Annotations: 1UEA

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1uead_	All beta proteins	OB-fold	TIMP-like	Tissue inhibitor of metalloproteinases, TIMP	TIMP-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ueab_	All beta proteins	OB-fold	TIMP-like	Tissue inhibitor of metalloproteinases, TIMP	TIMP-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1ueac_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Matrix metalloproteases, catalytic domain	Stromelysin-1 (MMP-3)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ueaa_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Matrix metalloproteases, catalytic domain	Stromelysin-1 (MMP-3)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	TIMP-like	8042955	3000488	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	TIMP-like	8042955	3000488	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8035528	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8035528	3001975	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	TIMP	e1ueaD1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: TIMP	ECOD (1.6)
B	TIMP	e1ueaB1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: TIMP	ECOD (1.6)
C	Peptidase_M10	e1ueaC1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M10	ECOD (1.6)
A	Peptidase_M10	e1ueaA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.90.370.10	Alpha Beta	Alpha-Beta Complex	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	CATH (4.3.0)
D	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
B	3.90.370.10	Alpha Beta	Alpha-Beta Complex	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	CATH (4.3.0)
B	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
C	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
A	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF00965	Tissue inhibitor of metalloproteinase (TIMP)	Tissue inhibitor of metalloproteinase	Members of this family are common in extracellular regions of vertebrate species	Domain
A, C	PF00413	Matrixin (Peptidase_M10)	Matrixin	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, D	TISSUE INHIBITOR OF METALLOPROTEINASE-1	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme binding protease binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme binding protease binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity cytokine activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development response to stimulus response to hormone response to chemical response to endogenous stimulus developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development response to stimulus response to hormone response to chemical response to endogenous stimulus response to peptide hormone response to oxygen-containing compound response to nitrogen compound regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response defense response response to stress inflammatory response to wounding tissue remodeling connective tissue replacement inflammatory response response to wounding response to peptide response to cytokine regulation of molecular function regulation of catalytic activity negative regulation of molecular function negative regulation of catalytic activity cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process negative regulation of hydrolase activity negative regulation of proteolysis regulation of primary metabolic process negative regulation of peptidase activity regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of peptidase activity primary metabolic process regulation of macromolecule metabolic process regulation of metallopeptidase activity regulation of hydrolase activity negative regulation of metallopeptidase activity metabolic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cellular response to chemical stimulus cellular response to peptide negative regulation of endopeptidase activity regulation of endopeptidase activity multi-multicellular organism process negative regulation of locomotion regulation of cell motility regulation of trophoblast cell migration regulation of reproductive process reproductive process ameboidal-type cell migration regulation of cell migration cell migration regulation of multicellular organismal process cell motility female pregnancy embryo implantation negative regulation of trophoblast cell migration locomotion negative regulation of cell migration trophoblast cell migration negative regulation of reproductive process regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process multi-organism reproductive process negative regulation of membrane protein ectodomain proteolysis catabolic process macromolecule catabolic process negative regulation of protein catabolic process membrane protein proteolysis membrane protein ectodomain proteolysis negative regulation of catabolic process regulation of membrane protein ectodomain proteolysis protein catabolic process regulation of catabolic process regulation of protein catabolic process regulation of integrin-mediated signaling pathway regulation of signaling integrin-mediated signaling pathway cell surface receptor signaling pathway signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication signal transduction response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-A cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV response to UV-A	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen
