RCSB PDB: Search

(2014) J Med Chem 57: 1170

Released	2011-05-04
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	TYROSINE-PROTEIN KINASE RECEPTOR (protein)
Unique Ligands	VGH

2YHV \| pdb_00002yhv	Download File View File

Structure of L1196M Mutant Anaplastic Lymphoma Kinase

(2014) J Med Chem 57: 1170

Released	2011-05-18
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)

4ANL \| pdb_00004anl	Download File View File

Structure of G1269A Mutant Anaplastic Lymphoma Kinase

(2014) J Med Chem 57: 1170

Released	2013-03-27
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)

4ANQ \| pdb_00004anq	Download File View File

Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

(2014) J Med Chem 57: 1170

Released	2013-03-27
Method	X-RAY DIFFRACTION 1.76 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	VGH

4CCB \| pdb_00004ccb	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with 3-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl-1H- pyrazol-4-yl)pyridin-2-amine

McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.

(2014) J Med Chem 57: 1170

Released	2014-01-29
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	OFG

4CCU \| pdb_00004ccu	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol

McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.

(2014) J Med Chem 57: 1170

Released	2014-01-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	AWF

4CD0 \| pdb_00004cd0	Download File View File

Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with 2-(5-(6-amino-5-((R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2- yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol

McTigue, M., Deng, Y., Liu, W., Brooun, A., Stewart, A.

(2014) J Med Chem 57: 1170

Released	2014-01-29
Method	X-RAY DIFFRACTION 2.23 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	AWJ

4CLI \| pdb_00004cli	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with PF- 06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	5P8

4CLJ \| pdb_00004clj	Download File View File

Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 1170

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.66 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	5P8

4CMO \| pdb_00004cmo	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 2-((1R)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-N-methylbenzamide

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	YPW

4CMT \| pdb_00004cmt	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.73 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	GWH

4CMU \| pdb_00004cmu	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (10R)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro- 1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecin-15(10H)-one

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	IV7

4CNH \| pdb_00004cnh	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 3-((1R)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1H- 1,2,3-triazol-5-yl)pyridin-2-amine

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	3U9

4CTB \| pdb_00004ctb	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor (5R)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	KVC

4CTC \| pdb_00004ctc	Download File View File

Structure of the Human Anaplastic Lymphoma Kinase in Complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10H)-one

McTigue, M.A., Deng, Y.L., Liu, W., Brooun, A., Stewart, A.E.

(2014) J Med Chem 57: 4720

Released	2014-05-28
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	ALK TYROSINE KINASE RECEPTOR (protein)
Unique Ligands	J99

5KZ0 \| pdb_00005kz0	Download File View File

Structure of Human Anaplastic Lymphoma Kinase in Complex With 2-[(1R)-1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]-4-fluoro-N,N-dimethylbenzamide

(2014) J Med Chem 57: 4720-4744

Released	2016-08-17
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	ALK tyrosine kinase receptor (protein)
Unique Ligands	6YL

5L2I \| pdb_00005l2i	Download File View File

The X-ray co-crystal structure of human CDK6 and Palbociclib.

Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.

(2016) Mol Cancer Ther 15: 2273-2281

Released	2016-08-24
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 6 (protein)
Unique Ligands	LQQ

5L2S \| pdb_00005l2s	Download File View File

The X-ray co-crystal structure of human CDK6 and Abemaciclib.

Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.

(2016) Mol Cancer Ther 15: 2273-2281

Released	2016-08-24
Method	X-RAY DIFFRACTION 2.27 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 6 (protein)
Unique Ligands	6ZV

5L2T \| pdb_00005l2t	Download File View File

The X-ray co-crystal structure of human CDK6 and Ribociclib.

Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.

(2016) Mol Cancer Ther 15: 2273-2281

Released	2016-08-24
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 6 (protein)
Unique Ligands	6ZZ

5L2W \| pdb_00005l2w	Download File View File

The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.

Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.

(2016) Mol Cancer Ther 15: 2273-2281

Released	2016-08-24
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Cyclin-dependent kinase 2 (protein) G1/S-specific cyclin-E1 (protein)
Unique Ligands	1QK, GOL

6M56 \| pdb_00006m56	Download File View File

Solution NMR Structure of Peptide P9R

Yuen, K.Y., Zhao, H.J., Yung, T.M., Sze, K.H.

(2020) Nat Commun 11: 4252-4252

Released	2020-09-09
Method	SOLUTION NMR
Organisms	Mus musculus
Macromolecule	Peptide P9R (protein)

7MX7 \| pdb_00007mx7	Download File View File

PRMT5:MEP50 complexed with inhibitor PF-06939999

(2022) Mol Cancer Ther 21: 3-15

Released	2021-11-17
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Homo sapiens
Macromolecule	Methylosome protein 50 (protein) Protein arginine N-methyltransferase 5 (protein)
Unique Ligands	ZR1

7MXA \| pdb_00007mxa	Download File View File

PRMT5:MEP50 complexed with inhibitor PF-06855800

(2022) Mol Cancer Ther 21: 3-15

Released	2021-11-17
Method	X-RAY DIFFRACTION 2.713 Å
Organisms	Homo sapiens
Macromolecule	Methylosome protein 50 (protein) Protein arginine N-methyltransferase 5 (protein)
Unique Ligands	ZR4

7MXC \| pdb_00007mxc	Download File View File

PRMT5:MEP50 complexed with adenosine

(2022) Mol Cancer Ther 21: 3-15

Released	2021-11-17
Method	X-RAY DIFFRACTION 2.41 Å
Organisms	Homo sapiens
Macromolecule	Methylosome protein 50 (protein) Protein arginine N-methyltransferase 5 (protein)
Unique Ligands	ADN

7MXG \| pdb_00007mxg	Download File View File

PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800