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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 2.1.1.367

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Search Summary

This query matches 89 Structures.

Refinements

Structure Determination Methodology

experimental (89)

Scientific Name of Source Organism

	Homo sapiens (71)
	Arabidopsis thaliana (11)
	Mus musculus (3)
	Schizosaccharomyces pombe (3)
	Schizosaccharomyces pombe 972h- (3)
	synthetic construct (3)
	Xenopus laevis (1)

Taxonomy

	Eukaryota (89)
	other sequences (3)
	Eukaryota (eukaryotes) (2)

Experimental Method

	X-RAY DIFFRACTION (85)
	SOLUTION NMR (4)

Polymer Entity Type

	Protein (89)
	DNA (9)

Refinement Resolution (Å)

	1.0 - 1.5 (5)
	1.5 - 2.0 (32)
	2.0 - 2.5 (27)
	2.5 - 3.0 (16)
	3.0 - 3.5 (5)

Release Date

	2000 - 2004 (3)
	2005 - 2009 (9)
	2010 - 2014 (17)
	2015 - 2019 (36)
	2020 - 2024 (17)
	2025 - 2029 (7)

Enzyme Classification Name

Transferases (89)

Symmetry Type

	Asymmetric (50)
	Cyclic (48)

SCOP Classification

	All beta proteins (29)
	Artifacts (6)
	Alpha and beta proteins (a+b) (2)
	All alpha proteins (1)
	Membrane and cell surface proteins and peptides (1)

AllSelected

1 to 25 of 89 Structures

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1G6Z \| pdb_00001g6z	Download File View File

SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN

Horita, D.A., Ivanova, A.V., Altieri, A.S., Klar, A.J., Byrd, R.A.

(2001) J Mol Biology 307: 861-870

Released	2001-04-04
Method	SOLUTION NMR
Organisms	Schizosaccharomyces pombe
Macromolecule	CLR4 PROTEIN (protein)

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1MVH \| pdb_00001mvh	Download File View File

structure of the SET domain histone lysine methyltransferase Clr4

Min, J.R., Zhang, X., Cheng, X.D., Grewal, S.I.S., Xu, R.-M.

(2002) Nat Struct Biol 9: 828-832

Released	2002-10-30
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Schizosaccharomyces pombe
Macromolecule	Cryptic loci regulator 4 (protein)
Unique Ligands	NI, SO4, ZN

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1MVX \| pdb_00001mvx	Download File View File

structure of the SET domain histone lysine methyltransferase Clr4

Min, J.R., Zhang, X., Cheng, X.D., Grewal, S.I.S., Xu, R.-M.

(2002) Nat Struct Biol 9: 828-832

Released	2002-10-30
Method	X-RAY DIFFRACTION 3 Å
Organisms	Schizosaccharomyces pombe
Macromolecule	CRYPTIC LOCI REGULATOR 4 (protein)
Unique Ligands	NI, SO4, ZN

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2IGQ \| pdb_00002igq	Download File View File

Human euchromatic histone methyltransferase 1

Min, J., Wu, H., Antoshenko, T., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)

(2010) PLoS One 5: e8570-e8570

Released	2006-10-24
Method	X-RAY DIFFRACTION 2 Å
Organisms	Homo sapiens
Macromolecule	euchromatic histone methyltransferase 1 (protein)
Unique Ligands	SAH, ZN

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2N1I \| pdb_00002n1i	Download File View File

Structure of the PR domain from PRDM16

Sun, Y., Armstrong, G., Briknarova, K.

To be published

Released	2016-07-06
Method	SOLUTION NMR
Organisms	Homo sapiens
Macromolecule	PR domain zinc finger protein 16 (protein)

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2O8J \| pdb_00002o8j	Download File View File

Human euchromatic histone methyltransferase 2

Min, J., Wu, H., Antoshenko, T., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)

(2010) PLoS One 5: e8570-e8570

Released	2007-01-16
Method	X-RAY DIFFRACTION 1.8 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (protein)
Unique Ligands	SAH, ZN

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2RFI \| pdb_00002rfi	Download File View File

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide

Min, J., Wu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)

(2010) PLoS One 5: e8570-e8570

Released	2007-10-23
Method	X-RAY DIFFRACTION 1.59 Å
Organisms	Homo sapiens
Macromolecule	Histone H3 (protein) Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein)
Unique Ligands	SAH, ZN

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3B7B \| pdb_00003b7b	Download File View File

EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 1)

Collins, R.E., Horton, J.R., Cheng, X.