A, C	MATRIX METALLOPROTEINASE-3	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity metalloendopeptidase activity endopeptidase activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity cation binding transition metal ion binding zinc ion binding ion binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity metalloendopeptidase activity endopeptidase activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	collagen catabolic process catabolic process metabolic process cellular process collagen metabolic process regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis biological regulation positive regulation of biological process regulation of cellular component biogenesis collagen catabolic process catabolic process metabolic process cellular process collagen metabolic process regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis biological regulation positive regulation of biological process regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process extracellular matrix organization extracellular structure organization external encapsulating structure organization regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress regulation of neuroinflammatory response inflammatory response neuroinflammatory response biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process cellular response to stimulus response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid response to molecule of bacterial origin cellular component disassembly extracellular matrix disassembly regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion response to nitrogen compound response to amyloid-beta negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process regulation of metabolic process regulation of reactive oxygen species metabolic process cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to stress cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-A cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV response to UV-A proteolysis cellular response to nitrogen compound cellular response to nitric oxide response to nitric oxide cellular response to reactive nitrogen species	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol cell periphery extracellular matrix external encapsulating structure extracellular region extracellular space membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol cell periphery extracellular matrix external encapsulating structure extracellular region extracellular space nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR001820	Protease inhibitor I35 (TIMP)	Family
B, D	IPR027465	Proteinase inhibitor I35b (TIMP), C-terminal	Homologous Superfamily
B, D	IPR001134	Netrin domain	Domain
B, D	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
B, D	IPR030490	Tissue inhibitor of metalloproteinase, conserved site	Conserved Site
A, C	IPR018486	Hemopexin, conserved site	Conserved Site
A, C	IPR036375	Hemopexin-like domain superfamily	Homologous Superfamily
A, C	IPR021158	Peptidase M10A, cysteine switch, zinc binding site	Binding Site
A, C	IPR036365	PGBD-like superfamily	Homologous Superfamily
A, C	IPR001818	Peptidase M10, metallopeptidase	Domain
A, C	IPR021190	Peptidase M10A	Family
A, C	IPR002477	Peptidoglycan binding-like	Domain
A, C	IPR006026	Peptidase, metallopeptidase	Domain
A, C	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A, C	IPR018487	Hemopexin-like repeats	Repeat
A, C	IPR000585	Hemopexin-like domain	Domain
A, C	IPR033739	Peptidase M10A, catalytic domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: P01033	aortic valve insufficiency Wilson disease oral submucous fibrosis IgA glomerulonephritis heart disease type 2 diabetes mellitus hypertensive disorder vascular disease adult acute respiratory distress syndrome Inflammation cholangitis extrahepatic cholestasis pulmonary fibrosis heart valve disease alcoholic liver cirrhosis aortic valve insufficiency Wilson disease oral submucous fibrosis IgA glomerulonephritis heart disease type 2 diabetes mellitus hypertensive disorder vascular disease adult acute respiratory distress syndrome Inflammation cholangitis extrahepatic cholestasis pulmonary fibrosis heart valve disease alcoholic liver cirrhosis autoimmune disease calcinosis varicose disease esophageal adenocarcinoma osteosarcoma pilocytic astrocytoma gastric carcinoma subependymal giant cell astrocytoma juvenile dermatomyositis Becker muscular dystrophy liver disease malignant colon neoplasm malignant mesothelioma medulloblastoma ductal breast carcinoma in situ ovarian cancer glioblastoma tuberculosis ulcerative colitis idiopathic interstitial pneumonia interstitial cystitis limb-girdle muscular dystrophy lung adenocarcinoma congestive heart failure malignant ependymoma diabetes mellitus malignant pancreatic neoplasm Emery-Dreifuss muscular dystrophy pancreatic ductal adenocarcinoma invasive ductal breast carcinoma Barrett esophagus cancer lung cancer Crohn disease malignant glioma maturity-onset diabetes of the young Duchenne muscular dystrophy myopathy
A, C	Pharos: P08254	protoplasmic astrocytoma subependymal giant cell astrocytoma gemistocytic astrocytoma idiopathic pulmonary fibrosis astrocytic tumor peripheral neuropathy coronary artery disease coronary restenosis anaplastic astrocytoma breast cancer Neoplasm Invasiveness childhood cerebral astrocytoma pilocytic astrocytoma fibrillary astrocytoma juvenile pilocytic astrocytoma protoplasmic astrocytoma subependymal giant cell astrocytoma gemistocytic astrocytoma idiopathic pulmonary fibrosis astrocytic tumor peripheral neuropathy coronary artery disease coronary restenosis anaplastic astrocytoma breast cancer Neoplasm Invasiveness childhood cerebral astrocytoma pilocytic astrocytoma fibrillary astrocytoma juvenile pilocytic astrocytoma breast carcinoma peripheral nervous system disease coronary heart disease, susceptibility to, 6 diffuse astrocytoma ulcerative colitis intracerebral hemorrhage malignant colon neoplasm bipolar disorder nasopharyngeal carcinoma breast fibroadenoma periodontitis psoriasis synovitis ductal breast carcinoma in situ interstitial cystitis astrocytoma (excluding glioblastoma) cancer peripheral arterial disease schizophrenia cystic fibrosis intervertebral disc degenerative disorder arthritic joint disease autoimmune disease non-small cell lung carcinoma cerebral astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.