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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Chemical ID(s) = PT1

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This query matches 11 Structures.

Refinements

Structure Determination Methodology

experimental (11)

Scientific Name of Source Organism

	Plasmodium falciparum (3)
	Bacillus anthracis str. A2012 (1)
	Clostridioides difficile (1)
	Coxiella burnetii (1)
	Escherichia coli CFT073 (1)
	Ricinus communis (1)
	Sambucus ebulus (1)
	Yersinia pestis (1)
	uncultured bacterium (1)

Taxonomy

	Bacteria (6)
	Eukaryota (5)

Experimental Method

X-RAY DIFFRACTION (11)

Polymer Entity Type

Protein (11)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (5)
	2.5 - 3.0 (3)
	3.0 - 3.5 (1)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (2)
	2010 - 2014 (2)
	2015 - 2019 (2)
	2020 - 2024 (4)

Enzyme Classification Name

	Transferases (5)
	Hydrolases (2)

Symmetry Type

	Cyclic (10)
	Asymmetric (3)

SCOP Classification

	Alpha and beta proteins (a/b) (5)
	Alpha and beta proteins (a+b) (2)
	Artifacts (2)
	All beta proteins (1)

AllSelected

1 to 11 of 11 Structures

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1BR6 \| pdb_00001br6	Download File View File

RICIN A CHAIN (RECOMBINANT) COMPLEX WITH PTEROIC ACID

Hollis, T., Yan, X., Svinth, M., Day, P., Monzingo, A.F., Milne, G.W.A., Robertus, J.D.

(1997) J Mol Biology 266: 1043-1049

Released	1998-09-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Ricinus communis
Macromolecule	PROTEIN (RICIN) (protein)
Unique Ligands	PT1

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1HWP \| pdb_00001hwp	Download File View File

EBULIN COMPLEXED WITH PTEROIC ACID, TRIGONAL CRYSTAL FORM

Pascal, J.M., Day, P.J., Monzingo, A.F., Ernst, S.R., Robertus, J.D.

(2001) Proteins 43: 319-326

Released	2001-01-24
Method	X-RAY DIFFRACTION 3.1 Å
Organisms	Sambucus ebulus
Macromolecule	EBULIN (protein)
Unique Ligands	PT1
Unique branched monosaccharides	BGC, BMA, GAL, NAG

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1TX0 \| pdb_00001tx0	Download File View File

Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis

Babaoglu, K., Qi, J., Lee, R.E., White, S.W.

(2004) Structure 12: 1705-1717

Released	2004-09-14
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Bacillus anthracis str. A2012
Macromolecule	DHPS, Dihydropteroate synthase (protein)
Unique Ligands	PT1, SO4

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3TR9 \| pdb_00003tr9	Download File View File

Structure of a dihydropteroate synthase (folP) in complex with pteroic acid from Coxiella burnetii

Cheung, J., Franklin, M.C., Rudolph, M., Cassidy, M., Gary, E., Burshteyn, F., Love, J.

(2015) Proteins 83: 2124-2136

Released	2011-09-28
Method	X-RAY DIFFRACTION 1.895 Å
Organisms	Coxiella burnetii
Macromolecule	Dihydropteroate synthase (protein)
Unique Ligands	CL, NA, PT1

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3TYU \| pdb_00003tyu	Download File View File

Crystal Structure of Dihydropteroate synthetase with Product1

Yun, M.K.

(2012) Science 335: 1110-1114

Released	2012-03-14
Method	X-RAY DIFFRACTION 2.7 Å
Organisms	Yersinia pestis
Macromolecule	7,8-dihydropteroate synthase (protein)
Unique Ligands	PT1

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5U10 \| pdb_00005u10	Download File View File

E. coli dihydropteroate synthase complexed with pteroic acid

Dennis, M.L., Peat, T.S., Swarbrick, J.D.

