Annotations: 1YGO

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ygoa2	All alpha proteins	DEATH domain	DEATH domain	DEATH domain, DD	Pelle death domain	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d1ygoa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DEATH domain	8037993	3000069	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Death	e1ygoA1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00531	Death domain (Death)	Death domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Probable serine/threonine-protein kinase pelle	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity histone H2B kinase activity histone H3S57 kinase activity protein binding protein domain specific binding Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular process cellular response to cytokine stimulus signal transduction regulation of humoral immune response regulation of immune effector process positive regulation of response to biotic stimulus antifungal peptide production positive regulation of macromolecule biosynthetic process response to biotic stimulus positive regulation of metabolic process antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of immune response antifungal humoral response regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of immune system process response to other organism immune response response to external stimulus positive regulation of antifungal peptide production immune effector process regulation of gene expression regulation of defense response to fungus biosynthetic process regulation of response to stimulus defense response to other organism positive regulation of defense response positive regulation of production of molecular mediator of immune response regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response regulation of metabolic process regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of biological process antimicrobial humoral response positive regulation of response to stimulus positive regulation of antimicrobial peptide production positive regulation of humoral immune response positive regulation of response to external stimulus positive regulation of biosynthetic process antimicrobial peptide production response to stress regulation of response to stress positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process regulation of antimicrobial humoral response defense response defense response to symbiont regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of antifungal peptide production defense response to fungus positive regulation of antimicrobial humoral response regulation of antimicrobial peptide production positive regulation of gene expression immune system process response to fungus cell population proliferation hemocyte proliferation developmental process dorsal/ventral pattern formation multicellular organism development multicellular organismal process anatomical structure development pattern specification process regionalization embryonic pattern specification dorsal/ventral axis specification embryo development embryonic axis specification zygotic specification of dorsal/ventral axis axis specification apoptotic process cell death programmed cell death innate immune response Toll signaling pathway muscle structure development somatic muscle development larval somatic muscle development larval development post-embryonic development antifungal innate immune response determination of bilateral symmetry determination of dorsal/ventral asymmetry specification of symmetry catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis protein metabolic process regulation of protein metabolic process primary metabolic process protein catabolic process regulation of catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process modification-dependent protein catabolic process positive regulation of proteolysis ubiquitin-dependent protein catabolic process response to lipid cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to lipid response to molecule of bacterial origin positive regulation of protein catabolic process regulation of protein catabolic process hippo signaling positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of hippo signaling regulation of cell communication regulation of hippo signaling positive regulation of signaling	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000719	Protein kinase domain	Domain
A	IPR052059	Cysteine-rich Ser/Thr receptor-like kinase	Family
A	IPR000488	Death domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR037924	Pelle, death domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.