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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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MyPDB

QUERY: Gene Name = "MCL1"

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Search Summary

This query matches 135 Structures.

Refinements

Structure Determination Methodology

experimental (135)

Scientific Name of Source Organism

	Homo sapiens (130)
	Mus musculus (12)
	Escherichia coli K-12 (11)
	synthetic construct (11)
	Escherichia coli O157:H7 (8)
	Escherichia coli (6)
	Serratia sp. FS14 (6)
	Cereibacter sphaeroides 2.4.1 (2)
	saltans group (1)

Taxonomy

	Eukaryota (133)
	Bacteria (33)
	other sequences (11)
	Eukaryota (eukaryotes) (1)

Experimental Method

	X-RAY DIFFRACTION (131)
	SOLUTION NMR (4)

Polymer Entity Type

Protein (135)

Refinement Resolution (Å)

	1.0 - 1.5 (9)
	1.5 - 2.0 (51)
	2.0 - 2.5 (51)
	2.5 - 3.0 (20)

Release Date

	2005 - 2009 (7)
	2010 - 2014 (18)
	2015 - 2019 (71)
	2020 - 2024 (35)
	2025 - 2029 (4)

Enzyme Classification Name

	Lyases (2)
	Hydrolases (1)
	Transferases (1)

Symmetry Type

	Asymmetric (132)
	Cyclic (11)
	Dihedral (6)

SCOP Classification

	Membrane and cell surface proteins and peptides (71)
	Artifacts (35)
	All beta proteins (7)

AllSelected

1 to 25 of 135 Structures

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2JM6 \| pdb_00002jm6	Download File View File

Solution structure of MCL-1 complexed with NOXAB

Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.

(2007) Proc Natl Acad Sci U S A 104: 6217-6222

Released	2007-03-20
Method	SOLUTION NMR
Organisms	Mus musculus
Macromolecule	Myeloid cell leukemia-1 protein Mcl-1 homolog (protein) Noxa (protein)

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2KBW \| pdb_00002kbw	Download File View File

Solution Structure of human Mcl-1 complexed with human Bid_BH3 peptide

Liu, Q., Moldoveanu, T., Sprules, T., Matta-Camacho, E., Mansur-Azzam, N., Gehring, K.

(2010) J Biological Chem 285: 19615-19624

Released	2009-12-15
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	BH3-interacting domain death agonist (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)

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2MHS \| pdb_00002mhs	Download File View File

NMR Structure of human Mcl-1

Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.

(2014) PLoS One 9: e96521-e96521

Released	2014-05-14
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)

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2NL9 \| pdb_00002nl9	Download File View File

Crystal structure of the Mcl-1:Bim BH3 complex

Czabotar, P.E., Colman, P.M.

(2007) Proc Natl Acad Sci U S A 104: 6217-6222

Released	2007-03-27
Method	X-RAY DIFFRACTION 1.55 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Bcl-2-like protein 11 (protein) FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (protein)
Unique Ligands	CL, ZN

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2NLA \| pdb_00002nla	Download File View File

Crystal structure of the Mcl-1:mNoxaB BH3 complex

Czabotar, P.E., Colman, P.M.

(2007) Proc Natl Acad Sci U S A 104: 6217-6222

Released	2007-03-27
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (protein) Phorbol-12-myristate-13-acetate-induced protein 1 (protein)

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2PQK \| pdb_00002pqk	Download File View File

X-ray crystal structure of human Mcl-1 in complex with Bim BH3

Bare, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2007-06-19
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Bim BH3 peptide (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	NA, ZN

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3D7V \| pdb_00003d7v	Download File View File

Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand

Lee, E.F., Czabotar, P.E., Colman, P.M., Fairlie, W.D.

(2008) J Cell Biol 180: 341-355

Released	2008-06-24
Method	X-RAY DIFFRACTION 2.03 Å
Organisms	Homo sapiens Mus musculus synthetic construct
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ZN

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3IO9 \| pdb_00003io9	Download File View File

BimL12Y in complex with Mcl-1

Czabotar, P.E., Lee, E.F., Yang, H., Sleebs, B.E., Lessene, G., Colman, P.M., Smith, B.J., Fairlie, W.D.

(2009) J Biological Chem 284: 30508-30517

Released	2009-09-01
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ZN

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3KJ0 \| pdb_00003kj0	Download File View File

Mcl-1 in complex with Bim BH3 mutant I2dY

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	TRS

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3KJ1 \| pdb_00003kj1	Download File View File

Mcl-1 in complex with Bim BH3 mutant I2dA

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 1.945 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ACT, CL, ZN

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3KJ2 \| pdb_00003kj2	Download File View File

Mcl-1 in complex with Bim BH3 mutant F4aE

Fire, E., Grant, R.A., Keating, A.E.

(2010) Protein Sci 19: 507-519

Released	2010-02-16
Method	X-RAY DIFFRACTION 2.351 Å
Organisms	Homo sapiens
Macromolecule	Bcl-2-like protein 11 (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	ACT, ZN

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3KZ0 \| pdb_00003kz0	Download File View File

MCL-1 complex with MCL-1-specific selected peptide

Dutta, S., Fire, E., Grant, R.A., Sauer, R.T., Keating, A.E.

(2010) J Mol Biology 398: 747-762

Released	2010-05-05
Method	X-RAY DIFFRACTION 2.349 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein) Mcl-1 specific peptide MB7 (protein)
Unique Ligands	SO4, ZN

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3MK8 \| pdb_00003mk8	Download File View File

The MCL-1 BH3 Helix is an Exclusive MCL-1 Inhibitor and Apoptosis Sensitizer

Stewart, M., Fire, E., Keating, A.E., Walensky, L.D.

