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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "GCN5"

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Search Summary

This query matches 18 Structures.

Refinements

Structure Determination Methodology

experimental (18)

Scientific Name of Source Organism

	Homo sapiens (15)
	Saccharomyces cerevisiae (3)
	Saccharomyces cerevisiae S288C (2)
	Plasmodium falciparum 3D7 (1)

Taxonomy

Eukaryota (18)

Experimental Method

X-RAY DIFFRACTION (18)

Polymer Entity Type

Protein (18)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (6)
	2.0 - 2.5 (5)
	2.5 - 3.0 (4)
	3.0 - 3.5 (2)

Release Date

	1995 - 1999 (1)
	2000 - 2004 (1)
	2005 - 2009 (2)
	2010 - 2014 (1)
	2015 - 2019 (8)
	2020 - 2024 (5)

Enzyme Classification Name

Transferases (17)

Symmetry Type

	Asymmetric (11)
	Cyclic (4)
	Octahedral (3)

SCOP Classification

	Alpha and beta proteins (a+b) (6)
	All alpha proteins (5)
	All beta proteins (2)
	Artifacts (5)

AllSelected

1 to 18 of 18 Structures

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1E6I \| pdb_00001e6i	Download File View File

Bromodomain from GCN5 complexed with acetylated H4 peptide

Owen, D.J., Travers, A.A., Evans, P.R.

(2000) EMBO J 19: 6141

Released	2000-11-24
Method	X-RAY DIFFRACTION 1.87 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	HISTONE H4 (protein) TRANSCRIPTIONAL ACTIVATOR GCN5 (protein)

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1YGH \| pdb_00001ygh	Download File View File

HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE

Trievel, R.C., Rojas, J.R., Sterner, D.E., Venkataramani, R., Wang, L., Zhou, J., Allis, C.D., Berger, S.L., Marmorstein, R.

(1999) Proc Natl Acad Sci U S A 96: 8931-8936

Released	1999-08-02
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	PROTEIN (TRANSCRIPTIONAL ACTIVATOR GCN5) (protein)
Unique Ligands	GOL

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1Z4R \| pdb_00001z4r	Download File View File

Human GCN5 Acetyltransferase

Dong, A., Bernstein, G., Schuetz, A., Antoshenko, T., Wu, H., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Plotnikov, A., Structural Genomics Consortium (SGC)

(2007) Proteins 68: 403-407

Released	2005-03-29
Method	X-RAY DIFFRACTION 1.74 Å
Organisms	Homo sapiens
Macromolecule	General control of amino acid synthesis protein 5-like 2 (protein)
Unique Ligands	ACO

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3D7C \| pdb_00003d7c	Download File View File

Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis protein 5-like 2

Filippakopoulos, P., Eswaran, J., Picaud, S., Fedorov, O., Murray, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2008-07-15
Method	X-RAY DIFFRACTION 2.06 Å
Organisms	Homo sapiens
Macromolecule	General control of amino acid synthesis protein 5-like 2 (protein)

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4QNS \| pdb_00004qns	Download File View File

Crystal structure of bromodomain from Plasmodium faciparum GCN5, PF3D7_0823300

Fonseca, M., Tallant, C., Knapp, S., Loppnau, P., von Delft, F., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hui, R., Structural Genomics Consortium (SGC)

To be published

Released	2014-07-16
Method	X-RAY DIFFRACTION 1.497 Å
Organisms	Plasmodium falciparum 3D7
Macromolecule	Histone acetyltransferase GCN5, putative (protein)
Unique Ligands	ACT, EDO, SO4

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5H84 \| pdb_00005h84	Download File View File

Human Gcn5 bound to propionyl-CoA

Wolberger, C., Ringel, A.E.

(2016) Acta Crystallogr D Struct Biol 72: 841-848

Released	2016-03-23
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	1VU, EDO, IPA

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5H86 \| pdb_00005h86	Download File View File

Human Gcn5 bound to butyryl-CoA

Wolberger, C., Ringel, A.E.

(2016) Acta Crystallogr D Struct Biol 72: 841-848

Released	2016-03-23
Method	X-RAY DIFFRACTION 2.08 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	BCO, EDO

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5MLJ \| pdb_00005mlj	Download File View File

Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

Chung, C.-W.

(2017) J Med Chem 60: 695-709

Released	2017-12-20
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	9ST, EDO

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5TRL \| pdb_00005trl	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain

Guo, Y.R., Tao, Y.J.

(2017) Nature 552: 273-277

Released	2017-12-06
Method	X-RAY DIFFRACTION 2.299 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	SCA

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5TRM \| pdb_00005trm	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain

Guo, Y.R., Tao, Y.J.

(2017) Nature 552: 273-277

Released	2017-12-06
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)

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6CW2 \| pdb_00006cw2	Download File View File

Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 1

Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S.

