Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Cd1guzc1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Cd1guzc2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Dd1guzd1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Dd1guzd2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Ad1guza1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Ad1guza2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Bd1guzb1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)
Bd1guzb2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain Malate dehydrogenase (Prosthecochloris vibrioformis ) [TaxId: 1098 ], (Chlorobaculum tepidum ) [TaxId: 1097 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
CLdh_1_C_6e1guzC3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_6ECOD (1.6)
CLdh_1_Ne1guzC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
DLdh_1_C_6e1guzD3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_6ECOD (1.6)
DLdh_1_Ne1guzD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
ALdh_1_C_6e1guzA1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_6ECOD (1.6)
ALdh_1_Ne1guzA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
BLdh_1_C_6e1guzB3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_6ECOD (1.6)
BLdh_1_Ne1guzB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF02866lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C)lactate/malate dehydrogenase, alpha/beta C-terminal domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Domain
A, B, C, D
PF00056lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N)lactate/malate dehydrogenase, NAD binding domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.
Domain