(2010) Nat Chem Biol 6: 595-601

Released	2010-06-23
Method	X-RAY DIFFRACTION 2.321 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)

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3PK1 \| pdb_00003pk1	Download File View File

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Czabotar, P.E., Colman, P.M.

(2011) J Biological Chem 286: 7123-7131

Released	2010-12-29
Method	X-RAY DIFFRACTION 2.486 Å
Organisms	Homo sapiens
Macromolecule	Apoptosis regulator BAX (protein) Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	CD

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3WIX \| pdb_00003wix	Download File View File

Crystal structure of Mcl-1 in complex with compound 4

Sogabe, S., Igaki, S., Hayano, Y.

(2013) J Med Chem 56: 9635-9645

Released	2013-11-27
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LC3

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3WIY \| pdb_00003wiy	Download File View File

Crystal structure of Mcl-1 in complex with compound 10

Sogabe, S., Igaki, S., Hayano, Y.

(2013) J Med Chem 56: 9635-9645

Released	2013-11-27
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	LC6

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4G35 \| pdb_00004g35	Download File View File

Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.

Drake, E., Edwardraja, S., Lin, Q., Gulick, A.M.

(2012) J Am Chem Soc 134: 14734-14737

Released	2012-12-05
Method	X-RAY DIFFRACTION 2 Å
Organisms	Mus musculus
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (protein) Noxa BH3 peptide (cysteine-mediated cross-linked) (protein)
Unique Ligands	4BP

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4HW2 \| pdb_00004hw2	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	19H, EDO, PGE

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4HW3 \| pdb_00004hw3	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	19G

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4HW4 \| pdb_00004hw4	Download File View File

Discovery of potent Mcl-1 inhibitors using fragment-based methods and structure-based design

Friberg, A., Zhao, B.

(2013) J Med Chem 56: 15-30

Released	2013-01-09
Method	X-RAY DIFFRACTION 1.53 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein) Mcl-1 BH3 peptide (protein)

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4L9Y \| pdb_00004l9y	Download File View File

Crystal Structure of Rhodobacter sphaeroides malyl-CoA lyase in complex with magnesium, glyoxylate, and propionyl-CoA

Zarzycki, J., Kerfeld, C.A.

(2013) BMC Struct Biol 13: 28-28

Released	2013-12-04
Method	X-RAY DIFFRACTION 2.102 Å
Organisms	Cereibacter sphaeroides 2.4.1
Macromolecule	Malyl-CoA lyase (protein)
Unique Ligands	1VU, CL, GLV, MG

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4L9Z \| pdb_00004l9z	Download File View File

Crystal Structure of Rhodobacter sphaeroides malyl-CoA lyase in complex with magnesium, oxalate, and CoA

Zarzycki, J., Kerfeld, C.A.

(2013) BMC Struct Biol 13: 28-28

Released	2013-12-04
Method	X-RAY DIFFRACTION 2.011 Å
Organisms	Cereibacter sphaeroides 2.4.1
Macromolecule	Malyl-CoA lyase (protein)
Unique Ligands	COA, MG, OXL

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4OQ5 \| pdb_00004oq5	Download File View File

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.

(2014) Bioorg Med Chem Lett 24: 1484-1488

Released	2014-03-12
Method	X-RAY DIFFRACTION 2.86 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	2UU

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4OQ6 \| pdb_00004oq6	Download File View File

Crystal Structure of Human MCL-1 Bound to Inhibitor 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid

Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.

(2014) Bioorg Med Chem Lett 24: 1484-1488

Released	2014-03-12
Method	X-RAY DIFFRACTION 1.81 Å
Organisms	Homo sapiens
Macromolecule	Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	2UV

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4WGI \| pdb_00004wgi	Download File View File

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

Clifton, M.C., Fairman, J.W., Fang, C., D'Souza, B., Fulroth, B., Leed, A., McCarren, P., Wang, L., Wang, Y., Kaushik, V., Palmer, M., Wei, G., Golub, T.R., Hubbard, B.K., Serrano-Wu, M.H.

(2014) ACS Med Chem Lett 5: 1308-1312

Released	2014-11-19
Method	X-RAY DIFFRACTION 1.85 Å
Organisms	Escherichia coli O157:H7 Homo sapiens
Macromolecule	Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1 (protein)
Unique Ligands	3M6, FMT, MG
Unique branched monosaccharides	GLC

1 to 25 of 135 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

2JM6 | pdb_00002jm6

2KBW | pdb_00002kbw

2MHS | pdb_00002mhs

2NL9 | pdb_00002nl9

2NLA | pdb_00002nla

2PQK | pdb_00002pqk

3D7V | pdb_00003d7v

3IO9 | pdb_00003io9

3KJ0 | pdb_00003kj0

3KJ1 | pdb_00003kj1

3KJ2 | pdb_00003kj2

3KZ0 | pdb_00003kz0

3MK8 | pdb_00003mk8

3PK1 | pdb_00003pk1

3WIX | pdb_00003wix

3WIY | pdb_00003wiy

4G35 | pdb_00004g35

4HW2 | pdb_00004hw2

4HW3 | pdb_00004hw3

4HW4 | pdb_00004hw4

4L9Y | pdb_00004l9y

4L9Z | pdb_00004l9z

4OQ5 | pdb_00004oq5

4OQ6 | pdb_00004oq6

4WGI | pdb_00004wgi