1PV9 | pdb_00001pv9

Prolidase from Pyrococcus furiosus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pv9a1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Creatinase/prolidase N-terminal domain	Creatinase/prolidase N-terminal domain	Aminopeptidase P	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
A	d1pv9a2	Alpha and beta proteins (a+b)	Creatinase/aminopeptidase	Creatinase/aminopeptidase	Creatinase/aminopeptidase	Aminopeptidase P, C-terminal domain	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
B	d1pv9b1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Creatinase/prolidase N-terminal domain	Creatinase/prolidase N-terminal domain	Aminopeptidase P	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
B	d1pv9b2	Alpha and beta proteins (a+b)	Creatinase/aminopeptidase	Creatinase/aminopeptidase	Creatinase/aminopeptidase	Aminopeptidase P, C-terminal domain	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Creatinase/prolidase N-terminal domain	8026774	4000535	SCOP2 (2022-06-29)
A	SCOP2 Family	Creatinase/aminopeptidase-like	8026777	4000207	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Creatinase/prolidase N-terminal domain-like	8039153	3000538	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Creatinase/aminopeptidase catalytic domain-like	8039156	3000126	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Creatinase/aminopeptidase catalytic domain-like	8039156	3000126	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Creatinase/prolidase N-terminal domain-like	8039153	3000538	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M24	e1pv9A1	A: a+b duplicates or obligate multimers	X: Creatinase/aminopeptidase-like	H: Creatinase/aminopeptidase (From Topology)	T: Creatinase/aminopeptidase	F: Peptidase_M24	ECOD (1.6)
A	Creatinase_N	e1pv9A2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Creatinase/prolidase N-terminal domain (From Topology)	T: Creatinase/prolidase N-terminal domain	F: Creatinase_N	ECOD (1.6)
B	Peptidase_M24	e1pv9B1	A: a+b duplicates or obligate multimers	X: Creatinase/aminopeptidase-like	H: Creatinase/aminopeptidase (From Topology)	T: Creatinase/aminopeptidase	F: Peptidase_M24	ECOD (1.6)
B	Creatinase_N	e1pv9B2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Creatinase/prolidase N-terminal domain (From Topology)	T: Creatinase/prolidase N-terminal domain	F: Creatinase_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.350.10	Alpha Beta	3-Layer(aba) Sandwich	Creatine Amidinohydrolase	Chain A, domain 1	CATH (4.3.0)
A	3.90.230.10	Alpha Beta	Alpha-Beta Complex	Creatine Amidinohydrolase	Creatinase/methionine aminopeptidase superfamily	CATH (4.3.0)
B	3.40.350.10	Alpha Beta	3-Layer(aba) Sandwich	Creatine Amidinohydrolase	Chain A, domain 1	CATH (4.3.0)
B	3.90.230.10	Alpha Beta	Alpha-Beta Complex	Creatine Amidinohydrolase	Creatinase/methionine aminopeptidase superfamily	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00557	Metallopeptidase family M24 (Peptidase_M24)	Metallopeptidase family M24	This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3].	Domain
A, B	PF01321	Creatinase/Prolidase N-terminal domain (Creatinase_N)	Creatinase/Prolidase N-terminal domain	This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Xaa-Pro dipeptidase	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity proline dipeptidase activity exopeptidase activity dipeptidase activity cation binding ion binding binding metal ion binding small molecule binding	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001714	Peptidase M24, methionine aminopeptidase	Family
A, B	IPR001131	Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site	Conserved Site
A, B	IPR000587	Creatinase, N-terminal	Domain
A, B	IPR029149	Creatinase/Aminopeptidase P/Spt16, N-terminal	Homologous Superfamily
A, B	IPR050659	Peptidase M24B family	Family
A, B	IPR053500	Prolidase archaeal-type	Family
A, B	IPR036005	Creatinase/aminopeptidase-like	Homologous Superfamily
A, B	IPR000994	Peptidase M24	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.