Annotations: 1Z6C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EGF_CA	e1z6cA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF_CA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07645	Calcium-binding EGF domain (EGF_CA)	Calcium-binding EGF domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Vitamin K-dependent protein S	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of response to external stimulus negative regulation of biological process regulation of response to wounding multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding regulation of response to external stimulus negative regulation of biological process regulation of response to wounding regulation of coagulation regulation of response to stress regulation of multicellular organismal process regulation of hemostasis regulation of biological process negative regulation of response to stimulus negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation response to external stimulus negative regulation of response to wounding negative regulation of hemostasis fibrinolysis negative regulation of coagulation regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication cellular process phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane intracellular anatomical structure extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane Golgi apparatus membrane-enclosed lumen intracellular organelle lumen Golgi lumen organelle lumen blood microparticle Golgi membrane bounding membrane of organelle vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain	Domain
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR013032	EGF-like, conserved site	Conserved Site
A	IPR000742	EGF-like domain	Domain
A	IPR001791	Laminin G domain	Domain
A	IPR049883	NOTCH1 EGF-like calcium-binding domain	Domain
A	IPR051145	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent	Family
A	IPR017857	Coagulation factor-like, Gla domain superfamily	Homologous Superfamily
A	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Homologous Superfamily
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P07225	thrombophilia due to protein S deficiency, autosomal dominant sagittal sinus thrombosis thrombophilia due to protein S deficiency, autosomal recessive Thromboembolism adult acute respiratory distress syndrome thrombophilia juvenile idiopathic arthritis protein S deficiency thrombophilia due to activated protein C resistance vitamin K deficiency hemorrhagic disease lung cancer malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor thrombophilia due to protein S deficiency, autosomal dominant sagittal sinus thrombosis thrombophilia due to protein S deficiency, autosomal recessive Thromboembolism adult acute respiratory distress syndrome thrombophilia juvenile idiopathic arthritis protein S deficiency thrombophilia due to activated protein C resistance vitamin K deficiency hemorrhagic disease lung cancer malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor sinusitis colorectal cancer Duchenne muscular dystrophy gastric carcinoma IgA glomerulonephritis lung carcinoma malignant pancreatic neoplasm oligodendroglioma pilocytic astrocytoma breast cancer spondyloarthropathy cystic fibrosis exocrine pancreatic carcinoma glioblastoma interstitial cystitis tuberculosis lung adenocarcinoma malignant ependymoma MALT lymphoma ovarian cancer astrocytic tumor breast carcinoma subependymal giant cell astrocytoma dermatomyositis gastric cancer hereditary thrombophilia due to congenital protein S deficiency invasive ductal breast carcinoma thrombotic disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.