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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Gene Name = "PIM1"

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Search Summary

This query matches 168 Structures.

Refinements

Structure Determination Methodology

experimental (168)

Scientific Name of Source Organism

	Homo sapiens (167)
	synthetic construct (15)
	Escherichia coli (2)
	Saccharomyces cerevisiae S288C (1)

Taxonomy

	Eukaryota (168)
	other sequences (15)
	Bacteria (2)

Experimental Method

	X-RAY DIFFRACTION (167)
	ELECTRON MICROSCOPY (1)

Polymer Entity Type

Protein (168)

Refinement Resolution (Å)

	1.5 - 2.0 (36)
	2.0 - 2.5 (100)
	2.5 - 3.0 (28)
	3.0 - 3.5 (4)

Release Date

	2000 - 2004 (2)
	2005 - 2009 (28)
	2010 - 2014 (38)
	2015 - 2019 (65)
	2020 - 2024 (35)

Enzyme Classification Name

	Transferases (167)
	Hydrolases (1)

Symmetry Type

Asymmetric (168)

SCOP Classification

Alpha and beta proteins (a+b) (117)

AllSelected

1 to 25 of 168 Structures

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Explore in 3D

1XQZ \| pdb_00001xqz	Download File View File

Crystal Structure of hPim-1 kinase at 2.1 A resolution

Qian, K.C., Wang, L., Hickey, E.R., Studts, J., Barringer, K., Peng, C., Kronkaitis, A., Li, J., White, A., Mische, S., Farmer, B.

(2005) J Biological Chem 280: 6130-6137

Released	2004-11-09
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)

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1XR1 \| pdb_00001xr1	Download File View File

Crystal structure of hPim-1 kinase in complex with AMP-PNP at 2.1 A Resolution

Qian, K.C., Wang, L., Hickey, E.R., Studts, J., Barringer, K., Peng, C., Kronkaitis, A., Li, J., White, A., Mische, S., Farmer, B.

(2005) J Biological Chem 280: 6130-6137

Released	2004-11-09
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	ANP, MG

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1YHS \| pdb_00001yhs	Download File View File

Crystal structure of Pim-1 bound to staurosporine

Jacobs, M.D., Black, J., Futer, O., Swenson, L., Hare, B., Fleming, M., Saxena, K.

(2005) J Biological Chem 280: 13728-13734

Released	2005-01-25
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	STU

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1YI3 \| pdb_00001yi3	Download File View File

Crystal Structure of Pim-1 bound to LY294002

Jacobs, M.D., Black, J., Futer, O., Swenson, L., Hare, B., Fleming, M., Saxena, K.

(2005) J Biological Chem 280: 13728-13734

Released	2005-01-25
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	LY2

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1YI4 \| pdb_00001yi4	Download File View File

Structure of Pim-1 bound to adenosine

Jacobs, M.D., Black, J., Futer, O., Swenson, L., Hare, B., Fleming, M., Saxena, K.

(2005) J Biological Chem 280: 13728-13734

Released	2005-01-25
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	ADN

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1YWV \| pdb_00001ywv	Download File View File

Crystal Structures of Proto-Oncogene Kinase Pim1: a Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD

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1YXS \| pdb_00001yxs	Download File View File

Crystal Structure of Kinase Pim1 with P123M mutation

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD

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1YXT \| pdb_00001yxt	Download File View File

Crystal Structure of Kinase Pim1 in complex with AMPPNP

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	ANP

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1YXU \| pdb_00001yxu	Download File View File

Crystal Structure of Kinase Pim1 in Complex with AMP

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2.24 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	AMP, IMD

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1YXV \| pdb_00001yxv	Download File View File

Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, LI6

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1YXX \| pdb_00001yxx	Download File View File

Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE

Kumar, A., Mandiyan, V., Suzuki, Y., Zhang, C., Rice, J., Tsai, J., Artis, D.R., Ibrahim, P., Bremer, R.

(2005) J Mol Biology 348: 183-193

Released	2005-04-26
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, LI7

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2O3P \| pdb_00002o3p	Download File View File

Crystal structure of Pim1 with Quercetin

Holder, S., Zemskova, M., Zhang, C., Tabrizizad, M., Bremer, R., Neidigh, J.W., Lilly, M.B.

(2007) Mol Cancer Ther 6: 163-172

Released	2007-02-13
Method	X-RAY DIFFRACTION 2.24 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, QUE

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2O63 \| pdb_00002o63	Download File View File

Crystal structure of Pim1 with Myricetin

Holder, S., Zemskova, M., Zhang, C., Tabrizizad, M., Bremer, R., Neidigh, J.W., Lilly, M.B.

(2007) Mol Cancer Ther 6: 163-172

Released	2007-02-13
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, MYC

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2O64 \| pdb_00002o64	Download File View File

Crystal structure of Pim1 with Quercetagetin

Holder, S., Zemskova, M., Zhang, C., Tabrizizad, M., Bremer, R., Neidigh, J.W., Lilly, M.B.

