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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Mochalkin, I."

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Search Summary

This query matches 56 Structures.

Refinements

Structure Determination Methodology

experimental (56)

Scientific Name of Source Organism

	Homo sapiens (29)
	Escherichia coli (13)
	Haemophilus influenzae (8)
	Hirudo medicinalis (3)
	Gallus gallus (2)
	Pseudomonas aeruginosa (2)
	Pseudomonas aeruginosa PAO1 (1)
	Staphylococcus aureus (1)
	Streptococcus pyogenes (1)

Taxonomy

	Eukaryota (31)
	Bacteria (26)
	Eukaryota (eukaryotes) (1)

Experimental Method

X-RAY DIFFRACTION (56)

Polymer Entity Type

Protein (56)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (14)
	2.0 - 2.5 (24)
	2.5 - 3.0 (11)
	3.0 - 3.5 (1)
	> 4.5 (1)

Release Date

	1995 - 1999 (6)
	2000 - 2004 (8)
	2005 - 2009 (31)
	2015 - 2019 (8)
	2020 - 2024 (2)
	2025 - 2029 (1)

Enzyme Classification Name

	Transferases (19)
	Hydrolases (19)
	Ligases (16)

Symmetry Type

	Asymmetric (41)
	Cyclic (16)

SCOP Classification

	All beta proteins (37)
	Alpha and beta proteins (a+b) (25)
	Alpha and beta proteins (a/b) (24)
	Small proteins (7)
	Coiled coil proteins (1)
	Low resolution protein structures (1)
	Artifacts (2)

AllSelected

1 to 25 of 56 Structures

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1C4U \| pdb_00001c4u	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	PROTEIN (HIRUGEN) (protein) thrombin (protein)
Unique Ligands	IH1, NA

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1C4V \| pdb_00001c4v	Download File View File

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-09-27
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH2, NA

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1C4Y \| pdb_00001c4y	Download File View File

SELECTIVE NON-ELECTROPHILIC THROMBIN INHIBITORS

Krishnan, R., Mochalkin, I., Arni, R.K., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-09
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN:LONG CHAIN (protein) THROMBIN:SHORT CHAIN (protein)
Unique Ligands	IH3

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1D6W \| pdb_00001d6w	Download File View File

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

Mochalkin, I., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-25
Method	X-RAY DIFFRACTION 2 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	DECAPEPTIDE INHIBITOR (protein) THROMBIN (protein)
Unique Ligands	00R, NA

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1D9I \| pdb_00001d9i	Download File View File

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTOPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

Krishnan, R., Mochalkin, I., Arni, R., Tulinsky, A.

(2000) Acta Crystallogr D Biol Crystallogr 56: 294-303

Released	2000-10-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Hirudo medicinalis Homo sapiens
Macromolecule	HIRUGEN (protein) THROMBIN (protein)
Unique Ligands	00P, NA

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1EI3 \| pdb_00001ei3	Download File View File

CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN

Yang, Z., Mochalkin, I., Veerapandian, L., Riley, M., Doolittle, R.F.

(2000) Proc Natl Acad Sci U S A 97: 3907-3912

Released	2000-05-10
Method	X-RAY DIFFRACTION 5.5 Å
Organisms	Gallus gallus
Macromolecule	FIBRINOGEN (protein)

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1I5K \| pdb_00001i5k	Download File View File

STRUCTURE AND BINDING DETERMINANTS OF THE RECOMBINANT KRINGLE-2 DOMAIN OF HUMAN PLASMINOGEN TO AN INTERNAL PEPTIDE FROM A GROUP A STREPTOCOCCAL SURFACE PROTEIN

Rios-Steiner, J.L., Schenone, M., Mochalkin, I., Tulinsky, A., Castellino, F.J.

(2001) J Mol Biology 308: 705-719

Released	2001-08-01
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Homo sapiens Streptococcus pyogenes
Macromolecule	M PROTEIN (protein) PLASMINOGEN (protein)

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1KIV \| pdb_00001kiv	Download File View File

RECOMBINANT KRINGLE IV-10/M66 VARIANT OF HUMAN APOLIPOPROTEIN(A)

Mochalkin, I., Tulinsky, A., Scanu, A.

(1999) Biochemistry 38: 1990-1998

Released	1999-05-18
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	APOLIPOPROTEIN A (protein)

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1M1J \| pdb_00001m1j	Download File View File

Crystal structure of native chicken fibrinogen with two different bound ligands

Yang, Z., Kollman, J.M., Pandi, L., Doolittle, R.F.

(2001) Biochemistry 40: 12515-12523

Released	2002-06-26
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Gallus gallus
Macromolecule	Fibrinogen alpha subunit (protein) Fibrinogen beta chain (protein) Fibrinogen gamma chain (protein) GLY-HIS-ARG-PRO peptide (protein) GLY-PRO-ARG-PRO peptide (protein)
Unique Ligands	CA, NAG, NDG

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2C00 \| pdb_00002c00	Download File View File

Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa in apo form

Mochalkin, I.

(2008) Protein Sci 17: 1706

Released	2008-09-09
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Pseudomonas aeruginosa
Macromolecule	BIOTIN CARBOXYLASE (protein)
Unique Ligands	SO4

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2I4Q \| pdb_00002i4q	Download File View File

Human renin/PF02342674 complex

Holsworth, D.D., Jalaie, M., Zhang, E., Mcconnell, P., Mochalkin, I., Finzel, B.C.

(2007) Bioorg Med Chem 15: 5912-5949

Released	2006-10-24
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Renin (protein)
Unique Ligands	UA4

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2IKO \| pdb_00002iko	Download File View File

Crystal Structure of Human Renin Complexed with Inhibitor

Mochalkin, I.

