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233,249 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Lo, M.C."

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Search Summary

This query matches 38 Structures.

Refinements

Structure Determination Methodology

experimental (38)

Scientific Name of Source Organism

	Homo sapiens (36)
	Bacillus subtilis (2)
	Herpesvirus saimiri (strain 11) (1)

Taxonomy

	Eukaryota (36)
	Bacteria (2)
	Duplodnaviria (1)

Experimental Method

X-RAY DIFFRACTION (38)

Polymer Entity Type

Protein (38)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (16)
	2.0 - 2.5 (14)
	2.5 - 3.0 (4)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (2)
	2010 - 2014 (18)
	2015 - 2019 (9)
	2020 - 2024 (9)

Enzyme Classification Name

	Transferases (30)
	Ligases (18)

Symmetry Type

	Asymmetric (34)
	Cyclic (8)
	Dihedral (1)

SCOP Classification

	All alpha proteins (19)
	Alpha and beta proteins (a/b) (2)
	Membrane and cell surface proteins and peptides (7)
	Artifacts (1)
	Alpha and beta proteins (a+b) (1)

AllSelected

1 to 25 of 38 Structures

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1KAM \| pdb_00001kam	Download File View File

Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase

Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.

(2002) J Biological Chem 277: 3698-3707

Released	2002-07-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bacillus subtilis
Macromolecule	NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE (protein)

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1KAQ \| pdb_00001kaq	Download File View File

Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase

Olland, A.M., Underwood, K.W., Czerwinski, R.M., Lo, M.C., Aulabaugh, A., Bard, J., Stahl, M.L., Somers, W.S., Sullivan, F.X., Chopra, R.

(2002) J Biological Chem 277: 3698-3707

Released	2002-07-12
Method	X-RAY DIFFRACTION 3.2 Å
Organisms	Bacillus subtilis
Macromolecule	NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE (protein)
Unique Ligands	DND

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4ERE \| pdb_00004ere	Download File View File

crystal structure of MDM2 (17-111) in complex with compound 23

Huang, X.

(2012) J Med Chem 55: 4936-4954

Released	2012-05-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	0R2, SO4

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4ERF \| pdb_00004erf	Download File View File

crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)

Huang, X.

(2012) J Med Chem 55: 4936-4954

Released	2012-05-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	0R3

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4JV7 \| pdb_00004jv7	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MN, SO4

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4JV9 \| pdb_00004jv9	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MO, SO4

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4JVE \| pdb_00004jve	Download File View File

Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MQ

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4JVR \| pdb_00004jvr	Download File View File

Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MT

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4JWR \| pdb_00004jwr	Download File View File

Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid

Shaffer, P.L.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MY

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4OAS \| pdb_00004oas	Download File View File

co-crystal structure of MDM2 (17-111) in complex with compound 25

Huang, X.

(2014) J Med Chem 57: 1454-1472

Released	2014-02-19
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2SW, SO4

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4OBA \| pdb_00004oba	Download File View File

Co-crystal structure of MDM2 with Inhibitor Compound 4

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2472-2488

Released	2014-03-19
Method	X-RAY DIFFRACTION 1.602 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2TW

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4OCC \| pdb_00004occ	Download File View File

co-crystal structure of MDM2(17-111) in complex with compound 48

Huang, X.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2TZ

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4ODE \| pdb_00004ode	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 4

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U0, SO4

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4ODF \| pdb_00004odf	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 47

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.2006 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U1

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4OGN \| pdb_00004ogn	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 3

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.377 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U5, SO4

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4OGT \| pdb_00004ogt	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.5361 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U6, SO4

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4OGV \| pdb_00004ogv	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 49

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.197 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U7

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4QO4 \| pdb_00004qo4	Download File View File

co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Huang, X.

(2014) ACS Med Chem Lett 5: 894-899

Released	2014-07-16
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	35S

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4QOC \| pdb_00004qoc	Download File View File

crystal structure of compound 16 bound to MDM2(17-111), {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PYRROLIDIN-1-YLSULFONYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Huang, X.

(2014) Bioorg Med Chem Lett 24: 3782-3785

Released	2015-05-06
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	35T

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4TTH \| pdb_00004tth	Download File View File

Crystal structure of a CDK6/Vcyclin complex with inhibitor bound

Piper, D.E., Walker, N., Wang, Z.

(2014) J Med Chem 57: 3430-3449

Released	2014-08-06
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Herpesvirus saimiri (strain 11) Homo sapiens
Macromolecule	Cyclin homolog (protein) Cyclin-dependent kinase 6 (protein)
Unique Ligands	24V

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4WT2 \| pdb_00004wt2	Download File View File

Co-crystal Structure of MDM2 in Complex with AM-7209

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 10499-10511

Released	2014-12-03
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	3UD, SO4

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5VTB \| pdb_00005vtb	Download File View File

Crystal structure of RBBP4 bound to BCL11a peptide

Meagher, J.L., Stuckey, J.A.

(2018) J Biological Chem 293: 2125-2136

Released	2017-12-27
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	B-cell lymphoma/leukemia 11A (protein) Histone-binding protein RBBP4 (protein)
Unique Ligands	GOL

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6UD2 \| pdb_00006ud2	Download File View File

co-crystal structure of compound 1 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4D

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6UDI \| pdb_00006udi	Download File View File

X-ray co-crystal structure of compound 20 with Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4S

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6UDT \| pdb_00006udt	Download File View File

X-ray co-crystal structure of compound 10 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4V

1 to 25 of 38 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1KAM | pdb_00001kam

1KAQ | pdb_00001kaq

4ERE | pdb_00004ere

4ERF | pdb_00004erf

4JV7 | pdb_00004jv7

4JV9 | pdb_00004jv9

4JVE | pdb_00004jve

4JVR | pdb_00004jvr

4JWR | pdb_00004jwr

4OAS | pdb_00004oas

4OBA | pdb_00004oba

4OCC | pdb_00004occ

4ODE | pdb_00004ode

4ODF | pdb_00004odf

4OGN | pdb_00004ogn

4OGT | pdb_00004ogt

4OGV | pdb_00004ogv

4QO4 | pdb_00004qo4

4QOC | pdb_00004qoc

4TTH | pdb_00004tth

4WT2 | pdb_00004wt2

5VTB | pdb_00005vtb

6UD2 | pdb_00006ud2

6UDI | pdb_00006udi

6UDT | pdb_00006udt