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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Jain, C.K."

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Search Summary

This query matches 15 Structures.

Refinements

Structure Determination Methodology

experimental (15)

Scientific Name of Source Organism

Homo sapiens (15)

Taxonomy

Eukaryota (15)

Experimental Method

	X-RAY DIFFRACTION (14)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (15)

Refinement Resolution (Å)

	1.5 - 2.0 (1)
	2.0 - 2.5 (6)
	2.5 - 3.0 (5)
	3.0 - 3.5 (1)
	3.5 - 4.0 (2)

Release Date

	2015 - 2019 (3)
	2020 - 2024 (12)

Enzyme Classification Name

	Transferases (9)
	Hydrolases (4)

Symmetry Type

	Asymmetric (15)
	Cyclic (1)
	Dihedral (1)

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1 to 15 of 15 Structures

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4WV5 \| pdb_00004wv5	Download File View File

HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN

Kirby, C., Stams, T., Baird, J.

(2015) Chem Biol 22: 87-97

Released	2015-01-14
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Homo sapiens
Macromolecule	Heat shock 70 kDa protein 1A/1B (protein)
Unique Ligands	GOL

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4WV7 \| pdb_00004wv7	Download File View File

HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN WITH COVALENTLY LINKED NOVOLACTONE

Kirby, C.A., Baird, J., Stams, T.

(2015) Chem Biol 22: 87-97

Released	2015-01-14
Method	X-RAY DIFFRACTION 2.42 Å
Organisms	Homo sapiens
Macromolecule	Heat shock 70 kDa protein 1A/1B (protein)
Unique Ligands	3UM

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5FA5 \| pdb_00005fa5	Download File View File

Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide

Sprague, E.R., McNamara, J.T.

(2016) Science 351: 1208-1213

Released	2016-02-24
Method	X-RAY DIFFRACTION 2.34 Å
Organisms	Homo sapiens
Macromolecule	Histone H4 (protein) Methylosome protein 50 (protein) Protein arginine N-methyltransferase 5 (protein)
Unique Ligands	MTA

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8T6D \| pdb_00008t6d	Download File View File

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

Tang, Y., Nguyen, V., Wilbur, J.D.

(2023) J Med Chem 66: 13384-13399

Released	2023-10-11
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	SO4, YR2

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8T6G \| pdb_00008t6g	Download File View File

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

Tang, Y., Nugyen, V., Wilbur, J.D.

(2023) J Med Chem 66: 13384-13399

Released	2023-10-11
Method	X-RAY DIFFRACTION 1.84 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	SO4, YT2

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8T7Q \| pdb_00008t7q	Download File View File

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

Tang, Y., Nguyen, V., Wilbur, J.D.

(2023) J Med Chem 66: 13384-13399

Released	2023-10-11
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	ZH5

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8T8Q \| pdb_00008t8q	Download File View File

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

Tang, Y., Nguyen, V., Wilbur, J.D.

(2023) J Med Chem 66: 13384-13399

Released	2023-10-11
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	Tyrosine-protein phosphatase non-receptor type 11 (protein)
Unique Ligands	ZJX

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8TS7 \| pdb_00008ts7	Download File View File

Human PI3K p85alpha/p110alpha

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.71 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)

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8TS8 \| pdb_00008ts8	Download File View File

p85alpha/p110alpha heterodimer H1047R mutant

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.72 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)

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8TS9 \| pdb_00008ts9	Download File View File

Human PI3K p85alpha/p110alpha H1047R bound to compound 1

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.83 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	UE9

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8TSA \| pdb_00008tsa	Download File View File

Human PI3K p85alpha/p110alpha H1047R bound to compound 2

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J., Valverde, R.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.51 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	UIW

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8TSB \| pdb_00008tsb	Download File View File

Human PI3K p85alpha/p110alpha bound to compound 2

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 3.53 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	UIW

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8TSC \| pdb_00008tsc	Download File View File

Human PI3K p85alpha/p110alpha H1047R bound to compound 3

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 3.62 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	UJC

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8TSD \| pdb_00008tsd	Download File View File

Human PI3K p85alpha/p110alpha bound to RLY-2608

Holliday, M., Tang, Y., Bulku, A., Wilbur, J., Fraser, J.

(2024) Cancer Discov 14: 240-257

Released	2023-11-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)
Unique Ligands	XUZ

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8TU6 \| pdb_00008tu6	Download File View File

CryoEM structure of PI3Kalpha

Valverde, R., Shi, H., Holliday, M.

(2024) Cancer Discov 14: 240-257

Released	2023-11-15
Method	ELECTRON MICROSCOPY 3.12 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 3-kinase regulatory subunit alpha (protein) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (protein)

1 to 15 of 15 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

4WV5 | pdb_00004wv5

HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN

4WV7 | pdb_00004wv7

HEAT SHOCK PROTEIN 70 SUBSTRATE BINDING DOMAIN WITH COVALENTLY LINKED NOVOLACTONE

5FA5 | pdb_00005fa5

Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide

8T6D | pdb_00008t6d

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

8T6G | pdb_00008t6g

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

8T7Q | pdb_00008t7q

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

8T8Q | pdb_00008t8q

Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors

8TS7 | pdb_00008ts7

Human PI3K p85alpha/p110alpha

8TS8 | pdb_00008ts8

p85alpha/p110alpha heterodimer H1047R mutant

8TS9 | pdb_00008ts9

Human PI3K p85alpha/p110alpha H1047R bound to compound 1

8TSA | pdb_00008tsa

Human PI3K p85alpha/p110alpha H1047R bound to compound 2

8TSB | pdb_00008tsb

Human PI3K p85alpha/p110alpha bound to compound 2

8TSC | pdb_00008tsc

Human PI3K p85alpha/p110alpha H1047R bound to compound 3

8TSD | pdb_00008tsd

Human PI3K p85alpha/p110alpha bound to RLY-2608

8TU6 | pdb_00008tu6

CryoEM structure of PI3Kalpha

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

4WV5 | pdb_00004wv5

4WV7 | pdb_00004wv7

5FA5 | pdb_00005fa5

8T6D | pdb_00008t6d

8T6G | pdb_00008t6g

8T7Q | pdb_00008t7q

8T8Q | pdb_00008t8q

8TS7 | pdb_00008ts7

8TS8 | pdb_00008ts8

8TS9 | pdb_00008ts9

8TSA | pdb_00008tsa

8TSB | pdb_00008tsb

8TSC | pdb_00008tsc

8TSD | pdb_00008tsd

8TU6 | pdb_00008tu6