1HTJ | pdb_00001htj

STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth F]	d1htjf_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Pdz-RhoGEF RGS-like domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth F]	SCOP2 Family	Regulator of G-protein signaling, RGS	8020924	4001125	SCOP2 (2022-06-29)
A [auth F]	SCOP2 Superfamily	Regulator of G-protein signaling, RGS	8033304	3000835	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth F]	RGS-like	e1htjF1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: RGS-like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth F]	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth F]	PF09128	Regulator of G protein signalling-like domain (RGS-like)	Regulator of G protein signalling-like domain	Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices ...	Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS (Pfam:PF00615) fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. Members of the family bind to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F]	KIAA0380	pyrophosphatase activity enzyme regulator activity GTPase activity molecular function activator activity nucleoside-triphosphatase regulator activity hydrolase activity GTPase regulator activity enzyme activator activity ribonucleoside triphosphate phosphatase activity GTPase activator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular function regulator activity hydrolase activity, acting on acid anhydrides catalytic activity pyrophosphatase activity enzyme regulator activity GTPase activity molecular function activator activity nucleoside-triphosphatase regulator activity hydrolase activity GTPase regulator activity enzyme activator activity ribonucleoside triphosphate phosphatase activity GTPase activator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular function regulator activity hydrolase activity, acting on acid anhydrides catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding small molecule binding protein binding signaling receptor binding G protein-coupled receptor binding	multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of growth regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation growth regulation of cell growth cell growth cellular component organization multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of growth regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation growth regulation of cell growth cell growth cellular component organization cellular process cellular component organization or biogenesis establishment of cell polarity establishment or maintenance of cell polarity organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process G protein-coupled receptor signaling pathway Rho protein signal transduction	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth F]	IPR016137	RGS domain	Domain
A [auth F]	IPR001849	Pleckstrin homology domain	Domain
A [auth F]	IPR036305	RGS domain superfamily	Homologous Superfamily
A [auth F]	IPR000219	Dbl homology domain	Domain
A [auth F]	IPR011993	PH-like domain superfamily	Homologous Superfamily
A [auth F]	IPR037803	Rho guanine nucleotide exchange factor 11, PH domain	Domain
A [auth F]	IPR041020	ARHGEF1-like, PH domain	Domain
A [auth F]	IPR037889	Rho guanine nucleotide exchange factor 11, RGS domain	Domain
A [auth F]	IPR015212	Regulator of G protein signalling-like domain	Domain
A [auth F]	IPR044926	RGS, subdomain 2	Homologous Superfamily
A [auth F]	IPR036034	PDZ superfamily	Homologous Superfamily
A [auth F]	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A [auth F]	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth F]	Pharos: O15085	schizophrenia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.