RCSB PDB: Search

Warning You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.

Help

Help

RCSB PDB

Deposit
- PDBx/mmCIF file
- pdb_extract
- SF-Tool
- Ligand Expo
- MAXIT
- Validation Server
- Validation API
- Information for Journals
- Validation Task Forces
- wwPDB OneDep System
- PDB-IHM
Search
Visualize
Analyze
Download
Learn
- Training Courses
- Guide to PDB Data
- Molecule of the Month
- Educational Resources
- Curricula
- Browse
- News
- SciArt Galleries
- Irving Geis
- David Goodsell
About
Careers
COVID-19

233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

	Include CSM
Advanced Search \| Browse Annotations		Help

Search
Query History
Browse Annotations
MyPDB

QUERY: Gene Name = "BCL2L3"

MyPDB Login

Search API

Advanced Search Query Builder

Help

Full Text

Structure Attributes

Help

NOT

Count

Add Subquery

Chemical Attributes

Sequence Similarity

Sequence Motif

Structure Similarity

Structure Motif

Chemical Similarity

Return

grouped by

Include Computed Structure Models (CSM)

Count

Clear

Search Summary

This query matches 124 Structures.

Refinements

Structure Determination Methodology

experimental (124)

Scientific Name of Source Organism

	Homo sapiens (124)
	Escherichia coli K-12 (10)
	synthetic construct (9)
	Escherichia coli O157:H7 (8)
	Escherichia coli (6)
	Mus musculus (6)
	Serratia sp. FS14 (6)
	saltans group (1)

Taxonomy

	Eukaryota (124)
	Bacteria (30)
	other sequences (9)
	Eukaryota (eukaryotes) (1)

Experimental Method

	X-RAY DIFFRACTION (122)
	SOLUTION NMR (2)

Polymer Entity Type

Protein (124)

Refinement Resolution (Å)

	1.0 - 1.5 (9)
	1.5 - 2.0 (50)
	2.0 - 2.5 (45)
	2.5 - 3.0 (18)

Release Date

	2005 - 2009 (1)
	2010 - 2014 (15)
	2015 - 2019 (70)
	2020 - 2024 (34)
	2025 - 2029 (4)

Enzyme Classification Name

	Hydrolases (1)
	Transferases (1)

Symmetry Type

	Asymmetric (123)
	Cyclic (10)
	Dihedral (2)

SCOP Classification

	Membrane and cell surface proteins and peptides (65)
	Artifacts (34)
	All beta proteins (7)

AllSelected

1 to 25 of 124 Structures

Page 1 of 5

Sort by

Explore in 3D

2MHS \| pdb_00002mhs	Download File View File

NMR Structure of human Mcl-1

Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.

(2014) PLoS One 9: e96521-e96521

Released	2014-05-14
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)

Explore in 3D

3IO9 \| pdb_00003io9	Download File View File

BimL12Y in complex with Mcl-1

Czabotar, P.E., Lee, E.F., Yang, H., Sleebs, B.E., Lessene, G., Colman, P.M., Smith, B.J., Fairlie, W.D.

(2009) J Biological Chem 284: 30508-30517

Released	2009-09-01
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ZN

Explore in 3D

3KJ0 \| pdb_00003kj0	Download File View File

Mcl-1 in complex with Bim BH3 mutant I2dY

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	TRS

Explore in 3D

3KJ1 \| pdb_00003kj1	Download File View File

Mcl-1 in complex with Bim BH3 mutant I2dA

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 1.945 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ACT, CL, ZN

Explore in 3D

3KJ2 \| pdb_00003kj2	Download File View File

Mcl-1 in complex with Bim BH3 mutant F4aE

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.351 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ACT, ZN

Explore in 3D

3KZ0 \| pdb_00003kz0	Download File View File

MCL-1 complex with MCL-1-specific selected peptide

Dutta, S., Fire, E., Grant, R.A., Sauer, R.T., Keating, A.E.

(2010) J Mol Biology 398: 747-762

Released	2010-05-05
Method	X-RAY DIFFRACTION 2.349 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein) Mcl-1 specific peptide MB7 (protein)
Unique Ligands	SO4, ZN

Explore in 3D

3MK8 \| pdb_00003mk8	Download File View File

The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer

Stewart, M., Fire, E., Keating, A.E., Walensky, L.D.

(2010) Nat Chem Biol 6: 595-601

Released	2010-06-23
Method	X-RAY DIFFRACTION 2.321 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)

Explore in 3D

3PK1 \| pdb_00003pk1	Download File View File

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Czabotar, P.E., Colman, P.M.

(2011) J Biological Chem 286: 7123-7131

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.486 Å
Organisms	Homo sapiens
Macromolecule	Apoptosis regulator BAX (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	CD

Explore in 3D

3WIX \| pdb_00003wix	Download File View File

Crystal structure of Mcl-1 in complex with compound 4

Sogabe, S., Igaki, S., Hayano, Y.

(2013) J Med Chem 56: 9635-9645

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LC3

Explore in 3D

3WIY \| pdb_00003wiy	Download File View File

Crystal structure of Mcl-1 in complex with compound 10

Sogabe, S., Igaki, S., Hayano, Y.

(2013) J Med Chem 56: 9635-9645

Released	2013-11-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LC6

Explore in 3D

4HW2 \| pdb_00004hw2	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	19H, EDO, PGE

Explore in 3D

4HW3 \| pdb_00004hw3	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	19G

Explore in 3D

4HW4 \| pdb_00004hw4	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Friberg, A., Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein) Mcl-1 BH3 peptide (protein)

Explore in 3D

4OQ5 \| pdb_00004oq5	Download File View File

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.