(2007) Mol Cancer Ther 6: 163-172

Released	2007-02-13
Method	X-RAY DIFFRACTION 2.44 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, MYU

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2O65 \| pdb_00002o65	Download File View File

Crystal structure of Pim1 with Pentahydroxyflavone

Holder, S., Zemskova, M., Zhang, C., Tabrizizad, M., Bremer, R., Neidigh, J.W., Lilly, M.B.

(2007) Mol Cancer Ther 6: 163-172

Released	2007-02-13
Method	X-RAY DIFFRACTION 2.85 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	IMD, MYF

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2OI4 \| pdb_00002oi4	Download File View File

Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole

Maksimoska, J., Meggers, E.

(2007) Org Biomol Chem 5: 1218-1227

Released	2007-04-10
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	CL, EDO, EPE, JM1

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2XJ2 \| pdb_00002xj2	Download File View File

Protein kinase Pim-1 in complex with small molecule inhibitor

Schulz, M.N., Fanghanel, J., Schafer, M., Badock, V., Briem, H., Boemer, U., Nguyen, D., Husemann, M., Hillig, R.C.

(2011) Acta Crystallogr D Biol Crystallogr 67: 156

Released	2011-02-23
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Homo sapiens
Macromolecule	PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 (protein)
Unique Ligands	985

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3A99 \| pdb_00003a99	Download File View File

Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide

Morishita, D., Takami, M., Yoshikawa, S., Katayama, R., Sato, S., Kukimoto-Niino, M., Umehara, T., Shirouzu, M., Sekimizu, K., Yokoyama, S., Fujita, N.

(2011) J Biological Chem 286: 2681-2688

Released	2010-11-03
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase pim-1 (protein)
Unique Ligands	ANP, MG

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3BGP \| pdb_00003bgp	Download File View File

Human Pim-1 complexed with a benzoisoxazole inhibitor VX1

Jacobs, M.D.

(2008) J Med Chem 51: 1972-1975

Released	2007-12-11
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	VX1

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3BGQ \| pdb_00003bgq	Download File View File

Human Pim-1 kinase in complex with an triazolo pyridazine inhibitor VX2

Jacobs, M.D.

(2008) J Med Chem 51: 1972-1975

Released	2007-12-11
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	VX2

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3BGZ \| pdb_00003bgz	Download File View File

Human Pim-1 kinase in complex with diphenyl indole inhibitor VX3

Jacobs, M.D.

(2008) J Med Chem 51: 1972-1975

Released	2007-12-11
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	VX3

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3BWF \| pdb_00003bwf	Download File View File

Crystal structure of the human Pim1 in complex with an osmium compound

Maksimoska, J., Filippakopoulos, P., Knapp, S., Meggers, E.

(2008) Chemistry 14: 4816-4822

Released	2008-06-24
Method	X-RAY DIFFRACTION 2.35 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	DWC, SO4

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3C4E \| pdb_00003c4e	Download File View File

Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole

Zhang, K.Y.J., Wang, W.

(2008) Proc Natl Acad Sci U S A 105: 3041-3046

Released	2008-02-26
Method	X-RAY DIFFRACTION 1.98 Å
Organisms	Homo sapiens
Macromolecule	Proto-oncogene serine/threonine-protein kinase Pim-1 (protein)
Unique Ligands	C4E, IMD

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3CXW \| pdb_00003cxw	Download File View File

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand I

Filippakopoulos, P., Bullock, A., Fedorov, O., Huber, K., Bracher, F., Pike, A.C.W., Roos, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 403-413

Released	2008-07-15
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Homo sapiens
Macromolecule	Pimtide peptide (protein) Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2 (protein)
Unique Ligands	7CP, CL

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3CY2 \| pdb_00003cy2	Download File View File

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II

Filippakopoulos, P., Bullock, A., Fedorov, O., Huber, K., Bracher, F., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) J Med Chem 55: 403-413

Released	2008-07-15
Method	X-RAY DIFFRACTION 2.01 Å
Organisms	Homo sapiens
Macromolecule	Pimtide peptide (protein) Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2 (protein)
Unique Ligands	CL, EDO, MB9

1 to 25 of 168 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1XQZ | pdb_00001xqz

1XR1 | pdb_00001xr1

1YHS | pdb_00001yhs

1YI3 | pdb_00001yi3

1YI4 | pdb_00001yi4

1YWV | pdb_00001ywv

1YXS | pdb_00001yxs

1YXT | pdb_00001yxt

1YXU | pdb_00001yxu

1YXV | pdb_00001yxv

1YXX | pdb_00001yxx

2O3P | pdb_00002o3p

2O63 | pdb_00002o63

2O64 | pdb_00002o64

2O65 | pdb_00002o65

2OI4 | pdb_00002oi4

2XJ2 | pdb_00002xj2

3A99 | pdb_00003a99

3BGP | pdb_00003bgp

3BGQ | pdb_00003bgq

3BGZ | pdb_00003bgz

3BWF | pdb_00003bwf

3C4E | pdb_00003c4e

3CXW | pdb_00003cxw

3CY2 | pdb_00003cy2