(2008) Nat Struct Mol Biol 15: 245-250

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.99 Å
Organisms	Homo sapiens
Macromolecule	Euchromatic histone-lysine N-methyltransferase 1 (protein)
Unique Ligands	SO4

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3B95 \| pdb_00003b95	Download File View File

EuHMT1 (Glp) Ankyrin Repeat Domain (Structure 2)

Collins, R.E., Horton, J.R., Cheng, X.

(2008) Nat Struct Mol Biol 15: 245-250

Released	2008-02-12
Method	X-RAY DIFFRACTION 2.99 Å
Organisms	Homo sapiens
Macromolecule	Euchromatic histone-lysine N-methyltransferase 1 (protein) Histone H3 N-terminal Peptide (protein)
Unique Ligands	SO4

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3DM1 \| pdb_00003dm1	Download File View File

Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide

Amaya, M.F., Ravichandran, M., Loppnau, P., Kozieradzki, I., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Bountra, C., Bochkarev, A., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)

(2012) PLoS One 7: e35376-e35376

Released	2008-08-19
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Chromobox protein homolog 3 (protein) Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (protein)

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3FPD \| pdb_00003fpd	Download File View File

G9a-like protein lysine methyltransferase inhibition by BIX-01294

Chang, Y., Zhang, X., Horton, J.R., Cheng, X.

(2009) Nat Struct Mol Biol 16: 312-317

Released	2009-02-17
Method	X-RAY DIFFRACTION 2.4 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein)
Unique Ligands	Q4A, SAH, ZN

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3HNA \| pdb_00003hna	Download File View File

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide

Min, J., Wu, H., Loppnau, P., Wleigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)

(2010) PLoS One 5: e8570-e8570

Released	2009-06-09
Method	X-RAY DIFFRACTION 1.5 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein) Mono-Methylated H3K9 Peptide (protein)
Unique Ligands	SAH, ZN

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3K5K \| pdb_00003k5k	Download File View File

Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a

Dong, A., Wasney, G.A., Liu, F., Chen, X., Allali-Hassani, A., Senisterra, G., Chau, I., Bountra, C., Weigelt, J., Edwards, A.M., Arrowsmith, C.H., Frye, S.V., Bochkarev, A., Brown, P.J., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)

(2009) J Med Chem 52: 7950-7953

Released	2009-11-10
Method	X-RAY DIFFRACTION 1.7 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (protein)
Unique Ligands	CL, DXQ, SAH, UNX, ZN

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3MO0 \| pdb_00003mo0	Download File View File

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11

Chang, Y., Horton, J.R., Cheng, X.

(2010) J Mol Biology 400: 1-7

Released	2010-06-30
Method	X-RAY DIFFRACTION 2.78 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein)
Unique Ligands	E11, EDO, SAH, ZN

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3MO2 \| pdb_00003mo2	Download File View File

human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67

Chang, Y., Horton, J.R., Cheng, X.

(2010) J Mol Biology 400: 1-7

Released	2010-06-30
Method	X-RAY DIFFRACTION 2.49 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein)
Unique Ligands	E67, SAH, ZN

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3MO5 \| pdb_00003mo5	Download File View File

Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72

Chang, Y., Horton, J.R., Cheng, X.

(2010) J Mol Biology 400: 1-7

Released	2010-06-30
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (protein)
Unique Ligands	E72, SAH, ZN

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3MQM \| pdb_00003mqm	Download File View File

Crystal Structure of the Bromodomain of human ASH1L

Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Vollmar, M., Chaikuad, A., Krojer, T., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

(2012) Cell 149: 214-231

Released	2010-05-19
Method	X-RAY DIFFRACTION 2.54 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)

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3OPE \| pdb_00003ope	Download File View File

Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase

An, S., Song, J.

(2011) J Biological Chem 286: 8369-8374

Released	2011-01-12
Method	X-RAY DIFFRACTION 2.9 Å
Organisms	Homo sapiens
Macromolecule	Probable histone-lysine N-methyltransferase ASH1L (protein)
Unique Ligands	SAM, ZN

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3Q0B \| pdb_00003q0b	Download File View File

Crystal structure of SUVH5 SRA- fully methylated CG DNA complex in space group P42212

Eerappa, R., Simanshu, D.K., Patel, D.J.

(2011) Genes Dev 25: 137-152

Released	2011-02-02
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Arabidopsis thaliana
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (protein) DNA (5'-D(APCPTPAP(5CM)PGPTPAPGPT)-3') (nucleic acid)

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3Q0C \| pdb_00003q0c	Download File View File

Crystal structure of SUVH5 SRA-fully methylated CG DNA complex in space group P6122

Eerappa, R., Simanshu, D.K., Patel, D.J.

