3CPS

Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase

PDB DOI: https://doi.org/10.2210/pdb3CPS/pdb

Classification: OXIDOREDUCTASE
Organism(s): Cryptosporidium parvum Iowa II
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2008-04-01 Released: 2008-04-15
Deposition Author(s): Wernimont, A.K., Lew, J., Kozieradzki, I., Cossar, D., Schapiro, M., Bochkarev, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Pizarro, J., Hills, T., Structural Genomics Consortium (SGC)

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 1.90 Å
R-Value Free: 0.286
R-Value Work: 0.239
R-Value Observed: 0.242

Starting Model: experimental
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wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.3 of the entry. See complete history.

Literature

Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase.

Wernimont, A.K., Lew, J., Kozieradzki, I., Cossar, D., Schapiro, M., Bochkarev, A., Bountra, C., Weigelt, J., Edwards, A.M., Hui, R., Pizarro, J., Hills, T.

To be published.

Macromolecule Content

Total Structure Weight: 77.45 kDa
Atom Count: 5,422
Modelled Residue Count: 667
Deposited Residue Count: 708
Unique protein chains: 1

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Glyceraldehyde 3-phosphate dehydrogenase	A, B	354	Cryptosporidium parvum Iowa II	Mutation(s): 0 Gene Names: cgd6_3790 EC: 1.2.1.12
UniProt
Find proteins for Q5CWT6 (Cryptosporidium parvum (strain Iowa II)) Explore Q5CWT6 Go to UniProtKB: Q5CWT6
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q5CWT6
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 1 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
NAD Query on NAD Download Ideal Coordinates CCD File SDF format, chain C [auth A] SDF format, chain D [auth B] MOL2 format, chain C [auth A] MOL2 format, chain D [auth B] mmCIF format, chain C [auth A] mmCIF format, chain D [auth B]	C [auth A], D [auth B]	NICOTINAMIDE-ADENINE-DINUCLEOTIDE C₂₁ H₂₇ N₇ O₁₄ P₂ BAWFJGJZGIEFAR-NNYOXOHSSA-N		Interactions Focus chain C [auth A] Focus chain D [auth B] Interactions & Density Focus chain C [auth A] Focus chain D [auth B]

Experimental Data & Validation

Experimental Data

Method: X-RAY DIFFRACTION
Resolution: 1.90 Å
R-Value Free: 0.286
R-Value Work: 0.239
R-Value Observed: 0.242
Space Group: C 1 2 1

Unit Cell:

Length ( Å )	Angle ( ˚ )
a = 80.83	α = 90
b = 135.22	β = 103.8
c = 67.923	γ = 90

Software Package:

Software Name	Purpose
DENZO	data reduction
SCALEPACK	data scaling
PHASER	phasing
REFMAC	refinement
PDB_EXTRACT	data extraction

Structure Validation

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Ligand Structure Quality Assessment

Entry History

Deposition Data

Released Date: 2008-04-15

Deposition Author(s):

Structural Genomics Consortium (SGC)

Revision History (Full details and data files)

Version 1.0: 2008-04-15
Type: Initial release
Version 1.1: 2011-07-13
Changes: Advisory, Version format compliance
Version 1.2: 2017-10-25
Changes: Refinement description
Version 1.3: 2023-08-30
Changes: Data collection, Database references, Derived calculations, Refinement description

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3CPS

Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase

Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase.

Entity ID: 1

UniProt

Entity Groups

Sequence Annotations

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Experimental Data

Structure Validation

Ligand Structure Quality Assessment

Deposition Data

Revision History (Full details and data files)