4AN2 | pdb_00004an2

Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.

CHAIN

A

Cytochrome c-552 - Thermus thermophilus HB8

Explore Sequence Annotations in 3D

CHAIN A

UNIPROT Q5SME3

SECONDARY STRUCTURE

UNMODELED

ZERO OCCUPANCY ATOM

EDS ATOMS

OCC WT AVG B

AVERAGE OCCUPANCY

ATOMIC CLASHES

ANGLE OUTLIERS

BOND OUTLIERS

RSRZ

RSR

RSCC

BINDING SITE HEC

BINDING SITE HEC

METAL COORDINATION HEC

BURIED RESIDUES

DISULFIDE BRIDGE

COVALENT BOND

HYDROPATHY

DISORDER

DISORDERED BINDING

CATH

SCOP

ECOD

MOLECULE PROCESSING

MODIFIED RESIDUE

LOADING 97%

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.