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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Houze, J."

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Search Summary

This query matches 20 Structures.

Refinements

Structure Determination Methodology

experimental (20)

Scientific Name of Source Organism

Homo sapiens (20)

Taxonomy

Eukaryota (20)

Experimental Method

	X-RAY DIFFRACTION (19)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (20)

Refinement Resolution (Å)

	1.0 - 1.5 (4)
	1.5 - 2.0 (12)
	2.0 - 2.5 (3)

Release Date

	2010 - 2014 (7)
	2015 - 2019 (13)

Enzyme Classification Name

	Ligases (7)
	Transferases (7)

Symmetry Type

	Asymmetric (20)
	Cyclic (7)

SCOP Classification

	Membrane and cell surface proteins and peptides (13)
	All alpha proteins (7)
	Artifacts (2)

AllSelected

1 to 20 of 20 Structures

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Explore in 3D

4OCC \| pdb_00004occ	Download File View File

co-crystal structure of MDM2(17-111) in complex with compound 48

Huang, X.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2TZ

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4ODE \| pdb_00004ode	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 4

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U0, SO4

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4ODF \| pdb_00004odf	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 47

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.2006 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U1

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4OGN \| pdb_00004ogn	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 3

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.377 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U5, SO4

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4OGT \| pdb_00004ogt	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.5361 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U6, SO4

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4OGV \| pdb_00004ogv	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 49

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.197 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U7

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4WT2 \| pdb_00004wt2	Download File View File

Co-crystal Structure of MDM2 in Complex with AM-7209

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 10499-10511

Released	2014-12-03
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	3UD, SO4

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6O6F \| pdb_00006o6f	Download File View File

Co-crystal structure of Mcl1 with inhibitor

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LOD

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6O6G \| pdb_00006o6g	Download File View File

Co-crystal structure of Mcl1 with inhibitor

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LOJ

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6OQB \| pdb_00006oqb	Download File View File

Co-crystal structure of Mcl1 with inhibitor 10

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0J

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6OQD \| pdb_00006oqd	Download File View File

Crystal structure of Mcl1 with inhibitor 8

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.48 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0M

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6OQN \| pdb_00006oqn	Download File View File

Crystal structure of Mcl1 with inhibitor 7

Huang, X.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-15
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N0P

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6OVC \| pdb_00006ovc	Download File View File

hMcl1 inhibitor complex

Poppe, L.

(2018) Cancer Discov 8: 1582-1597

Released	2019-05-22
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	N8J

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6UD2 \| pdb_00006ud2	Download File View File

co-crystal structure of compound 1 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4D

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6UDI \| pdb_00006udi	Download File View File

X-ray co-crystal structure of compound 20 with Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4S

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6UDT \| pdb_00006udt	Download File View File

X-ray co-crystal structure of compound 10 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4V

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6UDU \| pdb_00006udu	Download File View File

X-ray co-crystal structure of compound 8 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4Y

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6UDV \| pdb_00006udv	Download File View File

X-ray co-crystal structure of compound 3 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q51

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6UDX \| pdb_00006udx	Download File View File

X-ray co-crystal structure of compound 7 with Mcl-1

Huang, X.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q57

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6UDY \| pdb_00006udy	Download File View File

X-ray co-crystal structure of compound 5 with Mcl-1

Huang, X.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q54

1 to 20 of 20 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4OCC | pdb_00004occ

co-crystal structure of MDM2(17-111) in complex with compound 48

4ODE | pdb_00004ode

Co-Crystal Structure of MDM2 with Inhibitor Compound 4

4ODF | pdb_00004odf

Co-Crystal Structure of MDM2 with Inhibitor Compound 47

4OGN | pdb_00004ogn

Co-Crystal Structure of MDM2 with Inhbitor Compound 3

4OGT | pdb_00004ogt

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

4OGV | pdb_00004ogv

Co-Crystal Structure of MDM2 with Inhibitor Compound 49

4WT2 | pdb_00004wt2

Co-crystal Structure of MDM2 in Complex with AM-7209

6O6F | pdb_00006o6f

Co-crystal structure of Mcl1 with inhibitor

6O6G | pdb_00006o6g

Co-crystal structure of Mcl1 with inhibitor

6OQB | pdb_00006oqb

Co-crystal structure of Mcl1 with inhibitor 10

6OQD | pdb_00006oqd

Crystal structure of Mcl1 with inhibitor 8

6OQN | pdb_00006oqn

Crystal structure of Mcl1 with inhibitor 7

6OVC | pdb_00006ovc

hMcl1 inhibitor complex

6UD2 | pdb_00006ud2

co-crystal structure of compound 1 bound to human Mcl-1

6UDI | pdb_00006udi

X-ray co-crystal structure of compound 20 with Mcl-1

6UDT | pdb_00006udt

X-ray co-crystal structure of compound 10 bound to human Mcl-1

6UDU | pdb_00006udu

X-ray co-crystal structure of compound 8 bound to human Mcl-1

6UDV | pdb_00006udv

X-ray co-crystal structure of compound 3 bound to human Mcl-1

6UDX | pdb_00006udx

X-ray co-crystal structure of compound 7 with Mcl-1

6UDY | pdb_00006udy

X-ray co-crystal structure of compound 5 with Mcl-1

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

4OCC | pdb_00004occ

4ODE | pdb_00004ode

4ODF | pdb_00004odf

4OGN | pdb_00004ogn

4OGT | pdb_00004ogt

4OGV | pdb_00004ogv

4WT2 | pdb_00004wt2

6O6F | pdb_00006o6f

6O6G | pdb_00006o6g

6OQB | pdb_00006oqb

6OQD | pdb_00006oqd

6OQN | pdb_00006oqn

6OVC | pdb_00006ovc

6UD2 | pdb_00006ud2

6UDI | pdb_00006udi

6UDT | pdb_00006udt

6UDU | pdb_00006udu

6UDV | pdb_00006udv

6UDX | pdb_00006udx

6UDY | pdb_00006udy