(2011) Genes Dev 25: 137-152

Released	2011-02-02
Method	X-RAY DIFFRACTION 2.6567 Å
Organisms	Arabidopsis thaliana
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (protein) DNA (5'-D(APCPTPAP(5CM)PGPTPAPGPTP*T)-3') (nucleic acid)
Unique Ligands	MG

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3Q0D \| pdb_00003q0d	Download File View File

Crystal structure of SUVH5 SRA- hemi methylated CG DNA complex

Eerappa, R., Simanshu, D.K., Patel, D.J.

(2011) Genes Dev 25: 137-152

Released	2011-02-23
Method	X-RAY DIFFRACTION 2.3704 Å
Organisms	Arabidopsis thaliana
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (protein) DNA (5'-D(CPTPGPAPCPGPTPGPGPA)-3') (nucleic acid) DNA (5'-D(TPCPCPAP(5CM)PGPTPCPAPG)-3') (nucleic acid)
Unique Ligands	CL

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3Q0F \| pdb_00003q0f	Download File View File

Crystal structure of SUVH5 SRA- methylated CHH DNA complex

Eerappa, R., Simanshu, D.K., Patel, D.J.

(2011) Genes Dev 25: 137-152

Released	2011-02-02
Method	X-RAY DIFFRACTION 2.75 Å
Organisms	Arabidopsis thaliana
Macromolecule	Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (protein) DNA (5'-D(CPTPGPAPGPGPAPGPTPAPT)-3') (nucleic acid) DNA (5'-D(TPAPCPTP(5CM)PCPTPCPAP*G)-3') (nucleic acid)

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3RJW \| pdb_00003rjw	Download File View File

Crystal structure of histone lysine methyltransferase g9a with an inhibitor

Dong, A., Wasney, G.A., Tempel, W., Liu, F., Barsyte, D., Allali-Hassani, A., Chen, X., Chau, I., Hajian, T., Senisterra, G., Chavda, N., Arora, K., Siarheyeva, A., Kireev, D.B., Herold, J.M., Bochkarev, A., Bountra, C., Weigelt, J., Edwards, A.M., Frye, S.V., Arrowsmith, C.H., Brown, P.J., Jin, J., Vedadi, M., Structural Genomics Consortium (SGC)

(2011) Nat Chem Biol 7: 566-574

Released	2011-05-04
Method	X-RAY DIFFRACTION 2.56 Å
Organisms	Homo sapiens
Macromolecule	Histone-lysine N-methyltransferase EHMT2 (protein)
Unique Ligands	CIQ, SAH, UNX, ZN

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3SW9 \| pdb_00003sw9	Download File View File

GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide

Chang, Y., Horton, J.R., Zhang, X., Cheng, X.

(2011) Nat Commun 2: 533-533

Released	2011-12-07
Method	X-RAY DIFFRACTION 3.05 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	DNA (cytosine-5)-methyltransferase 3A (protein) Histone-lysine N-methyltransferase EHMT1 (protein)
Unique Ligands	SFG, ZN

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3SWC \| pdb_00003swc	Download File View File

GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide

Chang, Y., Horton, J.R., Zhang, X., Cheng, X.

(2011) Nat Commun 2: 533-533

Released	2011-11-30
Method	X-RAY DIFFRACTION 2.332 Å
Organisms	Homo sapiens Mus musculus
Macromolecule	DNA (cytosine-5)-methyltransferase 3A (protein) Histone-lysine N-methyltransferase EHMT1 (protein)
Unique Ligands	SAH, ZN

1 to 25 of 89 Structures

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1G6Z | pdb_00001g6z

1MVH | pdb_00001mvh

1MVX | pdb_00001mvx

2IGQ | pdb_00002igq

2N1I | pdb_00002n1i

2O8J | pdb_00002o8j

2RFI | pdb_00002rfi

3B7B | pdb_00003b7b

3B95 | pdb_00003b95

3DM1 | pdb_00003dm1

3FPD | pdb_00003fpd

3HNA | pdb_00003hna

3K5K | pdb_00003k5k

3MO0 | pdb_00003mo0

3MO2 | pdb_00003mo2

3MO5 | pdb_00003mo5

3MQM | pdb_00003mqm

3OPE | pdb_00003ope

3Q0B | pdb_00003q0b

3Q0C | pdb_00003q0c

3Q0D | pdb_00003q0d

3Q0F | pdb_00003q0f

3RJW | pdb_00003rjw

3SW9 | pdb_00003sw9

3SWC | pdb_00003swc