RCSB PDB: Search

1QC8 \| pdb_00001qc8	Download File View File

NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA

Varani, L., Spillantini, M.G., Klug, A., Goedert, M., Varani, G.

(1999) Proc Natl Acad Sci U S A 96: 8229-8234

Released	1999-08-31
Method	SOLUTION NMR
Macromolecule	TAU EXON 10 SPLICING REGULATORY ELEMENT RNA (nucleic acid)

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5O3L \| pdb_00005o3l	Download File View File

Paired helical filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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5O3O \| pdb_00005o3o	Download File View File

Pronase-treated paired helical filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.5 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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5O3T \| pdb_00005o3t	Download File View File

Straight filament in Alzheimer's disease brain

Fitzpatrick, A.W.P., Falcon, B., He, S., Murzin, A.G., Murshudov, G., Garringer, H.G., Crowther, R.A., Ghetti, B., Goedert, M., Scheres, S.H.W.

(2017) Nature 547: 185-190

Released	2017-07-26
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6GX5 \| pdb_00006gx5	Download File View File

Narrow Pick Filament from Pick's disease brain

Falcon, B., Zhang, W., Murzin, A.G., Murshudov, G., Garringer, H.J., Vidal, R., Crowther, R.A., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Nature 561: 137-140

Released	2018-09-12
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6HRE \| pdb_00006hre	Download File View File

Paired helical filament from sporadic Alzheimer's disease brain

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A.G., Vidal, R., Garringer, H.J., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Acta Neuropathol 136: 699-708

Released	2018-10-10
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6HRF \| pdb_00006hrf	Download File View File

Straight filament from sporadic Alzheimer's disease brain

Falcon, B., Zhang, W., Schweighauser, M., Murzin, A.G., Vidal, R., Garringer, H.J., Ghetti, B., Scheres, S.H.W., Goedert, M.

(2018) Acta Neuropathol 136: 699-708

Released	2018-10-10
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6NWP \| pdb_00006nwp	Download File View File

Chronic traumatic encephalopathy Type I Tau filament

Falcon, B., Zivanov, J., Zhang, W., Murzin, A.G., Garringer, H.J., Vidal, R., Crowther, R.A., Newell, K.L., Ghetti, B., Goedert, M., Scheres, H.W.

(2019) Nature 568: 420-423

Released	2019-03-27
Method	ELECTRON MICROSCOPY 2.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6NWQ \| pdb_00006nwq	Download File View File

Chronic traumatic encephalopathy Type II Tau filament

Falcon, B., Zivanov, J., Zhang, W., Murzin, A.G., Garringer, H.J., Vidal, R., Crowther, R.A., Newell, K.L., Ghetti, B., Goedert, M., Scheres, H.W.

(2019) Nature 568: 420-423

Released	2019-03-27
Method	ELECTRON MICROSCOPY 3.4 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6ODG \| pdb_00006odg	Download File View File

SVQIVY, Crystal Structure of a tau protein fragment

Eisenberg, D.S., Boyer, D.R., Sawaya, M.R., Seidler, P.M.

(2019) J Biological Chem 294: 16451-16464

Released	2019-10-02
Method	X-RAY DIFFRACTION 1 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6PIL \| pdb_00006pil	Download File View File

Antibody scFv-M204 monomeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-24
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)
Unique Ligands	CL

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6PK8 \| pdb_00006pk8	Download File View File

Antibody scFv-M204 dimeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-24
Method	X-RAY DIFFRACTION 2.91 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)
Unique Ligands	SO4

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6PSC \| pdb_00006psc	Download File View File

Antibody scFv-M204 trimeric state

Abskharon, R., Sawaya, M.R., Seidler, P.M., Cascio, D., Eisenberg, D.S.

(2020) J Biological Chem 295: 10662-10676

Released	2020-06-17
Method	X-RAY DIFFRACTION 3.6 Å
Organisms	Oryctolagus cuniculus
Macromolecule	scFv-M204 antibody (protein)

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6TJO \| pdb_00006tjo	Download File View File

Cryo-EM structure of TypeI tau filaments extracted from the brains of individuals with Corticobasal degeneration

Zhang, W., Murzin, A.G., Falcon, B., Shi, Y., Goedert, M., Scheres, S.H.W.

(2020) Nature 580: 283-287

Released	2020-02-05
Method	ELECTRON MICROSCOPY 3.2 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6TJX \| pdb_00006tjx	Download File View File

Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with Corticobasal degeneration

Zhang, W., Murzin, A.G., Falcon, B., Shi, Y., Goedert, M., Scheres, S.H.W.

(2020) Nature 580: 283-287

Released	2020-02-05
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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6VI3 \| pdb_00006vi3	Download File View File

Straight Filament from Alzheimer's Disease Human Brain Tissue

Arakhamia, T., Lee, C.E., Carlomagno, Y., Duong, D.M., Kundinger, S.R., Wang, K., Williams, D., DeTure, M., Dickson, D.W., Cook, C.N., Seyfried, N.T., Petrucelli, L., Fitzpatrick, A.W.P.

