.J., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 406-410

Released	2000-01-19
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (ALPHA THROMBIN:LIGHT CHAIN) (protein) PROTEIN (FIBRINOPEPTIDE) (protein) PROTEIN (MUTANT ALPHA THROMBIN:HEAVY CHAIN) (protein)

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1FAK \| pdb_00001fak	Download File View File

HUMAN TISSUE FACTOR COMPLEXED WITH COAGULATION FACTOR VIIA INHIBITED WITH A BPTI-MUTANT

Zhang, E., St Charles, R., Tulinsky, A.

(1999) J Mol Biology 285: 2089-2104

Released	1999-12-03
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	PROTEIN (5L15) (protein) PROTEIN (BLOOD COAGULATION FACTOR VIIA) (protein) PROTEIN (SOLUBLE TISSUE FACTOR) (protein)
Unique Ligands	CA, FUC, GLC

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1FPC \| pdb_00001fpc	Download File View File

ACTIVE SITE MIMETIC INHIBITION OF THROMBIN

Tulinsky, A., Mathews, I.I.

(1995) Acta Crystallogr D Biol Crystallogr 51: 550-559

Released	1995-02-27
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin (protein) thrombin (protein)
Unique Ligands	0ZI

1 to 25 of 81 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1A2C | pdb_00001a2c

1A46 | pdb_00001a46

1A4W | pdb_00001a4w

1A5G | pdb_00001a5g

1A61 | pdb_00001a61

1ABI | pdb_00001abi

1ABJ | pdb_00001abj

1AY6 | pdb_00001ay6

1B5G | pdb_00001b5g

1BA8 | pdb_00001ba8

1BB0 | pdb_00001bb0

1C4U | pdb_00001c4u

1C4V | pdb_00001c4v

1C4Y | pdb_00001c4y

1CA8 | pdb_00001ca8

1CEA | pdb_00001cea

1CEB | pdb_00001ceb

1CLP | pdb_00001clp

1D0D | pdb_00001d0d

1D6W | pdb_00001d6w

1D9I | pdb_00001d9i

1DIT | pdb_00001dit

1DM4 | pdb_00001dm4

1FAK | pdb_00001fak

1FPC | pdb_00001fpc