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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Citation Author = "Whittingham, J.L."

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Search Summary

This query matches 45 Structures.

Refinements

Structure Determination Methodology

experimental (45)

Scientific Name of Source Organism

	Homo sapiens (14)
	Plasmodium falciparum 3D7 (13)
	Sus scrofa (4)
	Clostridioides difficile 630 (2)
	Nostoc sp. PCC 7120 = FACHB-418 (2)
	Prescottella equi 103S (2)
	Streptococcus agalactiae (2)
	synthetic construct (2)
	Bos taurus (1)
	Escherichia coli (1)

More...

Taxonomy

	Eukaryota (29)
	Bacteria (14)
	Eukaryota (eukaryotes) (3)
	other sequences (2)

Experimental Method

X-RAY DIFFRACTION (45)

Polymer Entity Type

Protein (45)

Refinement Resolution (Å)

	1.0 - 1.5 (7)
	1.5 - 2.0 (22)
	2.0 - 2.5 (13)
	2.5 - 3.0 (3)

Release Date

	1995 - 1999 (12)
	2000 - 2004 (5)
	2005 - 2009 (7)
	2010 - 2014 (13)
	2015 - 2019 (6)
	2020 - 2024 (2)

Enzyme Classification Name

	Transferases (7)
	Hydrolases (10)
	Oxidoreductases (2)

Symmetry Type

	Asymmetric (22)
	Cyclic (17)
	Dihedral (19)

SCOP Classification

	Small proteins (15)
	Alpha and beta proteins (a/b) (11)
	All beta proteins (4)
	Artifacts (2)

AllSelected

1 to 25 of 45 Structures

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1G7A \| pdb_00001g7a	Download File View File

1.2 A structure of T3R3 human insulin at 100 K

Smith, G.D., Pangborn, W.A., Blessing, R.H.

(2001) Acta Crystallogr D Biol Crystallogr 57: 1091-1100

Released	2001-08-03
Method	X-RAY DIFFRACTION 1.2 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A-CHAIN (protein) INSULIN B-CHAIN (protein)
Unique Ligands	ACN, CL, GOL, ZN

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1G7B \| pdb_00001g7b	Download File View File

1.3 A STRUCTURE OF T3R3 HUMAN INSULIN AT 100 K

Smith, G.D., Pangborn, W.A., Blessing, R.H.

(2001) Acta Crystallogr D Biol Crystallogr 57: 1091-1100

Released	2001-08-03
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A-CHAIN (protein) INSULIN B-CHAIN (protein)
Unique Ligands	ACN, CL, GOL, ZN

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1GUJ \| pdb_00001guj	Download File View File

Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation.

Whittingham, J.L., Scott, D.J., Chance, K., Wilson, A., Finch, J., Brange, J., Dodson, G.G.

(2002) J Mol Biology 318: 479

Released	2002-03-08
Method	X-RAY DIFFRACTION 1.62 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	SO4

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1MPJ \| pdb_00001mpj	Download File View File

X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL

Whittingham, J.L., Dodson, E.J., Moody, P.C.E., Dodson, G.G.

(1995) Biochemistry 34: 15553-15563

Released	1996-01-29
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Sus scrofa
Macromolecule	PHENOL INSULIN (protein)
Unique Ligands	CL, IPH, ZN

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1O8U \| pdb_00001o8u	Download File View File

The 2 Angstrom Structure of 6-Oxo Camphor Hydrolase: New Structural Diversity in the Crotonase Superfamily

Grogan, G., Whittingham, J.L., Turkenburg, J.P., Verma, C.S., Walsh, M.A.

(2003) J Biological Chem 278: 1744

Released	2003-01-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Rhodococcus erythropolis
Macromolecule	6-OXO CAMPHOR HYDROLASE (protein)
Unique Ligands	NA

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1PID \| pdb_00001pid	Download File View File

BOVINE DESPENTAPEPTIDE INSULIN

Holden, P.H., Papiz, M., Dodson, G.G.

(1997) Proteins 27: 507-516

Released	1996-12-07
Method	X-RAY DIFFRACTION 1.3 Å
Organisms	Bos taurus
Macromolecule	DESPENTAPEPTIDE INSULIN (protein)

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1QIY \| pdb_00001qiy	Download File View File

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL

Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.

