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233,605 Structures from the PDB

1,068,577 Computed Structure Models (CSM)

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QUERY: Enzyme Classification Number = 3.4.22.68

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This query matches 12 Structures.

Refinements

Structure Determination Methodology

experimental (12)

Scientific Name of Source Organism

	Saccharomyces cerevisiae S288C (5)
	Saccharomyces cerevisiae (4)
	Homo sapiens (2)
	Thermochaetoides thermophila (1)

Taxonomy

Eukaryota (12)

Experimental Method

X-RAY DIFFRACTION (12)

Polymer Entity Type

Protein (12)

Refinement Resolution (Å)

	1.0 - 1.5 (1)
	1.5 - 2.0 (2)
	2.0 - 2.5 (6)
	2.5 - 3.0 (2)
	3.0 - 3.5 (1)

Release Date

	2000 - 2004 (1)
	2005 - 2009 (3)
	2010 - 2014 (1)
	2015 - 2019 (7)

Enzyme Classification Name

Hydrolases (12)

Symmetry Type

	Asymmetric (11)
	Cyclic (1)

SCOP Classification

	Alpha and beta proteins (a+b) (6)
	Artifacts (5)
	All alpha proteins (2)

AllSelected

1 to 12 of 12 Structures

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1EUV \| pdb_00001euv	Download File View File

X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.

Mossessova, E., Lima, C.D.

(2000) Mol Cell 5: 865-876

Released	2000-06-07
Method	X-RAY DIFFRACTION 1.6 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	UBITQUTIN-LIKE PROTEIN SMT3 (protein) ULP1 PROTEASE (protein)

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2HKP \| pdb_00002hkp	Download File View File

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfenic acid

Xu, Z., Ng, T.B., Au, S.W.N.

(2008) FASEB J 22: 127-137

Released	2007-07-31
Method	X-RAY DIFFRACTION 2.1 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Ubiquitin-like-specific protease 1 (protein)

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2HL8 \| pdb_00002hl8	Download File View File

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfinic acid

Xu, Z., Ng, T.B., Au, S.W.N.

(2008) FASEB J 22: 127-137

Released	2007-07-31
Method	X-RAY DIFFRACTION 2 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Ubiquitin-like-specific protease 1 (protein)

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2HL9 \| pdb_00002hl9	Download File View File

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfonic acid

Xu, Z., Ng, T.B., Au, S.W.N.

(2008) FASEB J 22: 127-137

Released	2007-07-31
Method	X-RAY DIFFRACTION 1.9 Å
Organisms	Saccharomyces cerevisiae
Macromolecule	Ubiquitin-like-specific protease 1 (protein)

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3ZO5 \| pdb_00003zo5	Download File View File

Structure of SENP2-Loop1 in complex with preSUMO-2

Alegre, K.O., Reverter, D.

(2014) Protein Sci 23: 433

Released	2014-01-29
Method	X-RAY DIFFRACTION 2.15 Å
Organisms	Homo sapiens
Macromolecule	SENTRIN-SPECIFIC PROTEASE 2 (protein) SMALL UBIQUITIN-RELATED MODIFIER 2 (protein)

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5AEK \| pdb_00005aek	Download File View File

Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W

Gallego, P., Grana-Montes, R., Espargaro, A., Castillo, V., Torrent, J., Lange, R., Papaleo, E., Lindorff-Larsend, K., Ventura, S., Reverter, D.

To be published

Released	2016-01-20
Method	X-RAY DIFFRACTION 3 Å
Organisms	Homo sapiens
Macromolecule	SENTRIN-SPECIFIC PROTEASE 2 (protein) SMALL UBIQUITIN-RELATED MODIFIER 1 (protein)

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5H2V \| pdb_00005h2v	Download File View File

Crystal structure of the karyopherin Kap121p bound to the SUMO protease Ulp1p

Kobayashi, J., Matsuura, Y.

