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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Giraldes, J."

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Search Summary

This query matches 10 Structures.

Refinements

Structure Determination Methodology

experimental (10)

Scientific Name of Source Organism

Homo sapiens (10)

Taxonomy

Eukaryota (10)

Experimental Method

X-RAY DIFFRACTION (10)

Polymer Entity Type

Protein (10)

Refinement Resolution (Å)

	1.5 - 2.0 (5)
	2.0 - 2.5 (4)
	2.5 - 3.0 (1)

Release Date

	2010 - 2014 (2)
	2015 - 2019 (6)
	2020 - 2024 (2)

Enzyme Classification Name

	Transferases (7)
	Hydrolases (2)
	Oxidoreductases (1)

Symmetry Type

	Asymmetric (9)
	Cyclic (1)

SCOP Classification

	Alpha and beta proteins (a+b) (9)
	Alpha and beta proteins (a/b) (3)

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1 to 10 of 10 Structures

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4AUA \| pdb_00004aua	Download File View File

Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)

Cho, Y.S., Angove, H., Brain, C., Chen, C.H.T., Cheng, R., Chopra, R., Chung, K., Congreve, M., Dagostin, C., Davis, D., Feltell, R., Giraldes, J., Hiscock, S., Kim, S., Kovats, S., Lagu, B., Lewry, K., Loo, A., Lu, Y., Luzzio, M., Maniara, W., Mcmenamin, R., Mortenson, P., Benning, R., O'Reilly, M., Rees, D., Shen, J., Smith, T., Wang, Y., Williams, G., Woolford, A., Wrona, W., Xu, M., Yang, F., Howard, S.

(2012) ACS Med Chem Lett 3: 445-449

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 6 (protein)
Unique Ligands	4AU

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4EZ5 \| pdb_00004ez5	Download File View File

CDK6 (monomeric) in complex with inhibitor

Chopra, R., Xu, M.

(2012) ACS Med Chem Lett 3: 445-449

Released	2013-02-06
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 6 (protein)
Unique Ligands	0RS

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5IH8 \| pdb_00005ih8	Download File View File

MELK in complex with NVS-MELK1

Sprague, E.R., Puleo, D.E.

(2016) J Med Chem 59: 4711-4723

Released	2016-06-01
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Maternal embryonic leucine zipper kinase (protein)
Unique Ligands	6BJ

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5IH9 \| pdb_00005ih9	Download File View File

MELK in complex with NVS-MELK8A

Sprague, E.R., Puleo, D.E.

(2016) J Med Chem 59: 4711-4723

Released	2016-06-01
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	Maternal embryonic leucine zipper kinase (protein)
Unique Ligands	6BF

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5IHA \| pdb_00005iha	Download File View File

MELK in complex with NVS-MELK8F

Sprague, E.R., Brazell, T.

(2016) J Med Chem 59: 4711-4723

Released	2016-06-01
Method	X-RAY DIFFRACTION 1.96 Å
Organisms	Homo sapiens
Macromolecule	Maternal embryonic leucine zipper kinase (protein)
Unique Ligands	6BE

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5IHC \| pdb_00005ihc	Download File View File

MELK in complex with NVS-MELK12B

Sprague, E.R., Brazell, T.

(2016) J Med Chem 59: 4711-4723

Released	2016-06-01
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Homo sapiens
Macromolecule	Maternal embryonic leucine zipper kinase (protein)
Unique Ligands	6BB

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5K00 \| pdb_00005k00	Download File View File

MELK in complex with NVS-MELK5

Sprague, E.R.

(2017) J Med Chem 60: 2155-2161

Released	2017-03-01
Method	X-RAY DIFFRACTION 1.77 Å
Organisms	Homo sapiens
Macromolecule	Maternal embryonic leucine zipper kinase (protein)
Unique Ligands	6PV

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5TQH \| pdb_00005tqh	Download File View File

IDH1 R132H mutant in complex with IDH889

Xie, X., Kulathila, R.

(2017) ACS Med Chem Lett 8: 151-156

Released	2017-01-25
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Isocitrate dehydrogenase [NADP] cytoplasmic (protein)
Unique Ligands	7J2, FLC, NDP

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7JVM \| pdb_00007jvm	Download File View File

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155

Fodor, M., Stams, T.

(2020) J Med Chem 63: 13578-13594

Released	2020-09-23
Method	X-RAY DIFFRACTION 2.166 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	PO4, VKS

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7JVN \| pdb_00007jvn	Download File View File

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24

Fodor, M., Stams, T.

(2020) J Med Chem 63: 13578-13594

Released	2020-09-23
Method	X-RAY DIFFRACTION 1.917 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	PO4, VKP

1 to 10 of 10 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4AUA | pdb_00004aua

Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6)

4EZ5 | pdb_00004ez5

CDK6 (monomeric) in complex with inhibitor

5IH8 | pdb_00005ih8

MELK in complex with NVS-MELK1

5IH9 | pdb_00005ih9

MELK in complex with NVS-MELK8A

5IHA | pdb_00005iha

MELK in complex with NVS-MELK8F

5IHC | pdb_00005ihc

MELK in complex with NVS-MELK12B

5K00 | pdb_00005k00

MELK in complex with NVS-MELK5

5TQH | pdb_00005tqh

IDH1 R132H mutant in complex with IDH889

7JVM | pdb_00007jvm

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155

7JVN | pdb_00007jvn

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4AUA | pdb_00004aua

4EZ5 | pdb_00004ez5

5IH8 | pdb_00005ih8

5IH9 | pdb_00005ih9

5IHA | pdb_00005iha

5IHC | pdb_00005ihc

5K00 | pdb_00005k00

5TQH | pdb_00005tqh

7JVM | pdb_00007jvm

7JVN | pdb_00007jvn