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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Aoki, Y."

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Search Summary

This query matches 26 Structures.

Refinements

Structure Determination Methodology

experimental (26)

Scientific Name of Source Organism

	Homo sapiens (20)
	Candida albicans (2)
	Mus musculus (2)
	Rattus norvegicus (2)

Taxonomy

Eukaryota (26)

Experimental Method

X-RAY DIFFRACTION (26)

Polymer Entity Type

Protein (26)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (5)
	2.0 - 2.5 (10)
	2.5 - 3.0 (8)
	3.0 - 3.5 (2)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (2)
	2010 - 2014 (19)
	2015 - 2019 (1)
	2020 - 2024 (2)

Enzyme Classification Name

	Transferases (19)
	Hydrolases (5)

Symmetry Type

	Asymmetric (26)
	Cyclic (6)

SCOP Classification

	Alpha and beta proteins (a+b) (22)
	All beta proteins (13)
	Artifacts (10)
	All alpha proteins (7)
	Alpha and beta proteins (a/b) (2)

AllSelected

1 to 25 of 26 Structures

Page 1 of 2

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1IYK \| pdb_00001iyk	Download File View File

Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor

Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.

(2002) Chem Biol 9: 1119-1128

Released	2002-12-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Candida albicans
Macromolecule	MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE (protein)
Unique Ligands	MIM, MYA

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1IYL \| pdb_00001iyl	Download File View File

Crystal Structure of Candida albicans N-myristoyltransferase with Non-peptidic Inhibitor

Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.

(2002) Chem Biol 9: 1119-1128

Released	2002-12-30
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Candida albicans
Macromolecule	Myristoyl-CoA:Protein N-Myristoyltransferase (protein)
Unique Ligands	R64

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2ZIR \| pdb_00002zir	Download File View File

Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP

Fukami, T.A., Sogabe, S., Nagata, Y., Kondoh, O., Ishii, N.

(2009) Bioorg Med Chem Lett 19: 1753-1757

Released	2009-02-24
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase subunit alpha (protein) Protein farnesyltransferase subunit beta (protein)
Unique Ligands	FPP, GOL, NH7, ZN

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2ZIS \| pdb_00002zis	Download File View File

Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP

Fukami, T.A., Sogabe, S., Nagata, Y., Kondoh, O., Ishii, N.

(2009) Bioorg Med Chem Lett 19: 1753-1757

Released	2009-02-24
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Rattus norvegicus
Macromolecule	Protein farnesyltransferase subunit alpha (protein) Protein farnesyltransferase subunit beta (protein)
Unique Ligands	ACY, FPP, GOL, NH8, ZN

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3AOX \| pdb_00003aox	Download File View File

X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802

Nagel, S., Moertl, M., Jestel, A., Fukami, T.A.

(2011) Cancer Cell 19: 679-690

Released	2011-05-25
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	ALK tyrosine kinase receptor (protein)
Unique Ligands	EDO, EMH

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3APC \| pdb_00003apc	Download File View File

Crystal structure of human PI3K-gamma in complex with CH5132799

Nakamura, M., Fukami, T.A., Miyazaki, T., Yoshida, M.

(2011) Bioorg Med Chem Lett 21: 1767-1772

Released	2011-04-13
Method	X-RAY DIFFRACTION 2.544 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	MMD, SO4

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3APD \| pdb_00003apd	Download File View File

Crystal structure of human PI3K-gamma in complex with CH5108134

Nakamura, M., Fukami, T.A., Miyazaki, T., Yoshida, M.

(2011) Bioorg Med Chem Lett 21: 1767-1772

Released	2011-04-13
Method	X-RAY DIFFRACTION 2.55 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	MMY, SO4

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3APF \| pdb_00003apf	Download File View File

Crystal structure of human PI3K-gamma in complex with CH5039699

Nakamura, M., Fukami, T.A., Miyazaki, T., Yoshida, M.

(2011) Bioorg Med Chem Lett 21: 1767-1772

Released	2011-04-13
Method	X-RAY DIFFRACTION 2.82 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	BMW, SO4

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3B24 \| pdb_00003b24	Download File View File

Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule

Fukami, T.A., Ono, N.

(2011) Bioorg Med Chem Lett 21: 5778-5783

Released	2011-09-14
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	B2J, MG

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3B25 \| pdb_00003b25	Download File View File

Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194

Fukami, T.A., Ono, N.

(2011) Bioorg Med Chem Lett 21: 5778-5783

Released	2011-09-14
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	B2K

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3B26 \| pdb_00003b26	Download File View File

Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850

Fukami, T.A., Ono, N.

(2011) Bioorg Med Chem Lett 21: 5778-5783

Released	2011-09-14
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	B2L

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3B27 \| pdb_00003b27	Download File View File

Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127

Fukami, T.A., Ono, N.

(2011) Bioorg Med Chem Lett 21: 5778-5783

Released	2011-09-14
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	B2T

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3B28 \| pdb_00003b28	Download File View File

Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765

Fukami, T.A., Ono, N.

(2011) Bioorg Med Chem Lett 21: 5778-5783

Released	2011-09-14
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Homo sapiens
Macromolecule	Heat shock protein HSP 90-alpha (protein)
Unique Ligands	B2X, GOL, MG

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3VRY \| pdb_00003vry	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane

Kuratani, M., Tomabechi, Y., Niwa, H., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.481 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	B43, CA, CL

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3VRZ \| pdb_00003vrz	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea

Kuratani, M., Tomabechi, Y., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.218 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VRZ

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3VS0 \| pdb_00003vs0	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide

Kuratani, M., Honda, K., Tomabechi, Y., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.934 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VS0

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3VS1 \| pdb_00003vs1	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea

Kuratani, M., Tomabechi, Y., Toyama, M., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.464 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VSA

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3VS2 \| pdb_00003vs2	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Kuratani, M., Tomabechi, Y., Niwa, H., Parker, J.L., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.609 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VSB

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3VS3 \| pdb_00003vs3	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Kuratani, M., Tomaebchi, Y., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.17 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VSE

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3VS4 \| pdb_00003vs4	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Kuratani, M., Tomabechi, Y., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.747 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VSF

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3VS5 \| pdb_00003vs5	Download File View File

Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Kuratani, M., Tomabechi, Y., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.851 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, VSG

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3VS6 \| pdb_00003vs6	Download File View File

Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate

Kuratani, M., Honda, K., Tomabechi, Y., Toyama, M., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.373 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, VSH

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3VS7 \| pdb_00003vs7	Download File View File

Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Kuratani, M., Honda, K., Niwa, H., Toyama, M., Handa, N., Yokoyama, S.

(2013) Sci Transl Med 5: 181ra52-181ra52

Released	2013-05-01
Method	X-RAY DIFFRACTION 3.001 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein kinase HCK (protein)
Unique Ligands	CA, CL, KS1

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5B7V \| pdb_00005b7v	Download File View File

Human FGFR1 kinase in complex with CH5183284

Fukami, T.A., Lukacs, C.M., Janson, C.

(2014) Mol Cancer Ther 13: 2547-2558

Released	2016-06-22
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 1 (protein)
Unique Ligands	LWJ, SO4