1GH7 | pdb_00001gh7

CRYSTAL STRUCTURE OF THE COMPLETE EXTRACELLULAR DOMAIN OF THE BETA-COMMON RECEPTOR OF IL-3, IL-5, AND GM-CSF

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gh7a1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1gh7b1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibronectin type III	8055523	3002063	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Fibronectin type III	8055525	3002063	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Fibronectin type III	8055521	3002063	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Fibronectin type III	8055137	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055521	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055137	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055525	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055523	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL6Ra-bind	e1gh7A3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
A	IL4Ra_N_like	e1gh7A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL4Ra_N_like	ECOD (1.6)
A	fn3_6	e1gh7A4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)
B	IL6Ra-bind	e1gh7B3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
B	IL4Ra_N_like	e1gh7B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL4Ra_N_like	ECOD (1.6)
B	fn3_6	e1gh7B4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21460	GM-CSF/IL-3/IL-5 receptor common beta subunit, N-terminal (IL3Rb_N)	GM-CSF/IL-3/IL-5 receptor common beta subunit, N-terminal	GM-CSF/IL-3/IL-5 receptor common beta subunit (IL3RB) is a cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. It participates in ...	GM-CSF/IL-3/IL-5 receptor common beta subunit (IL3RB) is a cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. It participates in the signaling pathways of interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 which have overlapping activities on haematopoietic cells [1-4] and have been implicated in the pathogenesis of allergic diseases of the lung. IL3RB consists of four extracellular domains with an Ig-like fold. This entry represents the first domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CYTOKINE RECEPTOR COMMON BETA CHAIN	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity coreceptor activity	cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication cellular process signal transduction cell surface receptor signaling pathway via JAK-STAT response to cytokine cytokine-mediated signaling pathway cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell communication cellular process signal transduction cell surface receptor signaling pathway via JAK-STAT response to cytokine cytokine-mediated signaling pathway response to peptide response to chemical cellular response to cytokine stimulus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process cellular response to interleukin-3 response to interleukin-3 interleukin-5-mediated signaling pathway multicellular organismal process respiratory gaseous exchange by respiratory system granulocyte-macrophage colony-stimulating factor signaling pathway interleukin-3-mediated signaling pathway regulation of leukocyte proliferation cell population proliferation positive regulation of cell population proliferation positive regulation of biological process leukocyte proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation positive regulation of cellular process biological process involved in interspecies interaction between organisms response to lipid response to other organism response to oxygen-containing compound response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex granulocyte macrophage colony-stimulating factor receptor complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003961	Fibronectin type III	Domain
A, B	IPR011365	Cytokine IL-3/IL-5/GM-CSF receptor common beta chain	Family
A, B	IPR003531	Short hematopoietin receptor, family 1, conserved site	Conserved Site
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
A, B	IPR048668	Cytokine receptor common subunit beta, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P32927	surfactant metabolism dysfunction, pulmonary, 5 pulmonary alveolar proteinosis osteosarcoma periodontitis Psychotic Disorders sinusitis ulcerative colitis allergic rhinitis Crohn disease glioblastoma invasive ductal breast carcinoma lung carcinoma malignant colon neoplasm neonatal acute respiratory distress due to SP-B deficiency ovarian cancer surfactant metabolism dysfunction, pulmonary, 5 pulmonary alveolar proteinosis osteosarcoma periodontitis Psychotic Disorders sinusitis ulcerative colitis allergic rhinitis Crohn disease glioblastoma invasive ductal breast carcinoma lung carcinoma malignant colon neoplasm neonatal acute respiratory distress due to SP-B deficiency ovarian cancer pilocytic astrocytoma Sjogren syndrome cutaneous lupus erythematosus hereditary pulmonary alveolar proteinosis lung adenocarcinoma lymphoplasmacytic lymphoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis schizophrenia dermatomyositis interstitial cystitis lung cancer major depressive disorder malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.