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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Meijer, L."

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Search Summary

This query matches 42 Structures.

Refinements

Structure Determination Methodology

experimental (42)

Scientific Name of Source Organism

	Homo sapiens (39)
	Bos taurus (6)
	Ovis aries (3)
	Saimiriine gammaherpesvirus 2 (1)

Taxonomy

	Eukaryota (42)
	Duplodnaviria (1)

Experimental Method

X-RAY DIFFRACTION (42)

Polymer Entity Type

Protein (42)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (5)
	2.0 - 2.5 (17)
	2.5 - 3.0 (15)
	3.0 - 3.5 (2)

Release Date

	1995 - 1999 (5)
	2000 - 2004 (6)
	2005 - 2009 (13)
	2010 - 2014 (6)
	2015 - 2019 (9)
	2020 - 2024 (3)

Enzyme Classification Name

Transferases (42)

Symmetry Type

	Asymmetric (41)
	Cyclic (1)

SCOP Classification

	Alpha and beta proteins (a+b) (32)
	Artifacts (11)
	All alpha proteins (12)
	Alpha and beta proteins (a/b) (3)

AllSelected

1 to 25 of 42 Structures

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1B38 \| pdb_00001b38	Download File View File

HUMAN CYCLIN-DEPENDENT KINASE 2

Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.

(1999) J Biological Chem 274: 8746-8756

Released	1998-12-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (CELL DIVISION PROTEIN KINASE 2) (protein)
Unique Ligands	ATP, MG

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1B39 \| pdb_00001b39	Download File View File

HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160

Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.

(1999) J Biological Chem 274: 8746-8756

Released	1998-12-23
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (CELL DIVISION PROTEIN KINASE 2) (protein)
Unique Ligands	ATP, MG

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1CKP \| pdb_00001ckp	Download File View File

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B

Gray, N.S., Thunnissen, A.M.W.H., Schultz, P.G., Kim, S.H.

(1998) Science 281: 533-538

Released	1999-01-13
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2) (protein)
Unique Ligands	EDO, PVB

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1DM2 \| pdb_00001dm2	Download File View File

HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE

Thunnissen, A.M., Kim, S.-H.

(2000) Chem Biol 7: 51-63

Released	2000-05-31
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 2 (protein)
Unique Ligands	EDO, HMD

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1E9H \| pdb_00001e9h	Download File View File

Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound

Davies, T.G., Tunnah, P., Noble, M.E.M., Endicott, J.A.

(2001) Structure 9: 389

Released	2001-10-11
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	CELL DIVISION PROTEIN KINASE 2 (protein) CYCLIN A3 (protein)
Unique Ligands	INR

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1HCK \| pdb_00001hck	Download File View File

HUMAN CYCLIN-DEPENDENT KINASE 2

Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.

(1996) J Med Chem 39: 4540-4546

Released	1996-12-07
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	HUMAN CYCLIN-DEPENDENT KINASE 2 (protein)
Unique Ligands	ATP, MG

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1HCL \| pdb_00001hcl	Download File View File

HUMAN CYCLIN-DEPENDENT KINASE 2

Schulze-Gahmen, U., De Bondt, H.L., Kim, S.-H.

(1996) J Med Chem 39: 4540-4546

Released	1996-12-07
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	HUMAN CYCLIN-DEPENDENT KINASE 2 (protein)

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1UNG \| pdb_00001ung	Download File View File

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	CELL DIVISION PROTEIN KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	ALH

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1UNH \| pdb_00001unh	Download File View File

Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	IXM

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1UNL \| pdb_00001unl	Download File View File

Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin.

Mapelli, M., Crovace, C., Massimiliano, L., Musacchio, A.

(2005) J Med Chem 48: 671

Released	2004-11-10
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 5 (protein) CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 (protein)
Unique Ligands	RRC

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1UV5 \| pdb_00001uv5	Download File View File

GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME

Dajani, R., Pearl, L.H., Roe, S.M.

(2003) Chem Biol 10: 1255

Released	2004-01-29
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	GLYCOGEN SYNTHASE KINASE-3 BETA (protein)
Unique Ligands	BRW, CL, CO, PO4

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1W0X \| pdb_00001w0x	Download File View File

Crystal structure of human CDK2 in complex with the inhibitor olomoucine.

Schulze-Gahmen, U., Meijer, L., Kim, S.-H.

(1995) Proteins 22: 378

Released	2005-01-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	CYCLIN-DEPENDENT KINASE 2 (protein)
Unique Ligands	OLO

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1XO2 \| pdb_00001xo2	Download File View File

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.

(2005) J Med Chem 48: 737-747

Released	2005-03-01
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens Saimiriine gammaherpesvirus 2
Macromolecule	Cell division protein kinase 6 (protein) Cyclin (protein)
Unique Ligands	FSE

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1YGJ \| pdb_00001ygj	Download File View File

Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives

Tang, L., Li, M.-H., Cao, P., Wang, F., Chang, W.-R., Bach, S., Reinhardt, J., Ferandin, Y., Koken, M., Galons, H., Wan, Y., Gray, N., Meijer, L., Jiang, T., Liang, D.-C.

