1CHL | pdb_00001chl

NMR SEQUENTIAL ASSIGNMENTS AND SOLUTION STRUCTURE OF CHLOROTOXIN, A SMALL SCORPION TOXIN THAT BLOCKS CHLORIDE CHANNELS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1chla_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Short-chain scorpion toxins	Chlorootoxin	Egyptian scorpion (Leiurus quinquestriatus ) [TaxId: 6883 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Short-chain scorpion toxins	8025831	4003142	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Scorpion toxin-like	8038210	3000309	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Toxin_5	e1chlA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Toxin_5	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05294	Scorpion short toxin (Toxin_5)	Scorpion short toxin	This family contains various secreted scorpion short toxins and seems to be unrelated to Pfam:PF00451.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CHLOROTOXIN	monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity channel regulator activity ion channel regulator activity monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity transporter regulator activity transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity channel regulator activity ion channel regulator activity monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity transporter regulator activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel regulator activity chloride channel activity enzyme regulator activity peptidase activity molecular function inhibitor activity peptidase regulator activity catalytic activity, acting on a protein hydrolase activity enzyme inhibitor activity peptidase inhibitor activity catalytic activity toxin activity	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036574	Knottin, scorpion toxin-like superfamily	Homologous Superfamily
A	IPR007958	Scorpion short chain toxin, chloride channel inhibitor	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.