(2014) Bioorg Med Chem Lett 24: 1484-1488

Released	2014-03-12
Method	X-RAY DIFFRACTION 2.86 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	2UU

Explore in 3D

4OQ6 \| pdb_00004oq6	Download File View File

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid

Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.

(2014) Bioorg Med Chem Lett 24: 1484-1488

Released	2014-03-12
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	2UV

Explore in 3D

4WGI \| pdb_00004wgi	Download File View File

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

Clifton, M.C., Fairman, J.W., Fang, C., D'Souza, B., Fulroth, B., Leed, A., McCarren, P., Wang, L., Wang, Y., Kaushik, V., Palmer, M., Wei, G., Golub, T.R., Hubbard, B.K., Serrano-Wu, M.H.

(2014) ACS Med Chem Lett 5: 1308-1312

Released	2014-11-19
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Escherichia coli O157:H7 Homo sapiens
Macromolecule	Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	3M6, FMT, MG
Unique branched monosaccharides	GLC

Explore in 3D

4WMR \| pdb_00004wmr	Download File View File

STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A

CLIFTON, M.C., EDWARDS, T.E.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	865, POP, ZN

Explore in 3D

4WMS \| pdb_00004wms	Download File View File

STRUCTURE OF APO MBP-MCL1 AT 1.9A

Clifton, M.C., Dranow, D.M.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBP-MCL1 chimera protein (protein)
Unique Ligands	EDO, FMT, MG
Unique branched monosaccharides	GLC

Explore in 3D

4WMT \| pdb_00004wmt	Download File View File

STRUCTURE OF MBP-MCL1 BOUND TO ligand 1 AT 2.35A

Clifton, M.C., Dranow, D.M.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBP-MCL1 chimera protein (protein)
Unique Ligands	865, EDO, FMT
Unique branched monosaccharides	GLC

Explore in 3D

4WMU \| pdb_00004wmu	Download File View File

STRUCTURE OF MBP-MCL1 BOUND TO ligand 2 AT 1.55A

Clifton, M.C., Faiman, J.W.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBP-MCL1 chimera protein,Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	19H, EDO, FMT, MG, NA
Unique branched monosaccharides	GLC

Explore in 3D

4WMV \| pdb_00004wmv	Download File View File

STRUCTURE OF MBP-MCL1 BOUND TO ligand 4 AT 2.4A

Clifton, M.C., Moulin, A.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBL-MCL1 chimera protein (protein)
Unique Ligands	3R4, CL, MG
Unique branched monosaccharides	GLC

Explore in 3D

4WMW \| pdb_00004wmw	Download File View File

The structure of MBP-MCL1 bound to ligand 5 at 1.9A

Clifton, M.C., Dranow, D.M.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBP-MCL1 chimera protein (protein)
Unique Ligands	3R6, EDO, FMT, MG
Unique branched monosaccharides	GLC

Explore in 3D

4WMX \| pdb_00004wmx	Download File View File

The structure of MBP-MCL1 bound to ligand 6 at 2.0A

Clifton, M.C., Dranow, D.M.

(2015) PLoS One 10: e0125010-e0125010

Released	2015-05-06
Method	X-RAY DIFFRACTION 2 Å
Organisms	Escherichia coli K-12 Homo sapiens
Macromolecule	MBP-MCL1 chimera protein (protein)
Unique Ligands	3R7, FMT, MG
Unique branched monosaccharides	GLC

Explore in 3D

4ZBF \| pdb_00004zbf	Download File View File

Mcl-1 complexed with small molecules

Zhao, B.

(2015) J Med Chem 58: 3794-3805

Released	2015-04-29
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	4M7

Explore in 3D

4ZBI \| pdb_00004zbi	Download File View File

Mcl-1 complexed with small molecules

Zhao, B.

(2015) J Med Chem 58: 3794-3805

Released	2015-04-29
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	4M6

1 to 25 of 124 Structures

Page 1 of 5

Sort by

About
About Us
Citing Us
Publications
Team
Careers
Usage & Privacy

Support
Contact Us
Help
Website FAQ
Glossary
Service Status

RCSB PDB is hosted by

RCSB PDB is a member of the

RCSB Partners
Nucleic Acid Knowledgebase

wwPDB Partners
RCSB PDB
PDBe
PDBj
BMRB
EMDB

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

Prepare Data

Validate Data

Deposit Data

Help and Resources

Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2MHS | pdb_00002mhs

3IO9 | pdb_00003io9

3KJ0 | pdb_00003kj0

3KJ1 | pdb_00003kj1

3KJ2 | pdb_00003kj2

3KZ0 | pdb_00003kz0

3MK8 | pdb_00003mk8

3PK1 | pdb_00003pk1

3WIX | pdb_00003wix

3WIY | pdb_00003wiy

4HW2 | pdb_00004hw2

4HW3 | pdb_00004hw3

4HW4 | pdb_00004hw4

4OQ5 | pdb_00004oq5

4OQ6 | pdb_00004oq6

4WGI | pdb_00004wgi

4WMR | pdb_00004wmr

4WMS | pdb_00004wms

4WMT | pdb_00004wmt

4WMU | pdb_00004wmu

4WMV | pdb_00004wmv

4WMW | pdb_00004wmw

4WMX | pdb_00004wmx

4ZBF | pdb_00004zbf

4ZBI | pdb_00004zbi