(1999) Biochemistry 38: 12041

Released	1999-06-22
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A CHAIN (protein) INSULIN B CHAIN (protein)
Unique Ligands	CL, IPH, ZN

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1QIZ \| pdb_00001qiz	Download File View File

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH RESORCINOL

Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.

(1999) Biochemistry 38: 12041

Released	1999-06-22
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A CHAIN (protein) INSULIN B CHAIN (protein)
Unique Ligands	CL, RCO, ZN

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1QJ0 \| pdb_00001qj0	Download File View File

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR

Tang, L., Whittingham, J.L., Verma, C.S., Caves, L.S.D., Dodson, G.G.

(1999) Biochemistry 38: 12041

Released	1999-06-22
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A CHAIN (protein) INSULIN B CHAIN (protein)
Unique Ligands	CL, ZN

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1RWE \| pdb_00001rwe	Download File View File

Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues

Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.

(2004) Biochemistry 43: 16119-16133

Released	2005-02-15
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Insulin (protein) insulin (protein)
Unique Ligands	CL, IPH, ZN

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1SZO \| pdb_00001szo	Download File View File

Crystal Structure Analysis of the 6-Oxo Camphor Hydrolase His122Ala Mutant Bound to Its Natural Product (2S,4S)-alpha-Campholinic Acid

Leonard, P.M., Grogan, G.

(2004) J Biological Chem 279: 31312-31317

Released	2004-06-29
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Rhodococcus sp. NCIMB 9784
Macromolecule	6-oxocamphor hydrolase (protein)
Unique Ligands	CA, CAX

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1UZ9 \| pdb_00001uz9	Download File View File

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins.

Whittingham, J.L., Jonassen, I., Havelund, S., Roberts, S.M., Dodson, E.J., Verma, C.S., Wilkinson, A.J., Dodson, G.G.

(2004) Biochemistry 43: 5987

Released	2005-03-03
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	CL, CRS, UZ9, ZN

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1VYQ \| pdb_00001vyq	Download File View File

Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design

Whittingham, J.L., Leal, I., Kasinathan, G., Nguyen, C., Bell, E., Jones, A.F., Berry, C., Benito, A., Turkenburg, J.P., Dodson, E.J., Ruiz Perez, L.M., Wilkinson, A.J., Johansson, N.G., Brun, R., Gilbert, I.H., Gonzalez Pacanowska, D., Wilson, K.S.

(2005) Structure 13: 329

Released	2005-05-26
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE (protein)
Unique Ligands	DUX

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1W8P \| pdb_00001w8p	Download File View File

Structural properties of the B25Tyr-NMe-B26Phe insulin mutant.

Zakowa, L., Au-Alvarez, O., Dodson, E.J., Dodson, G.G., Brzozowski, A.M.

(2004) Biochemistry 43: 16293

Released	2005-02-03
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Homo sapiens
Macromolecule	INSULIN A-CHAIN (protein) INSULIN B-CHAIN (protein)
Unique Ligands	IPH, ZN

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1XDA \| pdb_00001xda	Download File View File

STRUCTURE OF INSULIN

Whittingham, J.L., Havelund, S., Jonassen, I.

(1997) Biochemistry 36: 2826-2831

Released	1997-07-07
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	FATTY ACID ACYLATED INSULIN (protein)
Unique Ligands	CL, IPH, MYR, ZN

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1ZEG \| pdb_00001zeg	Download File View File

STRUCTURE OF B28 ASP INSULIN IN COMPLEX WITH PHENOL

Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.

(1998) Biochemistry 37: 11516-11523

Released	1998-07-15
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	CL, IPH, ZN

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1ZEH \| pdb_00001zeh	Download File View File

STRUCTURE OF INSULIN

Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.

(1998) Biochemistry 37: 11516-11523

Released	1998-12-09
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	CL, CRS, ZN

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1ZEI \| pdb_00001zei	Download File View File

CROSS-LINKED B28 ASP INSULIN

Whittingham, J.L., Edwards, E.J., Antson, A.A., Clarkson, J.M., Dodson, G.G.

(1998) Biochemistry 37: 11516-11523

Released	1999-02-16
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Sus scrofa
Macromolecule	INSULIN (protein)
Unique Ligands	CL, CRS, ZN

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1ZNJ \| pdb_00001znj	Download File View File

INSULIN, MONOCLINIC CRYSTAL FORM

Turkenburg, M.G.W., Whittingham, J.L., Turkenburg, J.P., Dodson, G.G., Derewenda, U., Smith, G.D., Dodson, E.J., Derewenda, Z.S., Xiao, B.

