1D1M | pdb_00001d1m

CRYSTAL STRUCTURE OF CRO K56-[DGEVK]-F58W MUTANT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d1d1mb_	All alpha proteins	lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	Phage repressors	cro lambda repressor	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
B [auth A]	d1d1ma_	All alpha proteins	lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	Phage repressors	cro lambda repressor	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	lambda C1 repressor DNA-binding domain-like	8003968	3000119	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	lambda C1 repressor DNA-binding domain-like	8003968	3000119	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Cro	e1d1mB1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: Cro	ECOD (1.6)
B [auth A]	Cro	e1d1mA1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: Cro	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.30.240.10	Alpha Beta	2-Layer Sandwich	CRO Repressor	CRO Repressor	CATH (4.3.0)
B [auth A]	3.30.240.10	Alpha Beta	2-Layer Sandwich	CRO Repressor	CRO Repressor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF09048	Cro (Cro)	Cro	Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic ...	Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic growth. These proteins have a secondary structure consisting of three alpha-helices and three beta-sheets, and dimerise through interactions between the two antiparallel beta-strands [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	LAMBDA CRO REPRESSOR	DNA binding binding nucleic acid binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding core promoter sequence-specific DNA binding transcription regulatory region nucleic acid binding identical protein binding protein binding protein homodimerization activity protein dimerization activity	latent virus replication viral latency viral process release from viral latency latency-replication decision regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process latent virus replication viral latency viral process release from viral latency latency-replication decision regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of transcription by competitive promoter binding negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process response to light stimulus response to stimulus response to radiation response to abiotic stimulus response to UV viral gene expression regulation of viral process negative regulation of viral process regulation of viral transcription negative regulation of viral transcription viral transcription	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR000655	Regulatory protein cro-like	Family
A [auth B], B [auth A]	IPR038202	Regulatory protein cro superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.