1RSO | pdb_00001rso

Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rsoa_	All alpha proteins	L27 domain	L27 domain	L27 domain	Presynaptic protein sap97	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1rsoc_	All alpha proteins	L27 domain	L27 domain	L27 domain	Presynaptic protein sap97	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1rsob_	All alpha proteins	L27 domain	L27 domain	L27 domain	Peripheral plasma membrane protein cask	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1rsod_	All alpha proteins	L27 domain	L27 domain	L27 domain	Peripheral plasma membrane protein cask	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	L27 domain	8028516	4000688	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L27 domain	8040895	3001054	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	L27 domain	8040895	3001054	SCOP2B (2022-06-29)
B	SCOP2 Family	L27 domain	8028519	4000688	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	L27 domain	8040898	3001054	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	L27 domain	8040898	3001054	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	L27_1	e1rsoA1	A: alpha duplicates or obligate multimers	X: L27 domain (From Topology)	H: L27 domain (From Topology)	T: L27 domain	F: L27_1	ECOD (1.6)
C	L27_1	e1rsoC1	A: alpha duplicates or obligate multimers	X: L27 domain (From Topology)	H: L27 domain (From Topology)	T: L27 domain	F: L27_1	ECOD (1.6)
B	L27_1	e1rsoB1	A: alpha duplicates or obligate multimers	X: L27 domain (From Topology)	H: L27 domain (From Topology)	T: L27 domain	F: L27_1	ECOD (1.6)
D	L27_1	e1rsoD1	A: alpha duplicates or obligate multimers	X: L27 domain (From Topology)	H: L27 domain (From Topology)	T: L27 domain	F: L27_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
C	1.10.287.470	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)
B	1.10.287.650	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	L27 domain	CATH (4.3.0)
D	1.10.287.650	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	L27 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF09058	L27_1 (L27_1)	L27_1	The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form spe ...	The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices [1].	Domain
B, D	PF02828	L27 domain (L27)	L27 domain	The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Presynaptic protein SAP97	structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization monoatomic cation transmembrane transporter activity channel regulator activity ion channel regulator activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity potassium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity structural constituent of postsynapse structural molecule activity structural constituent of postsynaptic density structural constituent of synapse structural constituent of postsynaptic specialization monoatomic cation transmembrane transporter activity channel regulator activity ion channel regulator activity monoatomic ion channel activity potassium ion transmembrane transporter activity potassium channel activity potassium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity molecular function regulator activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transporter regulator activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding protein binding binding kinesin binding L27 domain binding protein domain specific binding PDZ domain binding kinase binding enzyme binding protein kinase binding molecular adaptor activity phosphatase binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding transmembrane transporter binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus response to nerve growth factor response to growth factor protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus response to nerve growth factor response to growth factor developmental process multicellular organismal process sensory organ development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development lens development in camera-type eye system development positive regulation of protein localization to plasma membrane regulation of localization regulation of cellular process regulation of protein localization positive regulation of biological process regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization positive regulation of protein localization regulation of protein localization to plasma membrane heart process system process regulation of actin filament-based process cardiac muscle cell action potential involved in contraction regulation of ventricular cardiac muscle cell action potential regulation of heart contraction regulation of system process cardiac muscle contraction striated muscle contraction circulatory system process regulation of cardiac muscle cell action potential actin filament-based process regulation of multicellular organismal process regulation of biological quality blood circulation cardiac muscle cell contraction regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction action potential actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction heart contraction cardiac muscle cell action potential regulation of membrane potential negative regulation of lymphocyte proliferation regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of immune system process regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade protein-containing complex localization tissue morphogenesis anatomical structure morphogenesis tissue development bicellular tight junction assembly tight junction organization apical junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization regulation of potassium ion transport transport regulation of transport regulation of monoatomic ion transport establishment of localization metal ion transport positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport nervous system development metabolic process primary metabolic process protein metabolic process macromolecule metabolic process amyloid precursor protein metabolic process trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport export across plasma membrane potassium ion export across plasma membrane monoatomic cation transmembrane transport export from cell inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of potassium ion export across plasma membrane regulation of monoatomic cation transmembrane transport RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process organelle