To be published

Released	1998-01-28
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	CL, IPH, ZN

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2CEU \| pdb_00002ceu	Download File View File

Despentapeptide insulin in acetic acid (pH 2)

Whittingham, J.L., Zhang, Y., Zakova, L., Dodson, E.J., Turkenburg, J.P., Brange, J., Dodson, G.G.

(2006) Acta Crystallogr D Biol Crystallogr 62: 505

Released	2006-03-03
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	INSULIN (protein)
Unique Ligands	SO4

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2J5G \| pdb_00002j5g	Download File View File

The Native structure of a beta-Diketone Hydrolase from the Cyanobacterium Anabaena sp. PCC 7120

Bennett, J.P., Whittingham, J.L., Brzozowski, A.M., Leonard, P.M., Grogan, G.

(2007) Biochemistry 46: 137

Released	2007-01-16
Method	X-RAY DIFFRACTION 1.46 Å
Organisms	Nostoc sp. PCC 7120 = FACHB-418
Macromolecule	ALR4455 PROTEIN (protein)
Unique Ligands	SO4

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2J5S \| pdb_00002j5s	Download File View File

Structural of ABDH, a beta-diketone hydrolase from the Cyanobacterium Anabaena sp. PCC 7120 bound to (S)-3-oxocyclohexyl acetic acid

Bennett, J.P., Whittingham, J.L., Brzozowski, A.M., Leonard, P.M., Grogan, G.

(2007) Biochemistry 46: 137

Released	2007-01-08
Method	X-RAY DIFFRACTION 1.57 Å
Organisms	Nostoc sp. PCC 7120 = FACHB-418
Macromolecule	BETA-DIKETONE HYDROLASE (protein)
Unique Ligands	KTA, NI

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2TCI \| pdb_00002tci	Download File View File

X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL

Whittingham, J.L., Dodson, E.J., Moody, P.C.E., Dodson, G.G.

(1995) Biochemistry 34: 15553-15563

Released	1996-01-29
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Sus scrofa
Macromolecule	THIOCYANATE INSULIN (protein)
Unique Ligands	SCN, ZN

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2WWF \| pdb_00002wwf	Download File View File

Plasmodium falciparum thymidylate kinase in complex with TMP and ADP

Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P.G., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.

(2010) Biochem J 428: 499

Released	2010-04-21
Method	X-RAY DIFFRACTION 1.89 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	THYMIDILATE KINASE, PUTATIVE (protein)
Unique Ligands	ADP, GOL, NA, TMP

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2WWG \| pdb_00002wwg	Download File View File

Plasmodium falciparum thymidylate kinase in complex with dGMP and ADP

Whittingham, J.L., Carrero-Lerida, J., Brannigan, J.A., Ruiz-Perez, L.M., Silva, A.P., Fogg, M.J., Wilkinson, A.J., Gilbert, I.H., Wilson, K.S., Gonzalez-Pacanowska, D.

(2010) Biochem J 428: 499

Released	2010-04-21
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	THYMIDILATE KINASE, PUTATIVE (protein)
Unique Ligands	ADP, DGP, GOL, NA

1 to 25 of 45 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1G7A | pdb_00001g7a

1G7B | pdb_00001g7b

1GUJ | pdb_00001guj

1MPJ | pdb_00001mpj

1O8U | pdb_00001o8u

1PID | pdb_00001pid

1QIY | pdb_00001qiy

1QIZ | pdb_00001qiz

1QJ0 | pdb_00001qj0

1RWE | pdb_00001rwe

1SZO | pdb_00001szo

1UZ9 | pdb_00001uz9

1VYQ | pdb_00001vyq

1W8P | pdb_00001w8p

1XDA | pdb_00001xda

1ZEG | pdb_00001zeg

1ZEH | pdb_00001zeh

1ZEI | pdb_00001zei

1ZNJ | pdb_00001znj

2CEU | pdb_00002ceu

2J5G | pdb_00002j5g

2J5S | pdb_00002j5s

2TCI | pdb_00002tci

2WWF | pdb_00002wwf

2WWG | pdb_00002wwg