2BRH | pdb_00002brh

Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity

CHAIN

A

Serine/threonine-protein kinase Chk1 - Homo sapiens

Explore Sequence Annotations in 3D

CHAIN A

UNIPROT O14757

SECONDARY STRUCTURE

UNMODELED

PLANE OUTLIERS

EDS ATOMS

OCC WT AVG B

AVERAGE OCCUPANCY

ATOMIC CLASHES

ANGLE OUTLIERS

BOND OUTLIERS

RSRZ

RSR

RSCC

CIS-PEPTIDE

BINDING SITE DFW

BURIED RESIDUES

HYDROPATHY

DISORDER

DISORDERED BINDING

PFAM

CATH

SCOP

ECOD

MOLECULE PROCESSING

GENOME VARIANT

CROSS-LINK

ACTIVE SITE

MODIFIED RESIDUE

MUTAGENESIS

CONFLICT

DOMAIN

REGION

COMPOSITIONAL BIAS

SEQUENCE SPLICING

LOADING 52%

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.