(2018) Proc Natl Acad Sci U S A 115: 10010-10015

Released	2018-09-19
Method	X-RAY DIFFRACTION 2.67 Å
Organisms	Homo sapiens Saccharomyces cerevisiae Saccharomyces cerevisiae S288C
Macromolecule	Histone acetyltransferase GCN5 (protein) Transcriptional adapter 2 (protein) antibody heavy chain (protein) antibody light chain (protein)
Unique Ligands	ZN

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6CW3 \| pdb_00006cw3	Download File View File

Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2

Sun, J., Paduch, M., Kim, S.A., Kramer, R.M., Barrios, A.F., Lu, V., Luke, J., Usatyuk, S., Kossiakoff, A.A., Tan, S.

(2018) Proc Natl Acad Sci U S A 115: 10010-10015

Released	2018-09-19
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Homo sapiens Saccharomyces cerevisiae S288C
Macromolecule	Histone acetyltransferase GCN5 (protein) Transcriptional adapter 2 (protein) antibody heavy chain (protein) antibody light chain (protein)
Unique Ligands	ZN

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6J3P \| pdb_00006j3p	Download File View File

Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n

Huang, L.Y., Li, H., Niu, L., Wu, C.Y., Yu, Y.M., Li, L.L., Yang, S.Y.

(2019) J Med Chem 62: 4526-4542

Released	2019-05-01
Method	X-RAY DIFFRACTION 1.598 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	B8O

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8E6O \| pdb_00008e6o	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain

Lu, X.T., Tao, Y.J.

To be published

Released	2024-02-28
Method	X-RAY DIFFRACTION 2.37 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	UQ3

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8H65 \| pdb_00008h65	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain bound with butyryl-CoA

Li, N., Tao, Y.J., Guo, Y.R.

(2023) Research (Wash D C) 6: 0109-0109

Released	2023-05-03
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	BCO

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8H66 \| pdb_00008h66	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain bound with propionyl-CoA

Li, N., Tao, Y.J., Guo, Y.R.

(2023) Research (Wash D C) 6: 0109-0109

Released	2023-05-03
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	1VU

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8H6C \| pdb_00008h6c	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain bound with malonyl-CoA

Li, N., Tao, Y.J., Guo, Y.R.

(2023) Research (Wash D C) 6: 0109-0109

Released	2023-05-03
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	MLC

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8H6D \| pdb_00008h6d	Download File View File

Crystal structure of human GCN5 histone acetyltransferase domain bound with glutaryl-CoA

Li, N., Tao, Y.J., Guo, Y.R.

(2023) Research (Wash D C) 6: 0109-0109

Released	2023-05-03
Method	X-RAY DIFFRACTION 3.26 Å
Organisms	Homo sapiens
Macromolecule	Histone acetyltransferase KAT2A (protein)
Unique Ligands	GRA

1 to 18 of 18 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1E6I | pdb_00001e6i

Bromodomain from GCN5 complexed with acetylated H4 peptide

1YGH | pdb_00001ygh

HAT DOMAIN OF GCN5 FROM SACCHAROMYCES CEREVISIAE

1Z4R | pdb_00001z4r

Human GCN5 Acetyltransferase

3D7C | pdb_00003d7c

Crystal structure of the bromodomain of human GCN5, the general control of amino-acid synthesis protein 5-like 2

4QNS | pdb_00004qns

Crystal structure of bromodomain from Plasmodium faciparum GCN5, PF3D7_0823300

5H84 | pdb_00005h84

Human Gcn5 bound to propionyl-CoA

5H86 | pdb_00005h86

Human Gcn5 bound to butyryl-CoA

5MLJ | pdb_00005mlj

Bromodomain of Human GCN5 with 4-bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

5TRL | pdb_00005trl

Crystal structure of human GCN5 histone acetyltransferase domain

5TRM | pdb_00005trm

Crystal structure of human GCN5 histone acetyltransferase domain

6CW2 | pdb_00006cw2

Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 1

6CW3 | pdb_00006cw3

Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2

6J3P | pdb_00006j3p

Crystal structure of the human GCN5 bromodomain in complex with compound (R,R)-36n

8E6O | pdb_00008e6o

Crystal structure of human GCN5 histone acetyltransferase domain

8H65 | pdb_00008h65

Crystal structure of human GCN5 histone acetyltransferase domain bound with butyryl-CoA

8H66 | pdb_00008h66

Crystal structure of human GCN5 histone acetyltransferase domain bound with propionyl-CoA

8H6C | pdb_00008h6c

Crystal structure of human GCN5 histone acetyltransferase domain bound with malonyl-CoA

8H6D | pdb_00008h6d

Crystal structure of human GCN5 histone acetyltransferase domain bound with glutaryl-CoA

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1E6I | pdb_00001e6i

1YGH | pdb_00001ygh

1Z4R | pdb_00001z4r

3D7C | pdb_00003d7c

4QNS | pdb_00004qns

5H84 | pdb_00005h84

5H86 | pdb_00005h86

5MLJ | pdb_00005mlj

5TRL | pdb_00005trl

5TRM | pdb_00005trm

6CW2 | pdb_00006cw2

6CW3 | pdb_00006cw3

6J3P | pdb_00006j3p

8E6O | pdb_00008e6o

8H65 | pdb_00008h65

8H66 | pdb_00008h66

8H6C | pdb_00008h6c

8H6D | pdb_00008h6d