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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Fitzgerald, M."

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

	Homo sapiens (18)
	Hirudo medicinalis (1)

Taxonomy

Eukaryota (18)

Experimental Method

	X-RAY DIFFRACTION (17)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (18)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (9)
	2.5 - 3.0 (2)
	3.0 - 3.5 (2)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (11)
	2020 - 2024 (6)

Enzyme Classification Name

	Transferases (15)
	Hydrolases (3)

Symmetry Type

Asymmetric (18)

SCOP Classification

Alpha and beta proteins (a+b) (13)

AllSelected

1 to 18 of 18 Structures

Page 1 of 1

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Explore in 3D

3C27 \| pdb_00003c27	Download File View File

Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors

Spurlino, J.C., McMillan, M., Lewandowski, F., Milligan, C.

To be published

Released	2009-02-17
Method	X-RAY DIFFRACTION 2.182 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	Hirudin-3A (protein) Thrombin heavy chain (protein) Thrombin light chain (protein)
Unique Ligands	DKK

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3R00 \| pdb_00003r00	Download File View File

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Liu, J.

(2011) Bioorg Med Chem Lett 21: 3050-3056

Released	2011-05-11
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	IMD, UNJ

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3R01 \| pdb_00003r01	Download File View File

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Liu, J.

(2011) Bioorg Med Chem Lett 21: 3050-3056

Released	2011-05-11
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	IMD, UNE

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3R02 \| pdb_00003r02	Download File View File

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Xiang, Y., Hirth, B., Asmussen, G., Biemann, H.-P., Good, A., Fitzgerald, M., Gladysheva, T., Jancsics, K., Liu, J., Metz, M., Papoulis, A., Skerlj, R., Stepp, D.J., Wei, R.R.

(2011) Bioorg Med Chem Lett 21: 3050-3056

Released	2011-05-11
Method	X-RAY DIFFRACTION 1.95 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	IMD, UNM

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3R04 \| pdb_00003r04	Download File View File

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

Xiang, Y., Hirth, B., Asmussen, G., Biemann, H.-P., Good, A., Fitzgerald, M., Gladysheva, T., Jancsics, K., Liu, J., Metz, M., Papoulis, A., Skerlj, R., Stepp, D.J., Wei, R.R.

(2011) Bioorg Med Chem Lett 21: 3050-3056

Released	2011-05-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	IMD, UNQ

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3VBQ \| pdb_00003vbq	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0F5

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3VBT \| pdb_00003vbt	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0F9

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3VBV \| pdb_00003vbv	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0FK

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3VBW \| pdb_00003vbw	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.48 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0FN

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3VBX \| pdb_00003vbx	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0FO

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3VBY \| pdb_00003vby	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0FR, IMD

Explore in 3D

3VC4 \| pdb_00003vc4	Download File View File

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

Liu, J.

(2012) J Med Chem 55: 2641-2648

Released	2012-03-21
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	0FS, IMD

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6V9C \| pdb_00006v9c	Download File View File

Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor

Liu, J., Liu, H.

(2020) ACS Med Chem Lett 11: 1899-1904

Released	2020-03-25
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Fibroblast growth factor receptor 4 (protein)
Unique Ligands	QS7, SO4

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6WXJ \| pdb_00006wxj	Download File View File

CSF1R signaling is a regulator of pathogenesis in progressive MS

Liu, J.

(2020) Cell Death Dis 11: 904-904

Released	2021-02-10
Method	X-RAY DIFFRACTION 2.62 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor (protein)
Unique Ligands	UF4

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7LGS \| pdb_00007lgs	Download File View File

Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.

Skene, R.J., Lane, W.

(2021) Cancer Discov 11: 1672-1687

Released	2021-09-22
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Homo sapiens
Macromolecule	Epidermal growth factor receptor (protein)
Unique Ligands	CIT, EDO, Q6K

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8U0H \| pdb_00008u0h	Download File View File

Crystal structure of PTPN2 with a PROTAC

Jain, R., Longenecker, K., Qiu, W.

(2024) Commun Chem 7: 183-183

Released	2024-09-04
Method	X-RAY DIFFRACTION 1.93 Å
Organisms	Homo sapiens
Macromolecule	PTPN2 (protein)
Unique Ligands	ACT, NA, UB0

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8UH6 \| pdb_00008uh6	Download File View File

Degrader-induced complex between PTPN2 and CRBN-DDB1

Catalano, C., Bratkowski, M., Scapin, G., Hao, Q.

(2024) Commun Chem 7: 183-183

Released	2024-09-11
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	DNA damage-binding protein 1 (protein) Protein cereblon (protein) Tyrosine-protein phosphatase non-receptor type 2 (protein)
Unique Ligands	WO8, ZN

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8W1L \| pdb_00008w1l	Download File View File

Structure of CSF1R kinase domain in complex with Cpd 32

Kothe, M., Chodaparambil, J.

(2024) ACS Med Chem Lett 15: 722-730

Released	2024-05-29
Method	X-RAY DIFFRACTION 2.26 Å
Organisms	Homo sapiens
Macromolecule	Macrophage colony-stimulating factor 1 receptor,CSF1R (protein)
Unique Ligands	A1AE3, GOL, SO4

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3C27 | pdb_00003c27

Cyanofluorophenylacetamides as Orally Efficacious Thrombin Inhibitors

3R00 | pdb_00003r00

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

3R01 | pdb_00003r01

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

3R02 | pdb_00003r02

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

3R04 | pdb_00003r04

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

3VBQ | pdb_00003vbq

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VBT | pdb_00003vbt

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VBV | pdb_00003vbv

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VBW | pdb_00003vbw

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VBX | pdb_00003vbx

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VBY | pdb_00003vby

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

3VC4 | pdb_00003vc4

Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design

6V9C | pdb_00006v9c

Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor

6WXJ | pdb_00006wxj

CSF1R signaling is a regulator of pathogenesis in progressive MS

7LGS | pdb_00007lgs

Structure of EGFR_D770_N771insNPG/V948R in complex with covalent inhibitor Osimertinib.

8U0H | pdb_00008u0h

Crystal structure of PTPN2 with a PROTAC

8UH6 | pdb_00008uh6

Degrader-induced complex between PTPN2 and CRBN-DDB1

8W1L | pdb_00008w1l

Structure of CSF1R kinase domain in complex with Cpd 32

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3C27 | pdb_00003c27

3R00 | pdb_00003r00

3R01 | pdb_00003r01

3R02 | pdb_00003r02

3R04 | pdb_00003r04

3VBQ | pdb_00003vbq

3VBT | pdb_00003vbt

3VBV | pdb_00003vbv

3VBW | pdb_00003vbw

3VBX | pdb_00003vbx

3VBY | pdb_00003vby

3VC4 | pdb_00003vc4

6V9C | pdb_00006v9c

6WXJ | pdb_00006wxj

7LGS | pdb_00007lgs

8U0H | pdb_00008u0h

8UH6 | pdb_00008uh6

8W1L | pdb_00008w1l