1IW8 | pdb_00001iw8

Crystal Structure of a mutant of acid phosphatase from Escherichia blattae (G74D/I153T)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1iw8a_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)
B	d1iw8b_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)
C	d1iw8c_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)
D	d1iw8d_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)
E	d1iw8e_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)
F	d1iw8f_	All alpha proteins	Acid phosphatase/Vanadium-dependent haloperoxidase	Acid phosphatase/Vanadium-dependent haloperoxidase	Type 2 phosphatidic acid phosphatase, PAP2	Bacterial acid phosphatase	(Shimwellia blattae ) [TaxId: 563 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Acid phosphatase/Vanadium-dependent haloperoxidase	8032791	3001110	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAP2	e1iw8A1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)
B	PAP2	e1iw8B1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)
C	PAP2	e1iw8C1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)
D	PAP2	e1iw8D1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)
E	PAP2	e1iw8E1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)
F	PAP2	e1iw8F1	A: alpha bundles	X: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	H: Acid phosphatase/Vanadium-dependent haloperoxidase (From Topology)	T: Acid phosphatase/Vanadium-dependent haloperoxidase	F: PAP2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)
B	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)
C	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)
D	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)
E	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)
F	1.20.144.10	Mainly Alpha	Up-down Bundle	Vanadium-containing Chloroperoxidase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01569	PAP2 superfamily (PAP2)	PAP2 superfamily	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	acid phosphatase	phosphoric ester hydrolase activity acid phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity	-	cellular anatomical structure outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036938	Phosphatidic acid phosphatase type 2/haloperoxidase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR018296	Acid phosphatase, class A, bacterial, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR054904	Non-specific acid phosphatase	Family
A, B, C, D, E A, B, C, D, E, F	IPR001011	Acid phosphatase, class A, bacterial	Family
A, B, C, D, E A, B, C, D, E, F	IPR000326	Phosphatidic acid phosphatase type 2/haloperoxidase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.