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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "KIAA1420"

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Search Summary

This query matches 13 Structures.

Refinements

Structure Determination Methodology

experimental (13)

Scientific Name of Source Organism

Homo sapiens (13)

Taxonomy

Eukaryota (13)

Experimental Method

	X-RAY DIFFRACTION (12)
	SOLUTION NMR (1)

Polymer Entity Type

Protein (13)

Refinement Resolution (Å)

	1.5 - 2.0 (2)
	2.0 - 2.5 (4)
	2.5 - 3.0 (5)
	3.0 - 3.5 (1)

Release Date

	2010 - 2014 (2)
	2015 - 2019 (7)
	2020 - 2024 (3)
	2025 - 2029 (1)

Enzyme Classification Name

Transferases (13)

Symmetry Type

	Asymmetric (13)
	Cyclic (1)

SCOP Classification

	All alpha proteins (1)
	Artifacts (1)
	Membrane and cell surface proteins and peptides (1)

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1 to 13 of 13 Structures

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Explore in 3D

3MQM \| pdb_00003mqm	Download File View File

Crystal Structure of the Bromodomain of human ASH1L

Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2010-05-19
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)

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3OPE \| pdb_00003ope	Download File View File

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

An, S., Song, J.

(2011) J Biological Chem 286: 8369-8374

Released	2011-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YNM \| pdb_00004ynm	Download File View File

ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.-J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.19 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YNP \| pdb_00004ynp	Download File View File

ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.-J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPA \| pdb_00004ypa	Download File View File

ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPE \| pdb_00004ype	Download File View File

ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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4YPU \| pdb_00004ypu	Download File View File

ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM)

Rogawski, D.S., Ndoj, J., Cho, H.J., Maillard, I., Grembecka, J., Cierpicki, T.

(2015) Biochemistry 54: 5401-5413

Released	2015-09-02
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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6AGO \| pdb_00006ago	Download File View File

Crystal structure of MRG15-ASH1L Histone methyltransferase complex

Lee, Y., Song, J.

(2019) Structure 27: 846

Released	2019-03-13
Method	X-RAY DIFFRACTION 3.103 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein) Mortality factor 4 like 1 (protein)
Unique Ligands	SAM, ZN

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6INE \| pdb_00006ine	Download File View File

Crystal Structure of human ASH1L-MRG15 complex

Hou, P., Huang, C., Liu, C.P., Yu, T., Yin, Y., Zhu, B., Xu, R.M.

(2019) Structure 27: 837

Released	2019-03-20
Method	X-RAY DIFFRACTION 2.6 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein) Mortality factor 4-like protein 1 (protein)
Unique Ligands	GOL, SAM, ZN

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6WZW \| pdb_00006wzw	Download File View File

Ash1L SET domain in complex with AS-85

Li, H., Deng, J., Cierpicki, T., Grembecka, J.

(2021) Nat Commun 12: 2792-2792

Released	2021-04-07
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	EPE, SAM, UG7, ZN

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6X0P \| pdb_00006x0p	Download File View File

Ash1L SET domain Q2265A mutant in complex with AS-5

Rogawski, D.S., Li, H., Borkin, D., Cierpicki, T., Grembecka, J.

(2021) Nat Commun 12: 2792-2792

Released	2021-04-07
Method	X-RAY DIFFRACTION 1.69 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, UK7, ZN

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7Y0I \| pdb_00007y0i	Download File View File

Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide

Yu, M., Zeng, L.

(2022) Front Oncol 12: 906807-906807

Released	2022-10-12
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	ALA-ARG-THR-MLY-GLN-THR-ALA-ARG-LYS-SER-THR-GLY-GLY-LYS-ALA (protein) Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	ZN

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8VLH \| pdb_00008vlh	Download File View File

Crystal structure of Ash1L PHD-BAH domains

Vann, K.R., Tencer, A.H., Kutateladze, T.G.

(2025) Nat Commun 16: 2235-2235

Released	2025-03-19
Method	X-RAY DIFFRACTION 2.403 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SR, ZN

1 to 13 of 13 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

3MQM | pdb_00003mqm

Crystal Structure of the Bromodomain of human ASH1L

3OPE | pdb_00003ope

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

4YNM | pdb_00004ynm

ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM)

4YNP | pdb_00004ynp

ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM)

4YPA | pdb_00004ypa

ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)

4YPE | pdb_00004ype

ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)

4YPU | pdb_00004ypu

ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM)

6AGO | pdb_00006ago

Crystal structure of MRG15-ASH1L Histone methyltransferase complex

6INE | pdb_00006ine

Crystal Structure of human ASH1L-MRG15 complex

6WZW | pdb_00006wzw

Ash1L SET domain in complex with AS-85

6X0P | pdb_00006x0p

Ash1L SET domain Q2265A mutant in complex with AS-5

7Y0I | pdb_00007y0i

Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide

8VLH | pdb_00008vlh

Crystal structure of Ash1L PHD-BAH domains

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

3MQM | pdb_00003mqm

3OPE | pdb_00003ope

4YNM | pdb_00004ynm

4YNP | pdb_00004ynp

4YPA | pdb_00004ypa

4YPE | pdb_00004ype

4YPU | pdb_00004ypu

6AGO | pdb_00006ago

6INE | pdb_00006ine

6WZW | pdb_00006wzw

6X0P | pdb_00006x0p

7Y0I | pdb_00007y0i

8VLH | pdb_00008vlh