1BD9

HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bd9a_	All beta proteins	PEBP-like	PEBP-like	Phosphatidylethanolamine binding protein	Phosphatidylethanolamine binding protein, PEBP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1bd9b_	All beta proteins	PEBP-like	PEBP-like	Phosphatidylethanolamine binding protein	Phosphatidylethanolamine binding protein, PEBP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PEBP-like	8036505	3001269	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PEBP-like	8036505	3001269	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PBP	e1bd9A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: PEBP-like	F: PBP	ECOD (1.6)
B	PBP	e1bd9B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: PEBP-like	F: PBP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.280.10	Alpha Beta	Alpha-Beta Complex	Phosphatidylethanolamine-binding Protein	PEBP-like	CATH (4.3.0)
B	3.90.280.10	Alpha Beta	Alpha-Beta Complex	Phosphatidylethanolamine-binding Protein	PEBP-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01161	Phosphatidylethanolamine-binding protein (PBP)	Phosphatidylethanolamine-binding protein	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity phosphatidylethanolamine binding phospholipid binding lipid binding protein binding kinase binding enzyme binding protein kinase binding RNA binding nucleic acid binding	cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication cellular process negative regulation of MAPK cascade negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of protein metabolic process negative regulation of metabolic process negative regulation of molecular function regulation of peptidase activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of hydrolase activity metabolic process macromolecule metabolic process regulation of metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036610	PEBP-like superfamily	Homologous Superfamily
A, B	IPR008914	Phosphatidylethanolamine-binding protein	Family
A, B	IPR001858	Phosphatidylethanolamine-binding, conserved site	Conserved Site
A, B	IPR035810	Phosphatidylethanolamine-binding protein, eukaryotic	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P30086	renal cell carcinoma papillary renal cell carcinoma collecting duct carcinoma sarcomatoid carcinoma chromophobe renal cell carcinoma Mammary Neoplasms, Experimental carcinoma sarcomatoid renal cell carcinoma congestive heart failure pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor undifferentiated carcinoma heart failure mammary neoplasms, animal myocardial ischemia renal cell carcinoma papillary renal cell carcinoma collecting duct carcinoma sarcomatoid carcinoma chromophobe renal cell carcinoma Mammary Neoplasms, Experimental carcinoma sarcomatoid renal cell carcinoma congestive heart failure pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor undifferentiated carcinoma heart failure mammary neoplasms, animal myocardial ischemia pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma psoriasis B-cell chronic lymphocytic leukemia coronary artery disease lung cancer ovarian cancer pancreatic intraductal papillary-mucinous neoplasm precancerous condition astrocytic tumor renal carcinoma clear cell renal carcinoma interstitial cystitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.