(2018) Chemistry 24: 1922-1930

Released	2017-12-06
Method	X-RAY DIFFRACTION 2.04 Å
Organisms	Escherichia coli CFT073
Macromolecule	Dihydropteroate synthase (protein)
Unique Ligands	PO4, PT1

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6JWR \| pdb_00006jwr	Download File View File

Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate

Chitnumsub, P., Jaruwat, A., Yuthavong, Y.

(2020) FEBS J 287: 3273-3297

Released	2020-02-12
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Plasmodium falciparum
Macromolecule	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (protein)
Unique Ligands	ACT, AMP, CA, MG, PH2, PT1

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6JWS \| pdb_00006jws	Download File View File

Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with Pteroate

Chitnumsub, P., Jaruwat, A., Yuthavong, Y.

(2020) FEBS J 287: 3273-3297

Released	2020-02-12
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Plasmodium falciparum
Macromolecule	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (protein)
Unique Ligands	ACT, ATP, CA, MG, PT1

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6JWT \| pdb_00006jwt	Download File View File

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate

Chitnumsub, P., Jaruwat, A., Yuthavong, Y.

(2020) FEBS J 287: 3273-3297

Released	2020-02-12
Method	X-RAY DIFFRACTION 2.56 Å
Organisms	Plasmodium falciparum
Macromolecule	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase (protein)
Unique Ligands	ACT, AMP, ATP, CA, MG, PT1

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6PZ2 \| pdb_00006pz2	Download File View File

Crystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the presence of pteroic acid

Girardi, N.M., Thoden, J.B., Holden, H.M.

To be published

Released	2019-11-27
Method	X-RAY DIFFRACTION 2 Å
Organisms	Clostridioides difficile
Macromolecule	Dihydropteroate synthase (protein)
Unique Ligands	NHE, PT1, SO4

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8D5I \| pdb_00008d5i	Download File View File

Crystal structure of dihydropteroate synthase H182G mutant (folP-SMZ_B27) from soil uncultured bacterium in complex with pteroic acid and pyrophosphate

Stogios, P.J., Skarina, T., Kim, Y., Di Leo, R., Venkatesan, M., Savchenko, A., Joachimiak, A., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)

To be published

Released	2022-06-15
Method	X-RAY DIFFRACTION 1.82 Å
Organisms	uncultured bacterium
Macromolecule	folP-SMZ_B27 (protein)
Unique Ligands	POP, PT1

1 to 11 of 11 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1BR6 | pdb_00001br6

RICIN A CHAIN (RECOMBINANT) COMPLEX WITH PTEROIC ACID

1HWP | pdb_00001hwp

EBULIN COMPLEXED WITH PTEROIC ACID, TRIGONAL CRYSTAL FORM

1TX0 | pdb_00001tx0

Dihydropteroate Synthetase, With Bound Product Analogue Pteroic Acid, From Bacillus anthracis

3TR9 | pdb_00003tr9

Structure of a dihydropteroate synthase (folP) in complex with pteroic acid from Coxiella burnetii

3TYU | pdb_00003tyu

Crystal Structure of Dihydropteroate synthetase with Product1

5U10 | pdb_00005u10

E. coli dihydropteroate synthase complexed with pteroic acid

6JWR | pdb_00006jwr

Crystal structure of Plasmodium falciparum HPPK-DHPS wild type with Pteroate

6JWS | pdb_00006jws

Crystal structure of Plasmodium falciparum HPPK-DHPS A437G with Pteroate

6JWT | pdb_00006jwt

Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate

6PZ2 | pdb_00006pz2

Crystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the presence of pteroic acid

8D5I | pdb_00008d5i

Crystal structure of dihydropteroate synthase H182G mutant (folP-SMZ_B27) from soil uncultured bacterium in complex with pteroic acid and pyrophosphate

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1BR6 | pdb_00001br6

1HWP | pdb_00001hwp

1TX0 | pdb_00001tx0

3TR9 | pdb_00003tr9

3TYU | pdb_00003tyu

5U10 | pdb_00005u10

6JWR | pdb_00006jwr

6JWS | pdb_00006jws

6JWT | pdb_00006jwt

6PZ2 | pdb_00006pz2

8D5I | pdb_00008d5i