1NN4

Structural Genomics, RpiB/AlsB

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1nn4a1	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1nn4a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1nn4b1	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1nn4b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1nn4d1	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1nn4d2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1nn4c1	Alpha and beta proteins (a/b)	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Ribose/Galactose isomerase RpiB/AlsB	Alternate ribose 5-phosphate isomerase B, RpiB	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1nn4c2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ribose/Galactose isomerase RpiB/AlsB	8021080	4000476	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8033460	3000383	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8033460	3000383	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8033460	3000383	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribose/Galactose isomerase RpiB/AlsB	8033460	3000383	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LacAB_rpiB,RNAse_Pc_like	e1nn4A1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB,RNAse_Pc_like	ECOD (1.6)
B	LacAB_rpiB,RNAse_Pc_like	e1nn4B1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB,RNAse_Pc_like	ECOD (1.6)
D	LacAB_rpiB,RNAse_Pc_like	e1nn4D1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB,RNAse_Pc_like	ECOD (1.6)
C	LacAB_rpiB,RNAse_Pc_like	e1nn4C1	A: a/b three-layered sandwiches	X: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	H: Ribose/Galactose isomerase RpiB/AlsB (From Topology)	T: Ribose/Galactose isomerase RpiB/AlsB	F: LacAB_rpiB,RNAse_Pc_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
B	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
D	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)
C	3.40.1400.10	Alpha Beta	3-Layer(aba) Sandwich	Ribose 5-phosphate Isomerase B	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02502	Ribose/Galactose Isomerase (LacAB_rpiB)	Ribose/Galactose Isomerase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ribose 5-phosphate isomerase B	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity ribose-5-phosphate isomerase activity catalytic activity D-allose 6-phosphate isomerase activity	monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process D-allose metabolic process small molecule metabolic process metabolic process cellular process D-allose catabolic process monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process D-allose metabolic process small molecule metabolic process metabolic process cellular process D-allose catabolic process monosaccharide catabolic process small molecule catabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process generation of precursor metabolites and energy nucleotide metabolic process aldehyde metabolic process purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process pentose-phosphate shunt, non-oxidative branch	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036569	Sugar-phosphate isomerase, RpiB/LacA/LacB superfamily	Homologous Superfamily
A, B, C, D	IPR003500	Sugar-phosphate isomerase, RpiB/LacA/LacB family	Family
A, B, C, D	IPR004785	Ribose 5-phosphate isomerase B	Family
A, B, C, D	IPR051812	Sugar Phosphate Isomerase LacAB/RpiB	Family

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A, D	ribose-5-phosphate isomerase M-CSA #680	Ribose-5-phosphate isomerase is able to catalyse the interconversion of Ribose-5-phosphate and Ribulose-5-phosphate, an isomerisation reaction involving the open chain forms of the two sugars, important in the pentose phosphate pathway. In Escherichia coli there are two forms of the enzyme, which although they catalyse the same reaction, have entirely different mechanisms and catalytic residues. The less common Escherichia coli RpiB is described here.	Defined by 5 residues: ASP:A-22 [auth A-9]CYS:A-79 [auth A-66]THR:A-81 [auth A-68]HIS:D-112 [auth D-99]HIS:D-147 [auth D-134] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.3.1.6 (PDB Primary Data) Search M-CSA Motif + EC 5.3.1.6

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.