organization actin cytoskeleton organization actin filament organization supramolecular fiber organization cytoskeleton organization receptor clustering smooth muscle contraction phasic smooth muscle contraction peristalsis endothelial cell proliferation epithelial cell proliferation membrane organization membrane raft organization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization protein-containing complex assembly protein localization to synapse protein localization to cell junction receptor localization to synapse positive regulation of cell population proliferation positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization positive regulation of cellular component organization regulation of cellular component size regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization regulation of actin filament polymerization regulation of actin filament organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization positive regulation of actin filament polymerization regulation of anatomical structure size establishment of organelle localization centrosome localization organelle localization establishment of localization in cell microtubule organizing center localization establishment of centrosome localization establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity protein localization to postsynaptic specialization membrane protein localization to postsynaptic membrane neurotransmitter receptor localization to postsynaptic specialization membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle protein localization to postsynapse positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process hard palate development secondary palate development roof of mouth development embryonic organ morphogenesis chordate embryonic development embryonic morphogenesis embryo development embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development cortical actin cytoskeleton organization cortical cytoskeleton organization regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction reproductive system development reproductive process reproductive structure development developmental process involved in reproduction regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis renal tubule development epithelial tube morphogenesis nephron development nephron epithelium development ureteric bud development epithelium development tube development mesonephros development morphogenesis of an epithelium kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium regulation of protein localization to synapse regulation of multicellular organismal development regulation of developmental process regulation of myelination regulation of nervous system development myelination axon ensheathment ensheathment of neurons microtubule cytoskeleton organization cytoplasmic microtubule organization cortical microtubule organization microtubule-based process negative regulation of p38MAPK cascade p38MAPK cascade regulation of p38MAPK cascade import into cell potassium ion import across plasma membrane import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane regulation of potassium ion import regulation of cell shape cell morphogenesis regulation of cell morphogenesis regulation of anatomical structure morphogenesis astral microtubule organization cell cycle spindle organization cell cycle process regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition immunological synapse formation cell-cell recognition cell recognition muscle tissue development smooth muscle tissue development multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process anatomical structure homeostasis tissue homeostasis	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region sarcolemma T-tubule cell-cell junction anchoring junction intracellular anatomical structure cytoplasm cytosol neuromuscular junction apical part of cell apical plasma membrane axon cell projection main axon neuron projection node of Ranvier plasma membrane bounded cell projection basal part of cell basal plasma membrane cell projection membrane membrane microdomain membrane raft membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane immunological synapse lateral plasma membrane lateral loop myelin sheath myelin sheath abaxonal region basement membrane extracellular matrix external encapsulating structure presynapse presynaptic membrane basolateral plasma membrane somatodendritic compartment dendrite dendritic tree glutamatergic synapse Golgi apparatus actin-based cell projection microvillus perinuclear region of cytoplasm cell body neuronal cell body postsynaptic density, intracellular component intracellular membraneless organelle postsynaptic specialization, intracellular component membraneless organelle intracellular vesicle transport vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle polymeric cytoskeletal fiber cytoskeleton supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton paranode region of axon adherens junction protein-containing complex plasma membrane protein complex membrane protein complex MPP7-DLG1-LIN7 complex apical junction complex bicellular tight junction tight junction cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane nucleus
B, D	Peripheral plasma membrane protein CASK	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding protein binding calmodulin binding histone H3T6 kinase activity histone H3T3 kinase activity signaling receptor binding neurexin family protein binding histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity PDZ domain binding protein domain specific binding histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity histone H3T11 kinase activity kinase binding protein kinase C binding enzyme binding protein kinase binding histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane regulation of biological process cellular response to growth factor stimulus response to stimulus negative regulation of response to stimulus protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane regulation of biological process cellular response to growth factor stimulus response to stimulus negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation negative regulation of biological process negative regulation of cellular response to growth factor stimulus cellular response to endogenous stimulus regulation of response to stimulus response to growth factor wound healing regulation of response