(2017) J Mol Biology 429: 249-260

Released	2016-12-14
Method	X-RAY DIFFRACTION 2.8 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Importin subunit beta-3 (protein) Ubiquitin-like-specific protease 1 (protein)

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5H2W \| pdb_00005h2w	Download File View File

Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)

Hirano, H., Matsuura, Y.

(2017) J Mol Biology 429: 249-260

Released	2016-12-14
Method	X-RAY DIFFRACTION 2.5 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Importin subunit alpha (protein) Ubiquitin-like-specific protease 1 (protein)

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5H2X \| pdb_00005h2x	Download File View File

Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172)

Hirano, H., Matsuura, Y.

(2017) J Mol Biology 429: 249-260

Released	2016-12-14
Method	X-RAY DIFFRACTION 2.2 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Importin subunit alpha (protein) Ubiquitin-like-specific protease 1 (protein)

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5LNB \| pdb_00005lnb	Download File View File

Crystal structure of the de-sumoylating protease

Eckhoff, J., Dohmen, J., Pichlo, C., Baumann, U.

To be published

Released	2017-08-16
Method	X-RAY DIFFRACTION 2.3 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Ubiquitin-like-specific protease 2 (protein)
Unique Ligands	ACT

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5V1A \| pdb_00005v1a	Download File View File

Structure of S. cerevisiae Ulp2:Csm1 complex

Singh, N., Corbett, K.D.

(2017) Genes Dev 31: 802-815

Released	2017-05-17
Method	X-RAY DIFFRACTION 2.14 Å
Organisms	Saccharomyces cerevisiae S288C
Macromolecule	Monopolin complex subunit CSM1 (protein) Ubiquitin-like-specific protease 2 (protein)

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6DG4 \| pdb_00006dg4	Download File View File

Structure of the Chaetomium thermophilum Ulp1-like SUMO protease catalytic domain

Lima, C.D., Baytshtok, V.

(2018) J Biological Chem 293: 13224-13233

Released	2018-07-11
Method	X-RAY DIFFRACTION 1.442 Å
Organisms	Thermochaetoides thermophila
Macromolecule	Ulp1-like SUMO protease (protein)
Unique Ligands	GOL, SO4

1 to 12 of 12 Structures

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RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

1EUV | pdb_00001euv

X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.

2HKP | pdb_00002hkp

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfenic acid

2HL8 | pdb_00002hl8

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfinic acid

2HL9 | pdb_00002hl9

SUMO protease Ulp1 with the catalytic cysteine oxidized to a sulfonic acid

3ZO5 | pdb_00003zo5

Structure of SENP2-Loop1 in complex with preSUMO-2

5AEK | pdb_00005aek

Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W

5H2V | pdb_00005h2v

Crystal structure of the karyopherin Kap121p bound to the SUMO protease Ulp1p

5H2W | pdb_00005h2w

Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-340)

5H2X | pdb_00005h2x

Crystal structure of the karyopherin Kap60p bound to the SUMO protease Ulp1p (150-172)

5LNB | pdb_00005lnb

Crystal structure of the de-sumoylating protease

5V1A | pdb_00005v1a

Structure of S. cerevisiae Ulp2:Csm1 complex

6DG4 | pdb_00006dg4

Structure of the Chaetomium thermophilum Ulp1-like SUMO protease catalytic domain

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Structure Determination Methodology

Scientific Name of Source Organism

Taxonomy

Experimental Method

Polymer Entity Type

Refinement Resolution (Å)

Release Date

Enzyme Classification Name

Symmetry Type

SCOP Classification

1EUV | pdb_00001euv

2HKP | pdb_00002hkp

2HL8 | pdb_00002hl8

2HL9 | pdb_00002hl9

3ZO5 | pdb_00003zo5

5AEK | pdb_00005aek

5H2V | pdb_00005h2v

5H2W | pdb_00005h2w

5H2X | pdb_00005h2x

5LNB | pdb_00005lnb

5V1A | pdb_00005v1a

6DG4 | pdb_00006dg4