1KVD | pdb_00001kvd

KILLER TOXIN FROM HALOTOLERANT YEAST

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kvd.1	Alpha and beta proteins (a+b)	Yeast killer toxins	Yeast killer toxins	SMK toxin	SMK toxin	(Millerozyma farinosa ) [TaxId: 4920 ],	SCOPe (2.08)
C	d1kvd.2	Alpha and beta proteins (a+b)	Yeast killer toxins	Yeast killer toxins	SMK toxin	SMK toxin	(Millerozyma farinosa ) [TaxId: 4920 ],	SCOPe (2.08)
B	d1kvd.1	Alpha and beta proteins (a+b)	Yeast killer toxins	Yeast killer toxins	SMK toxin	SMK toxin	(Millerozyma farinosa ) [TaxId: 4920 ],	SCOPe (2.08)
D	d1kvd.2	Alpha and beta proteins (a+b)	Yeast killer toxins	Yeast killer toxins	SMK toxin	SMK toxin	(Millerozyma farinosa ) [TaxId: 4920 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.420.10	Few Secondary Structures	Irregular	Smk Toxin, alpha chain	Smk Toxin, alpha chain	CATH (4.3.0)
C	4.10.420.10	Few Secondary Structures	Irregular	Smk Toxin, alpha chain	Smk Toxin, alpha chain	CATH (4.3.0)
B	3.30.44.10	Alpha Beta	2-Layer Sandwich	Smk Toxin, Beta chain	Smk Toxin, beta chain	CATH (4.3.0)
D	3.30.44.10	Alpha Beta	2-Layer Sandwich	Smk Toxin, Beta chain	Smk Toxin, beta chain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF21415	SMK1 alpha subunit (SMK1_alpha_su)	SMK1 alpha subunit	-	Family
B, D	PF21414	Salt-mediated killer protoxin 1, beta subunit (SMK_beta_su)	Salt-mediated killer protoxin 1, beta subunit	The killer toxin SMK (salt-mediated killer) from the halotolerant yeast Pichia farinosa acts to kill sensitive strains of yeast. SMK exhibits maximum activity under conditions of acidic pH and high salt concentration. It is composed of two distinct s ...	The killer toxin SMK (salt-mediated killer) from the halotolerant yeast Pichia farinosa acts to kill sensitive strains of yeast. SMK exhibits maximum activity under conditions of acidic pH and high salt concentration. It is composed of two distinct subunits, alpha and beta, which tightly interact with each other under acidic conditions, jointly folding into an ellipsoidal single domain structure belonging to the alpha/beta-sandwich family. SMK assumes a similar folding topology to the fungal killer toxin KP4, forming two left-handed split beta/alpha/beta motifs which is rarely found in other toxins; hence, these toxins may be evolutionarily or functionally related [1]. SMK appears to function by associating with the membranes of sensitive cells [2]. This entry represents SMK beta subunit.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	SMK TOXIN	molecular sequestering activity toxin sequestering activity toxin activity	biological process involved in interspecies interaction between organisms cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	cellular anatomical structure extracellular region protein-containing complex
B, D	SMK TOXIN	molecular sequestering activity toxin sequestering activity toxin activity	biological process involved in interspecies interaction between organisms cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	cellular anatomical structure extracellular region protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR048754	SMK1 alpha subunit	Domain
A, C	IPR011329	Killer toxin Kp4/SMK	Homologous Superfamily
A, C	IPR011327	Killer toxin, SMK, beta subunit	Domain
A, C	IPR038431	Killer toxin SMK, beta subunit superfamily	Homologous Superfamily
A, C	IPR011328	Salt-mediated killer toxin, alpha subunit	Homologous Superfamily
B, D	IPR048754	SMK1 alpha subunit	Domain
B, D	IPR011329	Killer toxin Kp4/SMK	Homologous Superfamily
B, D	IPR011327	Killer toxin, SMK, beta subunit	Domain
B, D	IPR038431	Killer toxin SMK, beta subunit superfamily	Homologous Superfamily
B, D	IPR011328	Salt-mediated killer toxin, alpha subunit	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.