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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Saiki, A.Y."

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Search Summary

This query matches 27 Structures.

Refinements

Structure Determination Methodology

experimental (27)

Scientific Name of Source Organism

	Homo sapiens (26)
	Streptococcus pneumoniae (1)

Taxonomy

	Eukaryota (26)
	Bacteria (1)

Experimental Method

	X-RAY DIFFRACTION (26)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (27)

Refinement Resolution (Å)

	1.0 - 1.5 (3)
	1.5 - 2.0 (13)
	2.0 - 2.5 (9)
	2.5 - 3.0 (1)

Release Date

	2000 - 2004 (1)
	2010 - 2014 (17)
	2015 - 2019 (7)
	2025 - 2029 (2)

Enzyme Classification Name

	Transferases (18)
	Ligases (17)
	Hydrolases (9)

Symmetry Type

Asymmetric (27)

SCOP Classification

	All alpha proteins (17)
	Alpha and beta proteins (a/b) (8)
	Artifacts (4)

AllSelected

1 to 25 of 27 Structures

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1Q3T \| pdb_00001q3t	Download File View File

Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae

Yu, L., Mack, J., Hajduk, P.J., Kakavas, S.J., Saiki, A.Y., Lerner, C.G., Olejniczak, E.T.

(2003) Protein Sci 12: 2613-2621

Released	2004-08-03
Method	SOLUTION NMR
Organisms	Streptococcus pneumoniae
Macromolecule	Cytidylate kinase (protein)

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4ERE \| pdb_00004ere	Download File View File

crystal structure of MDM2 (17-111) in complex with compound 23

Huang, X.

(2012) J Med Chem 55: 4936-4954

Released	2012-05-23
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	0R2, SO4

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4ERF \| pdb_00004erf	Download File View File

crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)

Huang, X.

(2012) J Med Chem 55: 4936-4954

Released	2012-05-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	0R3

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4JV7 \| pdb_00004jv7	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MN, SO4

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4JV9 \| pdb_00004jv9	Download File View File

Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MO, SO4

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4JVE \| pdb_00004jve	Download File View File

Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MQ

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4JVR \| pdb_00004jvr	Download File View File

Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MT

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4JWR \| pdb_00004jwr	Download File View File

Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid

Shaffer, P.L.

(2013) J Med Chem 56: 4053-4070

Released	2013-05-01
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	1MY

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4OAS \| pdb_00004oas	Download File View File

co-crystal structure of MDM2 (17-111) in complex with compound 25

Huang, X.

(2014) J Med Chem 57: 1454-1472

Released	2014-02-19
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2SW, SO4

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4OBA \| pdb_00004oba	Download File View File

Co-crystal structure of MDM2 with Inhibitor Compound 4

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2472-2488

Released	2014-03-19
Method	X-RAY DIFFRACTION 1.602 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2TW

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4OCC \| pdb_00004occ	Download File View File

co-crystal structure of MDM2(17-111) in complex with compound 48

Huang, X.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2TZ

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4ODE \| pdb_00004ode	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 4

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U0, SO4

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4ODF \| pdb_00004odf	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 47

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.2006 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U1

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4OGN \| pdb_00004ogn	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 3

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.377 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U5, SO4

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4OGT \| pdb_00004ogt	Download File View File

Co-Crystal Structure of MDM2 with Inhbitor Compound 46

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 1.5361 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U6, SO4

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4OGV \| pdb_00004ogv	Download File View File

Co-Crystal Structure of MDM2 with Inhibitor Compound 49

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 2963-2988

Released	2014-04-02
Method	X-RAY DIFFRACTION 2.197 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	2U7

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4QO4 \| pdb_00004qo4	Download File View File

co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID

Huang, X.

(2014) ACS Med Chem Lett 5: 894-899

Released	2014-07-16
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	35S

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4WT2 \| pdb_00004wt2	Download File View File

Co-crystal Structure of MDM2 in Complex with AM-7209

Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.

(2014) J Med Chem 57: 10499-10511

Released	2014-12-03
Method	X-RAY DIFFRACTION 1.42 Å
Organisms	Homo sapiens
Macromolecule	E3 ubiquitin-protein ligase Mdm2 (protein)
Unique Ligands	3UD, SO4

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6OIM \| pdb_00006oim	Download File View File

Crystal Structure of human KRAS G12C covalently bound to AMG 510

Mohr, C.

(2019) Nature 575: 217-223

Released	2019-11-06
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	GDP, MG, MOV

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6P8W \| pdb_00006p8w	Download File View File

Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.

Mohr, C.

(2019) ACS Med Chem Lett 10: 1302-1308

Released	2019-08-28
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	CA, GDP, O67

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6P8X \| pdb_00006p8x	Download File View File

Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.

Mohr, C.

(2019) ACS Med Chem Lett 10: 1302-1308

Released	2019-08-28
Method	X-RAY DIFFRACTION 2.11 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	CA, GDP, O5V

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6P8Y \| pdb_00006p8y	Download File View File

Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.

Mohr, C.

(2019) ACS Med Chem Lett 10: 1302-1308

Released	2019-08-28
Method	X-RAY DIFFRACTION 2.31 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	GDP, MG, O5Y

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6P8Z \| pdb_00006p8z	Download File View File

Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor

Mohr, C.

(2019) ACS Med Chem Lett 10: 1302-1308

Released	2019-08-28
Method	X-RAY DIFFRACTION 1.65 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	CA, GDP, O5S

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6PGO \| pdb_00006pgo	Download File View File

Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor

Mohr, C.

(2020) J Med Chem 63: 52-65

Released	2019-12-25
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	GDP, MG, OJ1

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6PGP \| pdb_00006pgp	Download File View File

Crystal structure of human KRAS G12C covalently bound to a quinazolinone inhibitor

Mohr, C., Whittington, D.A.

(2020) J Med Chem 63: 52-65

Released	2019-12-25
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	GTPase KRas (protein)
Unique Ligands	CA, GDP, OHY

1 to 25 of 27 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1Q3T | pdb_00001q3t

4ERE | pdb_00004ere

4ERF | pdb_00004erf

4JV7 | pdb_00004jv7

4JV9 | pdb_00004jv9

4JVE | pdb_00004jve

4JVR | pdb_00004jvr

4JWR | pdb_00004jwr

4OAS | pdb_00004oas

4OBA | pdb_00004oba

4OCC | pdb_00004occ

4ODE | pdb_00004ode

4ODF | pdb_00004odf

4OGN | pdb_00004ogn

4OGT | pdb_00004ogt

4OGV | pdb_00004ogv

4QO4 | pdb_00004qo4

4WT2 | pdb_00004wt2

6OIM | pdb_00006oim

6P8W | pdb_00006p8w

6P8X | pdb_00006p8x

6P8Y | pdb_00006p8y

6P8Z | pdb_00006p8z

6PGO | pdb_00006pgo

6PGP | pdb_00006pgp