1HTH | pdb_00001hth

The solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1htha_	Peptides	Parathyroid hormone fragments (residues between 1 and 39)	Parathyroid hormone fragments (residues between 1 and 39)	Parathyroid hormone fragments (residues between 1 and 39)	Parathyroid hormone fragments (residues between 1 and 39)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01279	Parathyroid hormone family (Parathyroid)	Parathyroid hormone family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CYCLIC PARATHYROID HORMONE	parathyroid hormone receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding type 1 parathyroid hormone receptor binding molecular transducer activity molecular function activator activity signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity peptide hormone receptor binding parathyroid hormone receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding type 1 parathyroid hormone receptor binding molecular transducer activity molecular function activator activity signaling receptor activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity peptide hormone receptor binding hormone receptor binding hormone activity	response to stimulus response to chemical response to xenobiotic stimulus response to parathyroid hormone response to hormone response to endogenous stimulus magnesium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis developmental process multicellular organismal process response to stimulus response to chemical response to xenobiotic stimulus response to parathyroid hormone response to hormone response to endogenous stimulus magnesium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development multicellular organismal-level homeostasis homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells biosynthetic process metabolic process cellular process macromolecule metabolic process macromolecule biosynthetic process multicellular organism development skeletal system development system development regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II negative regulation of apoptotic process in bone marrow cell negative regulation of programmed cell death apoptotic process in bone marrow cell regulation of apoptotic process in bone marrow cell regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of generation of precursor metabolites and energy regulation of primary metabolic process positive regulation of glycogen metabolic process regulation of small molecule metabolic process small molecule metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process positive regulation of carbohydrate metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process glucose metabolic process phosphate ion homeostasis signaling cell-cell signaling cell communication intracellular calcium ion homeostasis calcium ion homeostasis cellular homeostasis intracellular monoatomic cation homeostasis intracellular chemical homeostasis intracellular monoatomic ion homeostasis regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process positive regulation of biomineral tissue development regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification response to alcohol response to oxygen-containing compound response to ethanol cellular response to stimulus adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction response to metal ion response to lead ion cell population proliferation positive regulation of cell population proliferation positive regulation of cell proliferation in bone marrow cell proliferation in bone marrow regulation of cell proliferation in bone marrow regulation of cell population proliferation response to nutrient levels response to vitamin D response to lipid response to nutrient response to vitamin hormone-mediated signaling pathway apoptotic signaling pathway cellular response to endogenous stimulus cellular response to chemical stimulus hormone-mediated apoptotic signaling pathway cellular response to hormone stimulus nucleoside phosphate metabolic process ribose phosphate metabolic process cAMP metabolic process cyclic purine nucleotide metabolic process carbohydrate derivative metabolic process nucleotide metabolic process cyclic nucleotide metabolic process purine-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process purine ribonucleotide metabolic process phosphorus metabolic process regulation of cartilage development regulation of chondrocyte differentiation connective tissue development cellular developmental process negative regulation of cartilage development negative regulation of chondrocyte differentiation regulation of cell differentiation cell differentiation negative regulation of cell differentiation negative regulation of developmental process chondrocyte differentiation negative regulation of multicellular organismal process cartilage development negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process regulation of localization hexose transmembrane transport D-glucose import transport carbohydrate transport positive regulation of D-glucose transmembrane transport localization positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transport establishment of localization transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport positive regulation of cell communication regulation of signaling positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication positive regulation of signaling response to cadmium ion small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette regulation of leukocyte proliferation osteoclast proliferation regulation of osteoclast proliferation positive regulation of osteoclast proliferation leukocyte proliferation positive regulation of leukocyte proliferation bone maturation regulation of bone mineralization involved in bone maturation negative regulation of biomineral tissue development negative regulation of bone mineralization ossification involved in bone maturation bone development bone mineralization involved in bone maturation developmental maturation negative regulation of bone mineralization involved in bone maturation negative regulation of ossification anatomical structure maturation animal organ maturation positive regulation of DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of inositol phosphate biosynthetic process alcohol metabolic process positive regulation of phosphate metabolic process inositol phosphate metabolic process regulation of phosphate metabolic process polyol biosynthetic process polyol metabolic process positive regulation of phosphorus metabolic process regulation of alcohol biosynthetic process small molecule biosynthetic process positive regulation of inositol phosphate biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process alcohol biosynthetic process regulation of phosphorus metabolic process positive regulation of alcohol biosynthetic process tissue remodeling bone remodeling bone resorption response to fibroblast growth factor response to growth factor	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001415	Parathyroid hormone/parathyroid hormone-related protein	Family
A	IPR003625	Parathyroid hormone	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P01270	rickets hypercalcemia disease hyperphosphatemia uremia Hypocalcemia hypertensive disorder anemia osteoporosis secondary hyperparathyroidism hyperostosis hypoparathyroidism, familial isolated 1 nevoid basal cell carcinoma syndrome familial hypoparathyroidism congestive heart failure postmenopausal osteoporosis rickets hypercalcemia disease hyperphosphatemia uremia Hypocalcemia hypertensive disorder anemia osteoporosis secondary hyperparathyroidism hyperostosis hypoparathyroidism, familial isolated 1 nevoid basal cell carcinoma syndrome familial hypoparathyroidism congestive heart failure postmenopausal osteoporosis adenoma kidney failure bone fracture multiple endocrine neoplasia calcinosis nephrolithiasis diabetes mellitus osteomalacia primary hyperparathyroidism hypoparathyroidism cancer digestive system disease pseudohypoparathyroidism hyperparathyroidism hyperthyroidism hypophosphatemia bone resorption disease nephrocalcinosis osteitis fibrosa heart failure renal osteodystrophy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.