(2007) Anal Biochem 360: 30-40

Released	2006-11-14
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Renin (protein)
Unique Ligands	7IG

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2IKU \| pdb_00002iku	Download File View File

Crystal Structure of Human Renin Complexed with Inhibitors

Mochalkin, I.

(2007) Anal Biochem 360: 30-40

Released	2006-12-05
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Renin (protein)
Unique Ligands	LIY

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2IL2 \| pdb_00002il2	Download File View File

Crystal Structure of Human Renin Complexed with Inhibitor

Mochalkin, I.

(2007) Anal Biochem 360: 30-40

Released	2006-12-05
Method	X-RAY DIFFRACTION 2.24 Å
Organisms	Homo sapiens
Macromolecule	Renin (protein)
Unique Ligands	CIT, LIX

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2J9G \| pdb_00002j9g	Download File View File

Crystal structure of Biotin carboxylase from E. coli in complex with AMPPNP and ADP

Mochalkin, I.

(2008) Protein Sci 17: 1706

Released	2008-09-09
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Escherichia coli
Macromolecule	BIOTIN CARBOXYLASE (protein)
Unique Ligands	ADP, ANP, MG, SO4

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2V0H \| pdb_00002v0h	Download File View File

Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)

Mochalkin, I., Lightle, S., Ohren, J.F., Chirgadze, N.Y.

(2007) Protein Sci 16: 2657

Released	2008-01-15
Method	X-RAY DIFFRACTION 1.79 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	CO, PEG, SO4

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2V0I \| pdb_00002v0i	Download File View File

Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)

Mochalkin, I., Lightle, S., Ohren, J.F., Chirgadze, N.Y.

(2007) Protein Sci 16: 2657

Released	2008-01-15
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	PEG, PG4, SO4, UD1

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2V0J \| pdb_00002v0j	Download File View File

Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)

Mochalkin, I., Lightle, S., Ohren, J.F., Chirgadze, N.Y.

(2007) Protein Sci 16: 2657

Released	2008-01-15
Method	X-RAY DIFFRACTION 2 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	H2U, MG, PG4, PGE, SO4

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2V0K \| pdb_00002v0k	Download File View File

Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)

Mochalkin, I., Lightle, S., Ohren, J.F., Chirgadze, N.Y.

(2007) Protein Sci 16: 2657

Released	2008-01-15
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	PG4, PGE, SO4, UDP

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2V0L \| pdb_00002v0l	Download File View File

Characterization of Substrate Binding and Catalysis of the Potential Antibacterial Target N-acetylglucosamine-1-phosphate Uridyltransferase (GlmU)

Mochalkin, I., Lightle, S., Ohren, J.F., Chirgadze, N.Y.

(2007) Protein Sci 16: 2657

Released	2008-01-15
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	PG4, PGE, SO4, URI

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2V58 \| pdb_00002v58	Download File View File

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 1

Mochalkin, I., Miller, J.R.

(2009) Proc Natl Acad Sci U S A 106: 1737

Released	2009-01-13
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Escherichia coli
Macromolecule	BIOTIN CARBOXYLASE (protein)
Unique Ligands	CL, LZJ

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2V59 \| pdb_00002v59	Download File View File

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2

Mochalkin, I., Miller, J.R.

(2009) Proc Natl Acad Sci U S A 106: 1737

Released	2009-01-13
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli
Macromolecule	BIOTIN CARBOXYLASE (protein)
Unique Ligands	LZK

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2V5A \| pdb_00002v5a	Download File View File

CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 3

Mochalkin, I., Miller, J.R.

(2009) Proc Natl Acad Sci U S A 106: 1737

Released	2009-01-13
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Escherichia coli
Macromolecule	BIOTIN CARBOXYLASE (protein)
Unique Ligands	CL, LZL

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2VD4 \| pdb_00002vd4	Download File View File

Structure of small-molecule inhibitor of Glmu from Haemophilus influenzae reveals an allosteric binding site

Mochalkin, I., Lightle, S., McDowell, L.

(2008) Protein Sci 17: 577

Released	2008-01-15
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Haemophilus influenzae
Macromolecule	BIFUNCTIONAL PROTEIN GLMU (protein)
Unique Ligands	MG, P21, PG4, PGE, SO4

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2VES \| pdb_00002ves	Download File View File

Crystal Structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

Mochalkin, I., Knafels, J.D.

(2008) Protein Sci 17: 450-457

Released	2008-01-15
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Pseudomonas aeruginosa PAO1
Macromolecule	UDP-3-O-acyl-N-acetylglucosamine deacetylase (protein)
Unique Ligands	GVR, SO4, ZN

1 to 25 of 56 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1C4U | pdb_00001c4u

1C4V | pdb_00001c4v

1C4Y | pdb_00001c4y

1D6W | pdb_00001d6w

1D9I | pdb_00001d9i

1EI3 | pdb_00001ei3

1I5K | pdb_00001i5k

1KIV | pdb_00001kiv

1M1J | pdb_00001m1j

2C00 | pdb_00002c00

2I4Q | pdb_00002i4q

2IKO | pdb_00002iko

2IKU | pdb_00002iku

2IL2 | pdb_00002il2

2J9G | pdb_00002j9g

2V0H | pdb_00002v0h

2V0I | pdb_00002v0i

2V0J | pdb_00002v0j

2V0K | pdb_00002v0k

2V0L | pdb_00002v0l

2V58 | pdb_00002v58

2V59 | pdb_00002v59

2V5A | pdb_00002v5a

2VD4 | pdb_00002vd4

2VES | pdb_00002ves