Annotations: 1QZF


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1qzfa1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ad1qzfa2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Bd1qzfb1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Bd1qzfb2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Cd1qzfc1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Cd1qzfc2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Dd1qzfd1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Dd1qzfd2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ed1qzfe1 Alpha and beta proteins (a/b) Dihydrofolate reductase-like Dihydrofolate reductase-like Dihydrofolate reductases Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)
Ed1qzfe2 Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain (Cryptosporidium hominis ) [TaxId: 237895 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDihydrofolate reductase-like 8039373 3001255 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDihydrofolate reductase-like 8039373 3001255 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyDihydrofolate reductase-like 8039373 3001255 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyDihydrofolate reductase-like 8039373 3001255 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyDihydrofolate reductase-like 8039373 3001255 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte1qzfA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
ADHFR_1e1qzfA2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
BThymidylat_synte1qzfB1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BDHFR_1e1qzfB2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
CThymidylat_synte1qzfC1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
CDHFR_1e1qzfC2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
DThymidylat_synte1qzfD2 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DDHFR_1e1qzfD3 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
EThymidylat_synte1qzfE1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
EDHFR_1e1qzfE2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain
A, B, C, D, E
PF00186Dihydrofolate reductase (DHFR_1)Dihydrofolate reductase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
bifunctional dihydrofolate reductase-thymidylate synthase