Annotations: 1OA8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oa8a_	All beta proteins	AXH domain	AXH domain	AXH domain	Ataxin-1	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1oa8b_	All beta proteins	AXH domain	AXH domain	AXH domain	Ataxin-1	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1oa8c_	All beta proteins	AXH domain	AXH domain	AXH domain	Ataxin-1	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1oa8d_	All beta proteins	AXH domain	AXH domain	AXH domain	Ataxin-1	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	AXH domain	8024987	4000942	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	AXH domain	8037366	3000204	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	AXH domain	8037366	3000204	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	AXH domain	8037366	3000204	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	AXH domain	8037366	3000204	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AXH	e1oa8A1	A: beta complex topology	X: Hedgehog/intein (From Homology)	H: Hedgehog/intein	T: AXH	F: AXH	ECOD (1.6)
B	AXH	e1oa8B1	A: beta complex topology	X: Hedgehog/intein (From Homology)	H: Hedgehog/intein	T: AXH	F: AXH	ECOD (1.6)
C	AXH	e1oa8C1	A: beta complex topology	X: Hedgehog/intein (From Homology)	H: Hedgehog/intein	T: AXH	F: AXH	ECOD (1.6)
D	AXH	e1oa8D1	A: beta complex topology	X: Hedgehog/intein (From Homology)	H: Hedgehog/intein	T: AXH	F: AXH	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08517	Ataxin-1 and HBP1 module (AXH) (AXH)	Ataxin-1 and HBP1 module (AXH)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ATAXIN-1	chromatin binding binding RNA binding nucleic acid binding DNA binding poly(G) binding poly-purine tract binding single-stranded RNA binding poly-pyrimidine tract binding poly(U) RNA binding identical protein binding protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development behavior system process learning learning or memory nervous system process cognition memory RNA processing localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport nuclear export establishment of localization biological process involved in intraspecies interaction between organisms social behavior transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix intracellular membraneless organelle nucleolus membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen nuclear matrix intracellular membraneless organelle nucleolus membraneless organelle cytoplasm cytosol nucleoplasm inclusion body nuclear inclusion body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003652	Ataxin, AXH domain	Domain
A, B, C, D	IPR043404	ATAXIN1-like	Family
A, B, C, D	IPR020997	Ataxin-1, N-terminal	Domain
A, B, C, D	IPR036096	Ataxin, AXH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P54253	spinocerebellar ataxia type 1 neurodegenerative disease autosomal dominant cerebellar ataxia retinal disease atrial fibrillation medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis spinocerebellar ataxia type 4 amyotrophic lateral sclerosis spinocerebellar ataxia type 7 atypical teratoid rhabdoid tumor tuberculosis cerebellar ataxia spinocerebellar ataxia type 1 neurodegenerative disease autosomal dominant cerebellar ataxia retinal disease atrial fibrillation medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis spinocerebellar ataxia type 4 amyotrophic lateral sclerosis spinocerebellar ataxia type 7 atypical teratoid rhabdoid tumor tuberculosis cerebellar ataxia Degenerative Diseases, Central Nervous System glioblastoma large cell medulloblastoma malignant glioma ovarian cancer primitive neuroectodermal tumor spinocerebellar ataxia type 5 astrocytic tumor subependymal giant cell astrocytoma hepatocellular carcinoma lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma spinocerebellar ataxia type 2 spinocerebellar ataxia type 6 systemic lupus erythematosus B-cell chronic lymphocytic leukemia cystic fibrosis dermatomyositis hereditary ataxia malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.