RCSB PDB: Search

4B6E \| pdb_00004b6e	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.46 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	10L, SO4

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4B6F \| pdb_00004b6f	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.89 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	20L, SO4

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4B71 \| pdb_00004b71	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	DJL

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4B73 \| pdb_00004b73	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	4VA

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4B74 \| pdb_00004b74	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.18 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	1LH

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4B75 \| pdb_00004b75	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.53 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	4VA

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4B76 \| pdb_00004b76	Download File View File

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function

Saalau-Bethell, S.M., Woodhead, A.J., Chessari, G., Carr, M.G., Coyle, J., Graham, B., Hiscock, S.D., Murray, C.W., Pathuri, P., Rich, S.J., Richardson, C.J., Williams, P.A., Jhoti, H.

(2012) Nat Chem Biol 8: 920

Released	2012-10-03
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Hepatitis C virus (isolate BK)
Macromolecule	NON-STRUCTURAL PROTEIN 4A, SERINE PROTEASE NS3 (protein)
Unique Ligands	PW1

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4OYA \| pdb_00004oya	Download File View File

Human solAC Complexed with (4-Aminofurazan-3-yl)-[3-(1H-benzoimidazol-2-ylmethoxy)phenyl]methanone

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1VE, GOL

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4OYB \| pdb_00004oyb	Download File View File

Crystal Structure Analysis of the solAC

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1VJ, GOL

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4OYI \| pdb_00004oyi	Download File View File

Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1VK, GOL

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4OYM \| pdb_00004oym	Download File View File

Human solAC Complexed with (4-Amino-furazan-3-yl)-(3-methoxy-phenyl)-methanone

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1ZC, GOL

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4OYO \| pdb_00004oyo	Download File View File

Human solAC Complexed with 4-(2-Chlorophenyl)-3-methyl-1H-pyrazole

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.75 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1WC, GOL

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4OYP \| pdb_00004oyp	Download File View File

Human solAC Complexed with 1-Benzofuran-2-carboxylic acid

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.28 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	BZ2, CL

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4OYW \| pdb_00004oyw	Download File View File

Crystal Structure of Human Soluble Adenylate Cyclase

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	CL, GOL

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4OYX \| pdb_00004oyx	Download File View File

Human solAC Complexed with AMPCPP

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	APC, CA, CL

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4OYZ \| pdb_00004oyz	Download File View File

Human solAC Complexed with Bicarbonate

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	BCT, GOL

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4OZ2 \| pdb_00004oz2	Download File View File

Human solAC Complexed with 4-(4-Fluorophenyl)-3-methyl-1H-pyrazole

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1Z6, CL, GOL

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4OZ3 \| pdb_00004oz3	Download File View File

Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole

Vinkovic, M.

(2014) ChemMedChem 9: 823-832

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Adenylate cyclase type 10 (protein)
Unique Ligands	1Z8, GOL

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5C0K \| pdb_00005c0k	Download File View File

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 3

Chessari, G., Buck, I.M., Day, J.E.H., Day, P.J., Iqbal, A., Johnson, C.N., Lewis, E.J., Martins, V., Miller, D., Reader, M., Rees, D.C., Rich, S.J., Tamanini, E., Vitorino, M., Ward, G.A., Williams, P.A., Williams, G., Wilsher, N.E., Woolford, A.J.-A.

(2015) J Med Chem 58: 6574-6588

Released	2015-08-12
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase XIAP (protein)
Unique Ligands	4WK, EDO, ZN