(2020) Cell 180: 633-644.e12

Released	2020-04-15
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)
Unique Ligands	GLY

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6XYO \| pdb_00006xyo	Download File View File

Multiple system atrophy Type I alpha-synuclein filament

Schweighauser, M., Shi, Y., Tarutani, A., Kametani, F., Murzin, A.G., Ghetti, B., Matsubara, T., Tomita, T., Ando, T., Hasegawa, K., Murayama, S., Yoshida, M., Hasegawa, M., Scheres, S.H.W., Goedert, M.

(2020) Nature 585: 464-469

Released	2020-02-12
Method	ELECTRON MICROSCOPY 2.6 Å
Organisms	Homo sapiens
Macromolecule	Alpha-synuclein (protein)

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6XYP \| pdb_00006xyp	Download File View File

Multiple system atrophy Type II-1 alpha-synuclein filament

Schweighauser, M., Shi, Y., Tarutani, A., Kametani, F., Murzin, A.G., Ghetti, B., Matsubara, T., Tomita, T., Ando, T., Hasegawa, K., Murayama, S., Yoshida, M., Hasegawa, M., Scheres, S.H.W., Goedert, M.

(2020) Nature 585: 464-469

Released	2020-02-12
Method	ELECTRON MICROSCOPY 3.29 Å
Organisms	Homo sapiens
Macromolecule	Alpha-synuclein (protein)

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6XYQ \| pdb_00006xyq	Download File View File

Multiple system atrophy Type II-2 alpha-synuclein filament

Schweighauser, M., Shi, Y., Tarutani, A., Kametani, F., Murzin, A.G., Ghetti, B., Matsubara, T., Tomita, T., Ando, T., Hasegawa, K., Murayama, S., Yoshida, M., Hasegawa, M., Scheres, S.H.W., Goedert, M.

(2020) Nature 585: 464-469

Released	2020-02-12
Method	ELECTRON MICROSCOPY 3.09 Å
Organisms	Homo sapiens
Macromolecule	Alpha-synuclein (protein)

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7MKF \| pdb_00007mkf	Download File View File

Paired helical tau filament extracted from PrP-CAA Patient brain tissue | tau filament | PHF Tau

Hoq, M.R.

(2021) Acta Neuropathol 142: 227-241

Released	2021-07-28
Method	ELECTRON MICROSCOPY 3 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)

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7MKG \| pdb_00007mkg	Download File View File

Straight tau filament extracted from PrP-CAA Patient brain tissue | tau filament | SF Tau

Hoq, M.R.

(2021) Acta Neuropathol 142: 227-241

Released	2021-07-28
Method	ELECTRON MICROSCOPY 3.07 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)

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7MKH \| pdb_00007mkh	Download File View File

Paired helical tau filament extracted from GSS Patient brain tissue | tau filament from Gerstmann Straussler Scheinker disease | PHF Tau

Hoq, M.R.

(2021) Acta Neuropathol 142: 227-241

Released	2021-07-28
Method	ELECTRON MICROSCOPY 3.3 Å
Organisms	Homo sapiens
Macromolecule	Isoform Tau-F of Microtubule-associated protein tau (protein)

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7NRQ \| pdb_00007nrq	Download File View File

Paired helical filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.76 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRS \| pdb_00007nrs	Download File View File

Conformation 1 of straight filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.68 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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7NRT \| pdb_00007nrt	Download File View File

Conformation 2 of straight filament from primary age-related tauopathy brain

Shi, Y., Murzin, A.G., Falcon, B., Epstein, A., Machin, J., Tempest, P., Newell, K.L., Vidal, R., Garringer, H.J., Sahara, N., Higuchi, M., Ghetti, B., Jang, M., Scheres, S.H.W., Goedert, M.

(2021) Acta Neuropathol 141: 697-708

Released	2021-03-24
Method	ELECTRON MICROSCOPY 2.68 Å
Organisms	Homo sapiens
Macromolecule	Microtubule-associated protein tau (protein)

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Symmetry Type

SCOP Classification

1QC8 | pdb_00001qc8

5O3L | pdb_00005o3l

5O3O | pdb_00005o3o

5O3T | pdb_00005o3t

6GX5 | pdb_00006gx5

6HRE | pdb_00006hre

6HRF | pdb_00006hrf

6NWP | pdb_00006nwp

6NWQ | pdb_00006nwq

6ODG | pdb_00006odg

6PIL | pdb_00006pil

6PK8 | pdb_00006pk8

6PSC | pdb_00006psc

6TJO | pdb_00006tjo

6TJX | pdb_00006tjx

6VI3 | pdb_00006vi3

6XYO | pdb_00006xyo

6XYP | pdb_00006xyp

6XYQ | pdb_00006xyq

7MKF | pdb_00007mkf

7MKG | pdb_00007mkg

7MKH | pdb_00007mkh

7NRQ | pdb_00007nrq

7NRS | pdb_00007nrs

7NRT | pdb_00007nrt