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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Rex, K."

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Search Summary

This query matches 26 Structures.

Refinements

Structure Determination Methodology

experimental (26)

Scientific Name of Source Organism

Homo sapiens (26)

Taxonomy

Eukaryota (26)

Experimental Method

X-RAY DIFFRACTION (26)

Polymer Entity Type

Protein (26)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (9)
	2.0 - 2.5 (13)
	2.5 - 3.0 (3)

Release Date

	2005 - 2009 (6)
	2010 - 2014 (8)
	2015 - 2019 (10)
	2025 - 2029 (2)

Enzyme Classification Name

	Transferases (21)
	Hydrolases (5)

Symmetry Type

	Asymmetric (26)
	Cyclic (4)

SCOP Classification

	Alpha and beta proteins (a+b) (20)
	Alpha and beta proteins (a/b) (3)
	Artifacts (2)

AllSelected

1 to 25 of 26 Structures

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2RFN \| pdb_00002rfn	Download File View File

x-ray structure of c-Met with inhibitor.

Bellon, S.F., Kaplan-Lefko, P., Yang, Y., Zhang, Y., Moriguchi, J., Dussault, I.

(2008) J Biological Chem 283: 2675-2683

Released	2007-11-06
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	AM7

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2RFS \| pdb_00002rfs	Download File View File

X-ray structure of SU11274 bound to c-Met

Bellon, S.F., Kaplan-Lefko, P., Yang, Y., Zhang, Y., Moriguchi, J., Dussault, I.

(2008) J Biological Chem 283: 2675-2683

Released	2007-11-06
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	AM8

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3CCN \| pdb_00003ccn	Download File View File

X-ray structure of c-Met with triazolopyridazine inhibitor.

Abrecht, B.K., Harmange, J.-C., Bauer, D., Dussault, I., long, A., Bellon, S.F.

(2008) J Med Chem 51: 2879-2882

Released	2008-04-29
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	LKG

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3CD8 \| pdb_00003cd8	Download File View File

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Bellon, S.F., Albrecht, B.K., Harmange, J.-C., Bauer, D., Choquette, D., Dussault, I.

(2008) J Med Chem 51: 2879-2882

Released	2008-04-29
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	L5G

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3EFJ \| pdb_00003efj	Download File View File

Structure of c-Met with pyrimidone inhibitor 7

D'Angelo, N., Bellon, S., Whittington, D.

(2008) J Med Chem 51: 5766-5779

Released	2008-10-07
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	MT3

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3EFK \| pdb_00003efk	Download File View File

Structure of c-Met with pyrimidone inhibitor 50

Bellon, S.F., D'Angelo, N., Whittington, D., Dussault, I.

(2008) J Med Chem 51: 5766-5779

Released	2008-10-07
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	MT4

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3I5N \| pdb_00003i5n	Download File View File

Crystal structure of c-Met with triazolopyridazine inhibitor 13

Bellon, S.F., Whittington, D.A., Long, A.M., Boezio, A.A.

(2009) Bioorg Med Chem Lett 19: 6307-6312

Released	2010-01-12
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	B2D

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3U6H \| pdb_00003u6h	Download File View File

Crystal structure of c-Met in complex with pyrazolone inhibitor 26

Bellon, S.F., Whittington, D.A., Long, A.L.

(2012) J Med Chem 55: 1858-1867

Released	2012-02-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	03X

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3U6I \| pdb_00003u6i	Download File View File

Crystal structure of c-Met in complex with pyrazolone inhibitor 58a

Bellon, S.F., Whittington, D.A., Long, A.L.

(2012) J Med Chem 55: 1858-1867

Released	2012-02-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	044

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3U6J \| pdb_00003u6j	Download File View File

Crystal structure of the VEGFR2 kinase domain in complex with a pyrazolone inhibitor

Whittington, D.A., Long, A., Rose, P., Gu, Y., Zhao, H.

(2012) J Med Chem 55: 1858-1867

Released	2012-02-22
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Vascular endothelial growth factor receptor 2 (protein)
Unique Ligands	03X

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4DEG \| pdb_00004deg	Download File View File

Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2

Whittington, D.A., Bellon, S.F., Long, A.M.

(2012) Bioorg Med Chem Lett 22: 4089-4093

Released	2012-05-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	0JJ

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4DEH \| pdb_00004deh	Download File View File

Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3

Whittington, D.A., Bellon, S.F., Long, A.M.

(2012) Bioorg Med Chem Lett 22: 4089-4093

Released	2012-05-30
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	0JK

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4DEI \| pdb_00004dei	Download File View File

Crystal structure of c-Met in complex with triazolopyridinone inhibitor 24

Whittington, D.A., Long, A.M.

(2012) Bioorg Med Chem Lett 22: 4089-4093

Released	2012-05-30
Method	X-RAY DIFFRACTION 2.05 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	0JL

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4L02 \| pdb_00004l02	Download File View File

Crystal Structure of SphK1 with inhibitor

Min, X., Walker, N., Wang, Z.

(2013) Bioorg Med Chem Lett 23: 4608-4616

Released	2013-07-24
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Homo sapiens
Macromolecule	Sphingosine kinase 1 (protein)
Unique Ligands	1V2

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4XMO \| pdb_00004xmo	Download File View File

Crystal structure of c-Met in complex with (R)-5-(8-fluoro-3-(1-fluoro-1-(3-methoxyquinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole

Whittington, D.A., Long, A.M.

(2015) J Med Chem 58: 2417-2430

Released	2015-03-11
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	46G

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4XYF \| pdb_00004xyf	Download File View File

Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole

Whittington, D.A., Long, A.M.

(2015) J Med Chem 58: 2417-2430

Released	2015-03-11
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	44X

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5EOL \| pdb_00005eol	Download File View File

Crystal structure of human Pim-1 kinase in complex with a macrocyclic quinoxaline-pyrrolodihydropiperidinone inhibitor

Mohr, C.

(2016) ACS Med Chem Lett 7: 408-412

Released	2016-05-04
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	5QO, GOL

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5EYC \| pdb_00005eyc	Download File View File

Crystal structure of c-Met in complex with naphthyridinone inhibitor 5

Whittington, D.A., Long, A.M.

(2016) J Med Chem 59: 2328-2342

Released	2016-02-10
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	5SZ

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5EYD \| pdb_00005eyd	Download File View File

Crystal structure of c-Met in complex with AMG 337

Whittington, D.A., Long, A.M.

(2016) J Med Chem 59: 2328-2342

Released	2016-02-10
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Homo sapiens
Macromolecule	Hepatocyte growth factor receptor (protein)
Unique Ligands	5T1

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5IPJ \| pdb_00005ipj	Download File View File

Crystal structure of human Pim-1 kinase in complex with a quinazolinone-pyrrolopyrrolone inhibitor.

Mohr, C.

(2016) J Med Chem 59: 6407-6430

Released	2016-06-22
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	6CD, GOL

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6MT0 \| pdb_00006mt0	Download File View File

Crystal structure of human Pim-1 kinase in complex with a quinazolinone-pyrrolodihydropyrrolone inhibitor

Mohr, C.

(2019) J Med Chem 62: 1523-1540

Released	2019-01-16
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	GOL, JYG