(2005) J Biological Chem 280: 31220-31229

Released	2005-07-05
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Ovis aries
Macromolecule	Pyridoxal kinase (protein)
Unique Ligands	RMC

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1YGK \| pdb_00001ygk	Download File View File

Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives

Tang, L., Li, M.-H., Cao, P., Wang, F., Chang, W.-R., Bach, S., Reinhardt, J., Ferandin, Y., Koken, M., Galons, H., Wan, Y., Gray, N., Meijer, L., Jiang, T., Liang, D.-C.

(2005) J Biological Chem 280: 31220-31229

Released	2005-07-05
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Ovis aries
Macromolecule	Pyridoxal kinase (protein)
Unique Ligands	RRC

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1YHJ \| pdb_00001yhj	Download File View File

Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives

Tang, L., Li, M.-H., Cao, P., Wang, F., Chang, W.-R., Bach, S., Reinhardt, J., Ferandin, Y., Koken, M., Galons, H., Wan, Y., Gray, N., Meijer, L., Jiang, T., Liang, D.-C.

(2005) J Biological Chem 280: 31220-31229

Released	2005-07-05
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Ovis aries
Macromolecule	Pyridoxal Kinase (protein)
Unique Ligands	R6C

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2A4L \| pdb_00002a4l	Download File View File

Human cyclin-dependent kinase 2 in complex with roscovitine

De Azevedo Jr., W.F., Kim, S.H.

(1997) Eur J Biochem 243: 518-526

Released	2006-10-03
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Homo sapiens cyclin-dependent kinase 2 (protein)
Unique Ligands	RRC

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2EXM \| pdb_00002exm	Download File View File

Human CDK2 in complex with isopentenyladenine

Schulze-Gahmen, U.

(1995) Proteins 22: 378-391

Released	2005-12-27
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein)
Unique Ligands	ZIP

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3BHT \| pdb_00003bht	Download File View File

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3

Echalier, A., Bettayeb, K., Ferandin, Y., Lozach, O., Clement, M., Valette, A., Liger, F., Marquet, B., Morris, J.C., Endicott, J.A., Joseph, B., Meijer, L.

(2007) Cancer Res 67: 8325-8334

Released	2008-02-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	MFR, MG, SGM

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3BHU \| pdb_00003bhu	Download File View File

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5

Echalier, A., Bettayeb, K., Ferandin, Y., Lozach, O., Clement, M., Valette, A., Liger, F., Marquet, B., Morris, J.C., Endicott, J.A., Joseph, B., Meijer, L.

(2007) Cancer Res 67: 8325-8334

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	MG, MHR

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3BHV \| pdb_00003bhv	Download File View File

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B

Echalier, A., Bettayeb, K., Ferandin, Y., Lozach, O., Clement, M., Valette, A., Liger, F., Marquet, B., Morris, J.C., Endicott, J.A., Joseph, B., Meijer, L.

(2007) Cancer Res 67: 8325-8334

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	MG, SGM, VAR

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3DDP \| pdb_00003ddp	Download File View File

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8

Echalier, A., Endicott, J.A.

(2008) Oncogene 27: 5797-5807

Released	2008-07-22
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	RC8

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3DDQ \| pdb_00003ddq	Download File View File

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine

Echalier, A., Endicott, J.A.

(2008) Oncogene 27: 5797-5807

Released	2008-07-22
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	RRC, SGM

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3DOG \| pdb_00003dog	Download File View File

Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1

Echalier, A., Endicott, J.

(2008) Mol Cancer Ther 7: 2713-2724

Released	2008-09-30
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Bos taurus Homo sapiens
Macromolecule	Cell division protein kinase 2 (protein) Cyclin-A2 (protein)
Unique Ligands	NNN, SGM

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3LQ5 \| pdb_00003lq5	Download File View File

Structure of CDK9/CyclinT in complex with S-CR8

Hole, A.J., Endicott, J.A., Baumli, S.

(2010) Genes Cancer 1: 369-380

Released	2011-01-19
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Cell division protein kinase 9 (protein) Cyclin-T1 (protein)
Unique Ligands	SLQ

1 to 25 of 42 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1B38 | pdb_00001b38

1B39 | pdb_00001b39

1CKP | pdb_00001ckp

1DM2 | pdb_00001dm2

1E9H | pdb_00001e9h

1HCK | pdb_00001hck

1HCL | pdb_00001hcl

1UNG | pdb_00001ung

1UNH | pdb_00001unh

1UNL | pdb_00001unl

1UV5 | pdb_00001uv5

1W0X | pdb_00001w0x

1XO2 | pdb_00001xo2

1YGJ | pdb_00001ygj

1YGK | pdb_00001ygk

1YHJ | pdb_00001yhj

2A4L | pdb_00002a4l

2EXM | pdb_00002exm

3BHT | pdb_00003bht

3BHU | pdb_00003bhu

3BHV | pdb_00003bhv

3DDP | pdb_00003ddp

3DDQ | pdb_00003ddq

3DOG | pdb_00003dog

3LQ5 | pdb_00003lq5