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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Meleza, C."

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Search Summary

This query matches 11 Structures.

Refinements

Structure Determination Methodology

experimental (11)

Scientific Name of Source Organism

	Homo sapiens (10)
	Rattus norvegicus (1)

Taxonomy

Eukaryota (11)

Experimental Method

X-RAY DIFFRACTION (11)

Polymer Entity Type

Protein (11)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (6)
	2.0 - 2.5 (1)
	2.5 - 3.0 (3)

Release Date

	2010 - 2014 (1)
	2015 - 2019 (7)
	2020 - 2024 (3)

Enzyme Classification Name

	Transferases (3)
	Hydrolases (1)

Symmetry Type

	Asymmetric (10)
	Cyclic (6)

SCOP Classification

	Membrane and cell surface proteins and peptides (7)
	Alpha and beta proteins (a+b) (2)
	All alpha proteins (2)
	Alpha and beta proteins (a/b) (1)
	All beta proteins (1)
	Artifacts (1)

AllSelected

1 to 11 of 11 Structures

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3QK5 \| pdb_00003qk5	Download File View File

Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

Min, X., Walker, N.P.C., Wang, Z.

(2011) Bioorg Med Chem Lett 21: 2492-2496

Released	2011-04-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Rattus norvegicus
Macromolecule	Fatty-acid amide hydrolase 1 (protein)
Unique Ligands	EDO, GOL, QK5

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6UD2 \| pdb_00006ud2	Download File View File

co-crystal structure of compound 1 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4D

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6UDI \| pdb_00006udi	Download File View File

X-ray co-crystal structure of compound 20 with Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.94 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4S

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6UDT \| pdb_00006udt	Download File View File

X-ray co-crystal structure of compound 10 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4V

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6UDU \| pdb_00006udu	Download File View File

X-ray co-crystal structure of compound 8 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q4Y

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6UDV \| pdb_00006udv	Download File View File

X-ray co-crystal structure of compound 3 bound to human Mcl-1

Huang, X., Whittington, D.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-04
Method	X-RAY DIFFRACTION 1.35 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q51

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6UDX \| pdb_00006udx	Download File View File

X-ray co-crystal structure of compound 7 with Mcl-1

Huang, X.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q57

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6UDY \| pdb_00006udy	Download File View File

X-ray co-crystal structure of compound 5 with Mcl-1

Huang, X.

(2019) J Med Chem 62: 10258-10271

Released	2019-12-11
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	Q54

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6XRL \| pdb_00006xrl	Download File View File

Crystal structure of human PI3K-gamma in complex with inhibitor IPI-549

Walker, N.P., Jeffrey, J.L.

(2020) J Med Chem 63: 11235-11257

Released	2020-09-16
Method	X-RAY DIFFRACTION 2.99 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	SO4, V7Y

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6XRM \| pdb_00006xrm	Download File View File

Crystal structure of human PI3K-gamma in complex with Compound 4

Walker, N.P., Jeffrey, J.L.

(2020) J Med Chem 63: 11235-11257

Released	2020-09-16
Method	X-RAY DIFFRACTION 2.88 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	SO4, V81

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6XRN \| pdb_00006xrn	Download File View File

Crystal structure of human PI3K-gamma in complex with Compound 17

Walker, N.P., Jeffrey, J.L.

(2022) J Med Chem 65: 1418-1444

Released	2021-11-03
Method	X-RAY DIFFRACTION 2.96 Å
Organisms	Homo sapiens
Macromolecule	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (protein)
Unique Ligands	V84

1 to 11 of 11 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3QK5 | pdb_00003qk5

Crystal structure of fatty acid amide hydrolase with small molecule inhibitor

6UD2 | pdb_00006ud2

co-crystal structure of compound 1 bound to human Mcl-1

6UDI | pdb_00006udi

X-ray co-crystal structure of compound 20 with Mcl-1

6UDT | pdb_00006udt

X-ray co-crystal structure of compound 10 bound to human Mcl-1

6UDU | pdb_00006udu

X-ray co-crystal structure of compound 8 bound to human Mcl-1

6UDV | pdb_00006udv

X-ray co-crystal structure of compound 3 bound to human Mcl-1

6UDX | pdb_00006udx

X-ray co-crystal structure of compound 7 with Mcl-1

6UDY | pdb_00006udy

X-ray co-crystal structure of compound 5 with Mcl-1

6XRL | pdb_00006xrl

Crystal structure of human PI3K-gamma in complex with inhibitor IPI-549

6XRM | pdb_00006xrm

Crystal structure of human PI3K-gamma in complex with Compound 4

6XRN | pdb_00006xrn

Crystal structure of human PI3K-gamma in complex with Compound 17

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3QK5 | pdb_00003qk5

6UD2 | pdb_00006ud2

6UDI | pdb_00006udi

6UDT | pdb_00006udt

6UDU | pdb_00006udu

6UDV | pdb_00006udv

6UDX | pdb_00006udx

6UDY | pdb_00006udy

6XRL | pdb_00006xrl

6XRM | pdb_00006xrm

6XRN | pdb_00006xrn