1H89 | pdb_00001h89

CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1h89a_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C/ebp beta	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1h89b_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C/ebp beta	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1h89c1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Myb/SANT domain	c-Myb, DNA-binding domain	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Leucine zipper-like	8044461	3001609	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leucine zipper-like	8044461	3001609	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Homeodomain-like	8057580	3000001	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Homeodomain-like	8057581	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Myb_DNA-binding_1	e1h89C3	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Myb_DNA-binding_1	ECOD (1.6)
C	Myb_DNA-binding_2	e1h89C2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Myb_DNA-binding_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07716	Basic region leucine zipper (bZIP_2)	Basic region leucine zipper	-	Coiled-coil
C	PF00249	Myb-like DNA-binding domain (Myb_DNA-binding)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CAAT/ENHANCER BINDING PROTEIN BETA	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding histone deacetylase binding protein binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding kinase binding ubiquitin-like protein ligase binding identical protein binding protein homodimerization activity protein dimerization activity chromatin binding chromatin DNA binding histone acetyltransferase binding	developmental process mammary gland epithelial cell differentiation epithelium development cellular developmental process mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development cell differentiation anatomical structure development cellular process regulation of defense response developmental process mammary gland epithelial cell differentiation epithelium development cellular developmental process mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development cell differentiation anatomical structure development cellular process regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response myeloid cell differentiation hemopoiesis myeloid cell development cell development negative regulation of lymphocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of leukocyte differentiation regulation of developmental process mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development regulation of multicellular organismal development regulation of dendritic cell differentiation regulation of hemopoiesis dendritic cell differentiation leukocyte differentiation biological process involved in interspecies interaction between organisms response to other organism response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus gonad development reproductive system development reproductive process female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development system development RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process acute-phase response acute inflammatory response cellular response to acid chemical cellular response to stimulus cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid fat cell differentiation brown fat cell differentiation regulation of biomineral tissue development positive regulation of developmental process positive regulation of biomineral tissue development biomineral tissue development interleukin-6 production regulation of interleukin-6 production regulation of cytokine production cytokine production signaling integrated stress response signaling intracellular signal transduction cell communication cellular response to stress intracellular signaling cassette signal transduction negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of fat cell differentiation positive regulation of cell differentiation regulation of fat cell differentiation positive regulation of cellular process regulation of localization sodium-dependent phosphate transport regulation of transport transport regulation of phosphate transport regulation of sodium-dependent phosphate transport establishment of localization localization positive regulation of transport positive regulation of sodium-dependent phosphate transport phosphate ion transport inorganic anion transport positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process response to endoplasmic reticulum stress immune response chronic inflammatory response granuloma formation immune effector process animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration nervous system development generation of neurons neurogenesis neuron differentiation regulation of odontoblast differentiation regulation of epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development epithelial cell proliferation mammary gland epithelial cell proliferation neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process epithelial cell proliferation involved in liver morphogenesis anatomical structure morphogenesis gland morphogenesis hepatocyte proliferation animal organ morphogenesis liver morphogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process myeloid leukocyte differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation ossification intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress apoptotic signaling pathway intrinsic apoptotic signaling pathway CD4-positive, alpha-beta T cell activation T-helper 1 cell activation alpha-beta T cell activation regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production positive regulation of gene expression positive regulation of cytokine production response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin	cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix RNA polymerase II transcription regulator complex protein-containing complex nuclear protein-containing complex transcription regulator complex CHOP-C/EBP complex nucleoplasm C/EBP complex chromosomal region chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome
C	MYB PROTO-ONCOGENE PROTEIN	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity WD40-repeat domain binding DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity WD40-repeat domain binding protein binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development cellular process leukocyte differentiation immune system development animal organ development gland development hematopoietic or lymphoid organ development multicellular organism development thymus development system development multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells myeloid cell differentiation myeloid cell development regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process digestive system development tube development embryo development digestive tract development embryonic organ development embryonic digestive tract development embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development spleen development RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-templated transcription response to peptide response to interleukin-6 response to stimulus cellular response to interleukin-6 response to chemical response to cytokine cellular response to cytokine stimulus mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process localization transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport stem cell division cell division positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cytoplasm cytosol membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
D	DNA(5'-(GPAPTPGPTPGPGPCPGPCPAP APTPCPCPTPTPAPAPCPGPGPAPCPTPG)-3')	-	-	-
E	DNA(5'-(CPCPAPGPTPCPCPGPTPTPAP APGPGPAPTPTPGPCPGPCPCPAPCPAPT)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031106	CCAAT/enhancer-binding protein C/EBP	Family
A, B	IPR004827	Basic-leucine zipper domain	Domain
A, B	IPR016468	CCAAT/enhancer-binding protein, chordates	Family
A, B	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
C	IPR015395	C-myb, C-terminal	Domain
C	IPR012642	Transcription regulator Wos2-domain	Domain
C	IPR017930	Myb domain	Domain
C	IPR050560	Transcription factors Myb-like	Family
C	IPR009057	Homedomain-like superfamily	Homologous Superfamily
C	IPR001005	SANT/Myb domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P17676	pulmonary fibrosis female infertility brain ischemia large cell medulloblastoma lung carcinoma medulloblastoma pituitary cancer astrocytic tumor ulcerative colitis Brain Injuries, Focal glioblastoma idiopathic interstitial pneumonia malignant pancreatic neoplasm ovarian cancer plasma cell myeloma pulmonary fibrosis female infertility brain ischemia large cell medulloblastoma lung carcinoma medulloblastoma pituitary cancer astrocytic tumor ulcerative colitis Brain Injuries, Focal glioblastoma idiopathic interstitial pneumonia malignant pancreatic neoplasm ovarian cancer plasma cell myeloma B-cell chronic lymphocytic leukemia brain injury breast cancer lung cancer MALT lymphoma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor cancer fatty liver disease gastric carcinoma hepatocellular carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.