Annotations: 1TPB

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth 1]	d1tpb1_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Triosephosphate isomerase (TIM)	Triosephosphate isomerase (TIM)	Triosephosphate isomerase	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B [auth 2]	d1tpb2_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Triosephosphate isomerase (TIM)	Triosephosphate isomerase (TIM)	Triosephosphate isomerase	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth 1]	SCOP2B Superfamily	Triosephosphate isomerase (TIM)	8039744	3000190	SCOP2B (2022-06-29)
B [auth 2]	SCOP2B Superfamily	Triosephosphate isomerase (TIM)	8039744	3000190	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 1]	TIM	e1tpb11	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TIM	ECOD (1.6)
B [auth 2]	TIM	e1tpb21	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: TIM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth 1]	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)
B [auth 2]	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 1], B [auth 2]	PF00121	Triosephosphate isomerase (TIM)	Triosephosphate isomerase	Triosephosphate isomerase (EC:5.3.1.1) (TIM) [1] is the glycolytic enzyme that catalyses the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is ess ...	Triosephosphate isomerase (EC:5.3.1.1) (TIM) [1] is the glycolytic enzyme that catalyses the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism [2,3]. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure [4]. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1], B [auth 2]	TRIOSEPHOSPHATE ISOMERASE	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity triose-phosphate isomerase activity catalytic activity carbon-oxygen lyase activity, acting on phosphates lyase activity methylglyoxal synthase activity carbon-oxygen lyase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity triose-phosphate isomerase activity catalytic activity carbon-oxygen lyase activity, acting on phosphates lyase activity methylglyoxal synthase activity carbon-oxygen lyase activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	methylglyoxal biosynthetic process small molecule biosynthetic process ketone metabolic process aldehyde biosynthetic process aldehyde metabolic process biosynthetic process metabolic process cellular process small molecule metabolic process ketone biosynthetic process methylglyoxal metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process methylglyoxal biosynthetic process small molecule biosynthetic process ketone metabolic process aldehyde biosynthetic process aldehyde metabolic process biosynthetic process metabolic process cellular process small molecule metabolic process ketone biosynthetic process methylglyoxal metabolic process ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process nucleobase-containing compound metabolic process glycolytic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process monosaccharide metabolic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process glucose metabolic process polyol metabolic process alcohol catabolic process polyol catabolic process alcohol metabolic process alditol catabolic process glycerol metabolic process alditol metabolic process glycerol catabolic process small molecule catabolic process glucose catabolic process to pyruvate hexose catabolic process NADH metabolic process glucose catabolic process monosaccharide catabolic process canonical glycolysis glycolytic process through glucose-6-phosphate glycolytic process through fructose-6-phosphate carbohydrate derivative biosynthetic process glyceraldehyde-3-phosphate metabolic process organophosphate biosynthetic process glyceraldehyde-3-phosphate biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 1], B [auth 2]	IPR035990	Triosephosphate isomerase superfamily	Homologous Superfamily
A [auth 1], B [auth 2]	IPR000652	Triosephosphate isomerase	Family
A [auth 1], B [auth 2]	IPR020861	Triosephosphate isomerase, active site	Active Site
A [auth 1], B [auth 2]	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A [auth 1], B [auth 2]	IPR022896	Triosephosphate isomerase, bacterial/eukaryotic	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.