1WXN | pdb_00001wxn

Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Defensin_4	e1wxnA1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: Defensin_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.20.20.10	Mainly Beta	Single Sheet	Anthopleurin-A	Anthopleurin-A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07936	Potassium-channel blocking toxin (Defensin_4)	Potassium-channel blocking toxin	This family features the antihypertensive and antiviral proteins BDS-I (Swiss:P11494) and BDS-II (Swiss:P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel be ...	This family features the antihypertensive and antiviral proteins BDS-I (Swiss:P11494) and BDS-II (Swiss:P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus [1]. Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure [2]. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Toxin APETx2	channel regulator activity ion channel inhibitor activity monoatomic ion channel activity ion channel regulator activity molecular function inhibitor activity passive transmembrane transporter activity transporter inhibitor activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity transporter regulator activity channel inhibitor activity transmembrane transporter activity channel regulator activity ion channel inhibitor activity monoatomic ion channel activity ion channel regulator activity molecular function inhibitor activity passive transmembrane transporter activity transporter inhibitor activity channel activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity transporter regulator activity channel inhibitor activity transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity potassium channel regulator activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity sodium channel activity sodium ion transmembrane transporter activity sodium channel regulator activity toxin activity	-	cellular anatomical structure extracellular region cell periphery intracellular organelle cell cortex intracellular anatomical structure organelle membraneless organelle nematocyst intracellular membraneless organelle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012414	BDS potassium channel toxin	Family
A	IPR023355	Myotoxin/Anemone neurotoxin domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.