to external stimulus negative regulation of wound healing response to external stimulus negative regulation of response to wounding regulation of response to wounding response to stress regulation of response to stress negative regulation of response to external stimulus regulation of wound healing response to wounding regulation of localization regulation of cellular process transport modulation of chemical synaptic transmission signaling cell communication synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport establishment of localization regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication developmental process multicellular organismal process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development regulation of calcium ion import regulation of calcium ion transport positive regulation of calcium ion transport positive regulation of calcium ion import regulation of monoatomic ion transport positive regulation of biological process calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport negative regulation of cell population proliferation cell population proliferation regulation of keratinocyte proliferation negative regulation of keratinocyte proliferation regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation keratinocyte proliferation positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport vesicle-mediated transport in synapse regulation of regulated secretory pathway regulation of synaptic vesicle exocytosis regulation of vesicle-mediated transport exocytosis regulation of exocytosis positive regulation of dendritic spine morphogenesis positive regulation of nervous system development cell projection organization positive regulation of dendritic spine development regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell morphogenesis regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation regulation of dendrite morphogenesis regulation of synapse structure or activity positive regulation of cell projection organization synapse organization regulation of biological quality dendritic spine morphogenesis dendritic spine development postsynapse organization dendritic spine organization regulation of cell projection organization positive regulation of cell development regulation of postsynapse organization positive regulation of cell morphogenesis generation of neurons regulation of dendrite development positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development regulation of dendritic spine development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis dendrite development positive regulation of neuron projection development positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization dendrite morphogenesis positive regulation of dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis regulation of synapse organization cell junction organization neuron development regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization regulation of cell-substrate adhesion regulation of cell adhesion cell-substrate adhesion negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell adhesion cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion positive regulation of cell communication establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion positive regulation of hormone secretion positive regulation of secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion positive regulation of signaling	cellular anatomical structure membrane cell-cell junction anchoring junction cell junction basement membrane cell periphery extracellular matrix external encapsulating structure intracellular anatomical structure cytoplasm cytosol presynapse synapse cellular anatomical structure membrane cell-cell junction anchoring junction cell junction basement membrane cell periphery extracellular matrix external encapsulating structure intracellular anatomical structure cytoplasm cytosol presynapse synapse plasma membrane presynaptic membrane plasma membrane region synaptic membrane basal part of cell basal plasma membrane basolateral plasma membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection glutamatergic synapse perinuclear region of cytoplasm cell body neuronal cell body postsynaptic density, intracellular component postsynaptic specialization intracellular membraneless organelle postsynaptic specialization, intracellular component intracellular organelle postsynaptic density postsynapse neuron to neuron synapse organelle membraneless organelle asymmetric synapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix podocyte foot nucleolus vesicle protein-containing complex cilium ciliary membrane bounding membrane of organelle organelle membrane cell projection membrane endomembrane system organelle envelope nuclear envelope nuclear periphery nuclear lamina Schaffer collateral - CA1 synapse apical dendrite

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR015143	L27-1	Domain
A, C	IPR016313	Disks large 1-like	Family
A, C	IPR019590	Disks large homologue 1, N-terminal PEST domain	Domain
A, C	IPR008144	Guanylate kinase-like domain	Domain
A, C	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
A, C	IPR001478	PDZ domain	Domain
A, C	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, C	IPR020590	Guanylate kinase, conserved site	Conserved Site
A, C	IPR019583	Disks large homolog 1-4, PDZ-associated domain	Domain
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C	IPR050614	Synaptic Scaffolding LAP/MAGUK Families	Family
A, C	IPR001452	SH3 domain	Domain
A, C	IPR004172	L27 domain	Domain
A, C	IPR036034	PDZ superfamily	Homologous Superfamily
A, C	IPR036892	L27 domain superfamily	Homologous Superfamily
B, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B, D	IPR000719	Protein kinase domain	Domain
B, D	IPR020590	Guanylate kinase, conserved site	Conserved Site
B, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D	IPR001452	SH3 domain	Domain
B, D	IPR008144	Guanylate kinase-like domain	Domain
B, D	IPR035473	CASK, SH3 domain	Domain
B, D	IPR008145	Guanylate kinase/L-type calcium channel beta subunit	Domain
B, D	IPR004172	L27 domain	Domain
B, D	IPR014775	L27 domain, C-terminal	Domain
B, D	IPR050716	Membrane-associated guanylate kinase	Family
B, D	IPR036034	PDZ superfamily	Homologous Superfamily
B, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D	IPR036892	L27 domain superfamily	Homologous Superfamily
B, D	IPR001478	PDZ domain	Domain